{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:16:35Z","timestamp":1770473795657,"version":"3.49.0"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"unspecified","delay-in-days":5829,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2004,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To study the types of psychiatric problem encountered in children infected with the human immunodeficiency virus (HIV) and their relationship to central nervous system disorder and the severity of infection.<\/jats:p><\/jats:sec>Methods<\/jats:title>17 HIV-infected children presenting with psychiatric problems were included. Mental disorders were evaluated according to DSM-IV criteria. Neurological disorders and progressive encephalopathy (presence or absence) diagnosis were evaluated by clinical and radiological examination. The severity of infection was assessed by the percentage of CD4 lymphocytes.<\/jats:p><\/jats:sec>Results<\/jats:title>The most frequent diagnoses were major depression (MDD: 47%) and attention deficit hyperactivity disorder (ADHD: 29%). Major depression diagnosis was significantly associated with neuroimaging or clinical neurological abnormalities (p < 0.01). In contrast, no association was found between hyperactivity diagnosed according to DSM-IV criteria and central nervous system disorder. Percentage of CD4 lymphocytes were close to 0 for more than 80% of children presenting with psychiatric complications.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The very low % of CD4 lymphocytes of these children suggest that the appearance of a psychiatric complication should be regarded as a factor indicating severe HIV infection. Depressive disorders may be a clinical form of encephalopathy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2003.06.009","type":"journal-article","created":{"date-parts":[[2004,4,23]],"date-time":"2004-04-23T09:53:24Z","timestamp":1082714004000},"page":"182-184","source":"Crossref","is-referenced-by-count":40,"title":["DSM-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type 1 infection (HIV-1)"],"prefix":"10.1017","volume":"19","author":[{"given":"D.","family":"Misdrahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Funk-Brentano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tardieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Blanche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Mouren-Simeoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"S0924933800010257_ref8","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/archpedi.1997.02170470059011","article-title":"Spontaneous eye blinking, a measure of dopaminergic function, in children with acquired immunodeficiency syndrome","volume":"151","author":"Vreugdenhil","year":"1997","journal-title":"Arch Pediatr Adolesc Med"},{"key":"S0924933800010257_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199802000-00003"},{"key":"S0924933800010257_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199406001-00005"},{"key":"S0924933800010257_ref4","unstructured":"[4] Classification system for human immunodeficiency virus (HIV) infection in children under 13 years of age. MMWR Morb Mortal Wkly Rep 1987; 36: 225\u201336."},{"key":"S0924933800010257_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199305000-00011"},{"key":"S0924933800010257_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250043011"},{"key":"S0924933800010257_ref1","volume-title":"Diagnostic and statistical manual of mental disorders DSM IV","year":"1995"},{"key":"S0924933800010257_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/19.1.27"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933804000318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933804000318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933800010257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T08:06:13Z","timestamp":1601539573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933800010257\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0924933800010257"],"URL":"https:\/\/doi.org\/10.1016\/j.eurpsy.2003.06.009","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}