{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:23:20Z","timestamp":1785363800586,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"am","delay-in-days":306,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["HHSN271201100006I"],"award-info":[{"award-number":["HHSN271201100006I"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.euroneuro.2021.04.024","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T02:09:48Z","timestamp":1622686188000},"page":"122-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["The effect of single administration of intravenous ketamine augmentation on suicidal ideation in treatment-resistant unipolar depression: Results from a randomized double-blind study"],"prefix":"10.1016","volume":"49","author":[{"given":"Anna","family":"Feeney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Hock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene.P.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Hoeppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan V.","family":"Iosifescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhukar H.","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Sanacora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay J.","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Debattista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn F.","family":"Ionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George I.","family":"Papakostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2021.04.024_bib0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jpsychires.2014.07.027","article-title":"Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety","volume":"58","author":"Ballard","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0002","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neubiorev.2017.03.010","article-title":"Ketamine as a rapid-acting agent for suicidal ideation: a meta-analysis","volume":"77","author":"Bartoli","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0003","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-0447.1981.tb00676.x","article-title":"The Hamilton Depression Scale: evaluation of objectivity using logistic models","volume":"63","author":"Bech","year":"1981","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0004","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/da.22505","article-title":"Ketamine for treatment-resistant unipolar and bipolar major depression: critical review and implications for clinical practice","volume":"33","author":"Bobo","year":"2016","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0005","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.7205\/MILMED-D-15-00431","article-title":"A double-blinded, randomized, placebo-controlled sub-dissociative dose ketamine pilot study in the treatment of acute depression and suicidality in a military emergency department setting","volume":"181","author":"Burger","year":"2016","journal-title":"Mil. Med."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0006","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1176\/appi.ajp.2018.17060720","article-title":"Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: results of a Double-Blind, Randomized, Placebo-Controlled Study","volume":"175","author":"Canuso","year":"2018","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0007","doi-asserted-by":"crossref","first-page":"p133","DOI":"10.1159\/000506879","article-title":"The hamilton rating scales for depression: a critical review of clinimetric properties of different versions","volume":"89","author":"Carrozzino","year":"2020","journal-title":"Psychother. Psychosom"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0008","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1755-5949.2009.00102.x","article-title":"Validation of the massachusetts general hospital Antidepressant Treatment History Questionnaire (ATRQ)","volume":"16","author":"Chandler","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0009","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.3390\/ijms19102888","article-title":"Eradicating suicide at its roots: preclinical bases and clinical evidence of the efficacy of ketamine in the treatment of suicidal behaviors","volume":"19","author":"De Berardis","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0010","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/da.22975","article-title":"Ketamine for acute suicidal ideation. An emergency department intervention: a randomized, double-blind, placebo-controlled, proof-of-concept trial","volume":"37","author":"Domany","year":"2020","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0011","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41380-018-0256-5","article-title":"Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)","volume":"25","author":"Fava","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0012","unstructured":"FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor's office or clinic | FDA, URL https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-nasal-spray-medication-treatment-resistant-depression-available-only-certified (accessed 05.02.2021)."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0013","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.19m13191","article-title":"Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent","volume":"81","author":"Fu","year":"2020","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0014","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1176\/appi.ajp.2017.17060647","article-title":"Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial","volume":"175","author":"Grunebaum","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiat"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0016","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jad.2018.09.037","article-title":"Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: a randomized, double blind, placebo controlled trial","volume":"243","author":"Ionescu","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0017","article-title":"Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients with Major Depressive Disorder Who Have Active Suicide Ideation with Intent: results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II)","author":"Ionescu","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0018","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_sbref0019","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41386-019-0570-x","article-title":"Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression","volume":"45","author":"Phillips","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/da.22253","article-title":"Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression","volume":"31","author":"Price","year":"2014","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0021","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.biopsych.2009.04.029","article-title":"Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression","volume":"66","author":"Price","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0022","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jad.2019.09.017","article-title":"Time to relapse after a single administration of intravenous ketamine augmentation in unipolar treatment-resistant depression","volume":"260","author":"Salloum","year":"2019","journal-title":"J Affect Disord"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0023","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1001\/jamapsychiatry.2017.0080","article-title":"A consensus statement on the use of ketamine in the treatment of mood disorders","volume":"74","author":"Sanacora","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0024","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/eb-2016-102355","article-title":"Ketamine for treatment-resistant depression: recent developments and clinical applications","volume":"19","author":"Schwartz","year":"2016","journal-title":"Evid. Based. Ment. Health"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0025","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/1570159X12666140619204251","article-title":"The role of ketamine in treatment-resistant depression: a systematic review","volume":"12","author":"Serafini","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172732","article-title":"Off-label uses of drugs for depression","volume":"865","author":"Sk\u00e5nland","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0027","unstructured":"SPRAVATO \u00ae (esketamine) nasal spray, CIII highlights of prescribing information, 2020, URL https:\/\/www.janssenlabels.com\/package-insert\/product-monograph\/prescribing-information\/SPRAVATO-pi.pdf (accessed 05.02.2021)"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0028","doi-asserted-by":"crossref","unstructured":"Wilkinson, S.T., Ballard, E.D., Bloch, M.H., Mathew, S.J., Murrough, J.W., Feder, A., Sos, P., Wang, G., Zarate, C.A., Sanacora, G., 2018. The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis, in: american Journal of Psychiatry. American Psychiatric Association, pp. 150\u2013158.","DOI":"10.1176\/appi.ajp.2017.17040472"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0029","first-page":"29","article-title":"Ketamine for suicidal ideation in adults with psychiatric disorders: a systematic review and meta-analysis of treatment trials 883341A NP ANZJP ArticlesWitt et\u00a0al. ANZJP Artic. Aust. New Zeal","volume":"54","author":"Witt","year":"2020","journal-title":"J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2021.04.024_bib0030","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/0269881119827811","article-title":"Investigation of medical effect of multiple ketamine infusions on patients with major depressive disorder","volume":"33","author":"Zheng","year":"2019","journal-title":"J. Psychopharmacol."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X21002200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X21002200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:01:13Z","timestamp":1760378473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X21002200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":30,"alternative-id":["S0924977X21002200"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2021.04.024","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of single administration of intravenous ketamine augmentation on suicidal ideation in treatment-resistant unipolar depression: Results from a randomized double-blind study","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2021.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. and ECNP. All rights reserved.","name":"copyright","label":"Copyright"}]}}