{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:00:41Z","timestamp":1761764441243},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"unspecified","delay-in-days":5433,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800066839_abs1\" sec-type=\"other\"><jats:title>Background<\/jats:title><jats:p>Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia the patients suffering from other psychiatric disorders and the general healthy population. The objective of the current study was to determine whether patients with schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome, GS) have specific changes in signal intensities on fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) images.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800066839_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Axial 5-mm-thick FLAIR MR images from schizophrenia patients with GS (<jats:italic>n<\/jats:italic> = 18) and schizophrenia patients without GS (<jats:italic>n<\/jats:italic> = 18), all diagnosed according to DSM-IV criteria, were compared with age- and sex-matched non-psychiatric controls (<jats:italic>n<\/jats:italic> = 18). Signal intensities in the hippocampus, amygdala, caudate, putamen, thalamus, cingulate gyrus, and insula were graded relative to cortical signal intensity in the frontal lobe.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800066839_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Compared to both schizophrenia patients without GS and normal controls, the schizophrenia patients with GS showed significantly increased signal intensities in almost all regions studied.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800066839_abs4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Patients with schizophrenia-associated GS have specific changes of signal intensities on FLAIR MR images, suggesting that schizophrenia with GS produces changes in the fronto-temporal cortex, limbic system, and basal ganglia.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2004.12.012","type":"journal-article","created":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T13:19:02Z","timestamp":1112966342000},"page":"327-331","source":"Crossref","is-referenced-by-count":14,"title":["Fluid-attenuated inversion-recovery MR imaging in schizophrenia-associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's 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