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Given the attentional disturbances associated with this syndrome, and the improvements in attentional processes reported with nicotine, this randomized, double-blind, placebo-controlled trial examined the acute (4 h) and sustained (2 weeks) effects of a single dose of transdermal nicotine on clinical (i.e., tics), attentional (continuous performance task, event-related potentials, patient and parental reports) and behavioral symptoms in 23 children and adolescents with TS receiving neuroleptic treatment. In the 14 evaluable patients with complete primary efficacy data, nicotine (compared to placebo) failed to alter symptoms at 4 h but counteracted ERP-P300 signs of diminished attention seen 2 weeks following placebo treatment. Secondary efficacy measures, including patient self-reports and parental ratings, found nicotine to reduce complex tics and improve behaviors related to inattention. Additional work with intermittent dosing schedules is required to characterize optimal clinical and cognitive effects with nicotine treatment.<\/jats:p>","DOI":"10.1016\/j.eurpsy.2003.11.002","type":"journal-article","created":{"date-parts":[[2004,3,12]],"date-time":"2004-03-12T10:20:08Z","timestamp":1079086808000},"page":"102-112","source":"Crossref","is-referenced-by-count":50,"title":["Clinical and attentional effects of acute nicotine treatment in Tourette\u2019s syndrome"],"prefix":"10.1017","volume":"19","author":[{"given":"Anne L.","family":"Howson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Batth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim","family":"Ilivitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Boisjoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Jaworski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verner J.","family":"Knott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"S0924933800009524_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00545-5"},{"key":"S0924933800009524_ref49","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.9.2.157"},{"key":"S0924933800009524_ref48","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0908"},{"key":"S0924933800009524_ref46","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7445-8_38"},{"key":"S0924933800009524_ref43","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.958"},{"key":"S0924933800009524_ref42","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.11.1.147"},{"key":"S0924933800009524_ref41","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(197210)28:4<596::AID-JCLP2270280445>3.0.CO;2-Z"},{"key":"S0924933800009524_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/0753-3322(89)90186-8"},{"key":"S0924933800009524_ref36","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540070045013"},{"key":"S0924933800009524_ref35","first-page":"21","volume-title":"Nicotine, caffeine and social drinking: behavior and brain function","author":"Pritchard","year":"1998"},{"key":"S0924933800009524_ref33","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836276"},{"key":"S0924933800009524_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90444-X"},{"key":"S0924933800009524_ref30","first-page":"359","volume-title":"Marijuana: an international research report, Monograph Series No 7.","author":"Moss","year":"1988"},{"key":"S0924933800009524_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90315-Q"},{"key":"S0924933800009524_ref28","first-page":"793","article-title":"Nicotine potentiation of haloperidol in reducing tic frequency in Tourette\u2019s disorder.","volume":"148","author":"McConville","year":"1991","journal-title":"Am J Psychiatry"},{"key":"S0924933800009524_ref26","first-page":"429","volume-title":"Neuropsy-chopharmacol","volume":"15","author":"Levin","year":"1996"},{"key":"S0924933800009524_ref23","first-page":"6","volume-title":"editors. 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