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Early experimental work suggests that alcoholic subjects, compared to non-alcoholics, are less sensitive to sodium lactate and that alcohol intake reduces the response to a 35% CO<jats:sub>2<\/jats:sub>challenge in Panic Disorder patients. The present study documents the direct pharmacological effect of ethanol infusion on CO<jats:sub>2<\/jats:sub>induced panic.<\/jats:p><jats:sec id=\"S0924933800067237_abs1\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>According to a placebo-controlled, double-blind, randomized, cross-over design 10 drug free panic disorder patients and 16 healthy volunteers underwent a 35% CO<jats:sub>2<\/jats:sub>challenge after intravenous infusion of a moderate dose of ethanol on one test day and of placebo on another test day.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800067237_abs2\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Compared to the placebo condition, the effect of the CO<jats:sub>2<\/jats:sub>challenge was significantly smaller after ethanol infusion (<jats:italic>P<\/jats:italic>= 0.041).<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800067237_abs3\" sec-type=\"discussion\"><jats:title>Discussion<\/jats:title><jats:p>A moderate dose of ethanol decreased the response to a 35% CO<jats:sub>2<\/jats:sub>without inducing pre challenge sedation.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800067237_abs4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>The results comfort earlier findings of a direct pharmacological effect of ethanol on panic.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2004.06.009","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T18:37:14Z","timestamp":1096396634000},"page":"299-303","source":"Crossref","is-referenced-by-count":11,"title":["The influence of ethanol infusion on the effects of 35% CO<sub>2<\/sub>challenge. 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