{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:16:31Z","timestamp":1769163391304,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007132","name":"Otsuka Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.euroneuro.2018.12.012","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T17:09:39Z","timestamp":1546535379000},"page":"376-383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-3743","authenticated-orcid":false,"given":"E. Sherwood","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasreen","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Tustison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Yassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Van Enkevort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyson","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena I.","family":"Ivleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabha","family":"Sunderajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"McEwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kulikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Frol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Traci","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2018.12.012_bib0001","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0002","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.neuroimage.2009.09.062","article-title":"The optimal template effect in hippocampus studies of diseased populations","volume":"49","author":"Avants","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0003","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/00004583-198811000-00010","article-title":"Mood and memory changes in asthmatic children receiving corticosteroids","volume":"27","author":"Bender","year":"1988","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0004","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/archpsyc.60.4.392","article-title":"A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder","volume":"60","author":"Bowden","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nlm.2005.12.009","article-title":"Effect of two prednisone exposures on mood and declarative memory","volume":"86","author":"Brown","year":"2006","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0006","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1176\/appi.psy.44.3.204","article-title":"Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids","volume":"44","author":"Brown","year":"2003","journal-title":"Psychosomatics"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0007","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/npp.2014.307","article-title":"Hippocampal volume in healthy controls given 3-day stress doses of hydrocortisone","volume":"40","author":"Brown","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0008","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jad.2013.01.038","article-title":"A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes","volume":"150","author":"Brown","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0009","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/sj.npp.1301627","article-title":"Attenuation of the effects of corticosteroids on declarative memory with lamotrigine","volume":"33","author":"Brown","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0010","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.biopsych.2003.09.010","article-title":"Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy","volume":"55","author":"Brown","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0011","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nm.2682","article-title":"2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas","volume":"18","author":"Choi","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0012","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1523\/JNEUROSCI.4893-07.2008","article-title":"Glucocorticoid therapy-induced memory deficits: acute versus chronic effects","volume":"28","author":"Coluccia","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0013","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s11064-012-0942-7","article-title":"Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the hippocampus of PTZ-kindled epileptic and PTZ-induced status epilepticus rats","volume":"38","author":"Deng","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0014","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.psyneuen.2014.03.003","article-title":"Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure","volume":"44","author":"Ewald","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0015","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/mrm.1910290613","article-title":"Automatic, localized in vivo adjustment of all first- and second-order shim coils","volume":"29","author":"Gruetter","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0016","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1136\/ard.2007.072157","article-title":"EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases","volume":"66","author":"Hoes","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0017","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.nicl.2018.04.012","article-title":"Hippocampal metabolites in asthma and their implications for cognitive function","volume":"19","author":"Kroll","year":"2018","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0018","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1523\/JNEUROSCI.16-10-03534.1996","article-title":"Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews","volume":"16","author":"Magarinos","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0019","doi-asserted-by":"crossref","first-page":"14002","DOI":"10.1073\/pnas.94.25.14002","article-title":"Chronic stress alters synaptic terminal structure in hippocampus","volume":"94","author":"Magarinos","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1258\/ebm.2009.009225","article-title":"Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays","volume":"235","author":"Mariotti","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0021","series-title":"Designing Experiments and Analyzing data: A model Comparison Perspective","author":"Maxwell","year":"2004"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0022","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2015.12.043","article-title":"Stress-induced remodeling of hippocampal CA3 pyramidal neurons","volume":"1645","author":"McEwen","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0023","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/bdi.12262","article-title":"Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons","volume":"17","author":"Park","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0024","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0025","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0026","series-title":"Hierarchical Linear models: Applications and Data Analysis Methods","author":"Raudenbush","year":"2002"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0027","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1210\/jc.2011-2231","article-title":"Verbal and visual memory performance and hippocampal volumes, measured by 3-Tesla magnetic resonance imaging, in patients with Cushing's syndrome","volume":"97","author":"Resmini","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0028","series-title":"Rey Auditory Verbal Learning Test: A Handbook","author":"Schmidt","year":"1996"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0029","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.neuropharm.2006.09.002","article-title":"Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings","volume":"52","author":"Sitges","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/mp.2014.54","article-title":"Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia","volume":"20","author":"Stan","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0031","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0006-3223(92)90079-F","article-title":"Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome","volume":"32","author":"Starkman","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0032","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fninf.2013.00039","article-title":"Explicit B-spline regularization in diffeomorphic image registration","volume":"7","author":"Tustison","year":"2013","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0033","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1523\/JNEUROSCI.22-15-06810.2002","article-title":"Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons","volume":"22","author":"Vyas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0034","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1109\/TPAMI.2012.143","article-title":"Multi-atlas segmentation with joint label fusion","volume":"35","author":"Wang","year":"2013","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0035","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1097\/00001756-200107200-00042","article-title":"Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity","volume":"12","author":"Wang","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0036","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1073\/pnas.1101567108","article-title":"Age-related memory deficits linked to circuit-specific disruptions in the hippocampus","volume":"108","author":"Yassa","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.euroneuro.2018.12.012_bib0037","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X18320029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X18320029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:43:51Z","timestamp":1565225031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X18320029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0924977X18320029"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2018.12.012","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2018.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}