{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:19:35Z","timestamp":1759339175658},"reference-count":60,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"unspecified","delay-in-days":5219,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Second generation antipsychotic agents are increasingly used in the management of acute mania. A systematic review of the efficacy and safety of these agents, as both monotherapy and in combination with mood stabilisers, was performed to establish the evidence for their use. Randomised controlled trials (RCTs) were critically appraised in more detail than studies that presented lower levels of evidence such as case reports, case series and open label follow up studies. We found 11 RCTs reporting on patients treated with second generation antipsychotics for acute bipolar mania, of which three included randomisation between the second generation antipsychotic and placebo, and eight between a mood stabiliser combined with either the second generation antipsychotic or placebo. Data from non-randomised trials is also presented.<\/jats:p>","DOI":"10.1016\/j.eurpsy.2005.02.002","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T11:28:51Z","timestamp":1113996531000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["A systematic review of the efficacy and safety of second generation antipsychotics in the treatment of mania"],"prefix":"10.1017","volume":"21","author":[{"given":"R.M.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"S0924933800239734_bib56","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00481-5"},{"key":"S0924933800239734_bib11","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.41.s148"},{"key":"S0924933800239734_bib59","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.2.141"},{"key":"S0924933800239734_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00004714-199702000-00013","article-title":"Induction of mania by risperidone resistant to mood stabilizers","volume":"17","author":"Barkin","year":"1997","journal-title":"J. Clin. Psychopharmacol."},{"key":"S0924933800239734_bib28","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1062-x"},{"key":"S0924933800239734_bib23","first-page":"431","article-title":"Risperidone treatment of refractory acute mania","volume":"56","author":"Goodnick","year":"1995","journal-title":"J. Clin. Psychiatry"},{"key":"S0924933800239734_bib31","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199802000-00002"},{"key":"S0924933800239734_bib46","first-page":"40","article-title":"Treatment of bipolar mixed state with olanzapine","volume":"24","author":"Sharma","year":"1999","journal-title":"J. Psychiatry Neurosci."},{"key":"S0924933800239734_bib44","first-page":"55","article-title":"Risperidone therapy in treatment refractory acute bipolar and schizoaffective mania","volume":"32","author":"Sajatovic","year":"1996","journal-title":"Psychopharmacol. Bull."},{"key":"S0924933800239734_bib41","first-page":"309","article-title":"Mania-like syndrome in a patient with chronic schizophrenia during olanzapine treatment","volume":"23","author":"Pozo","year":"1998","journal-title":"J. Psychiatry Neurosci."},{"key":"S0924933800239734_bib39","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00310-X"},{"key":"S0924933800239734_bib1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0910"},{"key":"S0924933800239734_bib37","first-page":"349","volume":"29","author":"Monreal","year":"2001","journal-title":"Actas Esp. Psiquiatr."},{"key":"S0924933800239734_bib50","volume-title":"Schedule for affective disorders and schizophrenia: change version","author":"Spitzer","year":"1978"},{"key":"S0924933800239734_bib51","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1176\/ajp.156.8.1164","article-title":"Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania","volume":"156","author":"Suppes","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"S0924933800239734_bib30","first-page":"S3","article-title":"The usefulness and use of second-generation antipsychotic medications. Review of evidence and recommendations by a Task Force of the World Psychiatric Association","volume":"15","author":"Kupfer","journal-title":"Curr Opin Psychiatry"},{"key":"S0924933800239734_bib10","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200006000-00013"},{"key":"S0924933800239734_bib26","first-page":"200","article-title":"Olanzapine-induced mania in bipolar disorders","volume":"27","author":"Henry","year":"2002","journal-title":"J. Psychiatry Neurosci."},{"key":"S0924933800239734_bib25","unstructured":"[25] Guezelcan, Y Risperidone may induce mania. Psychopharmacology (Berl.) 2000;:162 (June)."},{"key":"S0924933800239734_bib38","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0317a"},{"key":"S0924933800239734_bib21","doi-asserted-by":"publisher","DOI":"10.1177\/070674379704200211"},{"key":"S0924933800239734_bib27","first-page":"1054","article-title":"Aggression, agitation, and mania with olanzapine","volume":"43","author":"John","year":"1998","journal-title":"Can. J. Psychiatry"},{"key":"S0924933800239734_bib5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1979.tb04484.x"},{"key":"S0924933800239734_bib45","first-page":"176","article-title":"Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial","volume":"21","author":"Segal","year":"1998","journal-title":"Clin. Neuropharmacol."},{"key":"S0924933800239734_bib33","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(00)00132-2"},{"key":"S0924933800239734_bib34","doi-asserted-by":"publisher","DOI":"10.1089\/104454602760219135"},{"key":"S0924933800239734_bib36","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00002-0"},{"key":"S0924933800239734_bib15","first-page":"143","article-title":"The efficacy of olanzapine monotherapy for acute hypomania or mania in an outpatient setting","volume":"18","author":"Dennehy","year":"2003","journal-title":"Int. Clin. Psychopharmacol."},{"key":"S0924933800239734_bib7","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199911000-00003"},{"key":"S0924933800239734_bib18","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199908000-00011"},{"key":"S0924933800239734_bib43","first-page":"1","article-title":"The Expert Consensus Guideline Series: medication treatment of bipolar disorder 2000","author":"Sachs","year":"2002","journal-title":"Postgrad. Med."},{"key":"S0924933800239734_bib3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2003.02258.x"},{"key":"S0924933800239734_bib24","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.6.982"},{"key":"S0924933800239734_bib35","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200108000-00006"},{"key":"S0924933800239734_bib19","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(97)00160-2"},{"key":"S0924933800239734_bib13","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200210000-00011"},{"key":"S0924933800239734_bib20","doi-asserted-by":"publisher","DOI":"10.3109\/10401239909147062"},{"key":"S0924933800239734_bib22","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00313-X"},{"key":"S0924933800239734_bib52","first-page":"249","article-title":"Risperidone in the treatment of mania","volume":"57","author":"Tohen","year":"1996","journal-title":"J. Clin. Psychiatry"},{"key":"S0924933800239734_bib54","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.9.841"},{"key":"S0924933800239734_bib58","doi-asserted-by":"publisher","DOI":"10.3109\/10401239709147807"},{"key":"S0924933800239734_bib16","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.8.1341"},{"key":"S0924933800239734_bib6","first-page":"607","article-title":"Olanzapine-induced psychotic mania in bipolar schizoaffective disorder","volume":"44","author":"Benazzi","year":"1999","journal-title":"Can. J. Psychiatry"},{"key":"S0924933800239734_bib48","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1176\/ajp.153.9.1235","article-title":"Manic symptoms associated with initiation of risperidone","volume":"153","author":"Schnierow","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"S0924933800239734_bib40","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.1"},{"key":"S0924933800239734_bib29","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.4.741"},{"key":"S0924933800239734_bib9","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2000.10.45"},{"key":"S0924933800239734_bib49","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00119-0"},{"key":"S0924933800239734_bib8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1176\/ajp.153.6.759","article-title":"Clozapine for treatment-refractory mania","volume":"153","author":"Calabrese","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"S0924933800239734_bib12","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.4.673"},{"key":"S0924933800239734_bib55","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1176\/ajp.156.5.702","article-title":"Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group","volume":"156","author":"Tohen","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"S0924933800239734_bib32","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1214j"},{"key":"S0924933800239734_bib53","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.1.62"},{"key":"S0924933800239734_bib14","first-page":"41","article-title":"Mania associated with risperidone use","volume":"57","author":"Diaz","year":"1996","journal-title":"J. Clin. Psychiatry"},{"key":"S0924933800239734_bib57","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.01204.x"},{"key":"S0924933800239734_bib60","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"S0924933800239734_bib2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00335-X"},{"key":"S0924933800239734_bib42","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.7.1146"},{"key":"S0924933800239734_bib17","doi-asserted-by":"publisher","DOI":"10.1089\/10445460152595568"},{"key":"S0924933800239734_bib47","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200209000-00003"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933805000477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933805000477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933800239734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:53:55Z","timestamp":1683075235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933800239734\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0924933800239734"],"URL":"https:\/\/doi.org\/10.1016\/j.eurpsy.2005.02.002","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}