{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:35:43Z","timestamp":1790386543181,"version":"4.1.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"unspecified","delay-in-days":3485,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800067742_abs1\" sec-type=\"other\"><jats:title>Objectives<\/jats:title><jats:p>To explore factors associated with work impairment at 2 years following an acute episode.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800067742_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>European Mania in Bipolar disorder Longitudinal Evaluation of Medication (EMBLEM) is a prospective, observational study on the outcomes of patients with a manic\/mixed episode. Work impairment was measured using a Longitudinal Interval Follow-up Evaluation (slice of LIFE) item and patients were categorised with either low or high work impairment at each observation. Baseline factors associated with work impairment at 2 years were assessed using multivariate modelling.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800067742_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>At baseline (<jats:italic>n<\/jats:italic> = 2289), 69% of patients had high work impairment. At 2 years (<jats:italic>n<\/jats:italic> = 1393), high impairment reduced to 41%. Modelling identified rapid cycling as the strongest disease-related factor associated with high work impairment at 2 years, although high work impairment at baseline had the strongest association overall. Lower levels of education, recent admissions, CGI-BP overall severity in the 12 months prior to baseline and CGI-BP mania at baseline all predicted higher work impairment. Living together in a relationship and independent housing were both significantly associated with having low work impairment at 2 years.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800067742_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Work impairment in bipolar disorder is maintained over long periods, and is strongly associated with relationship status, living conditions and various disease-related factors.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2010.01.001","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T06:28:19Z","timestamp":1272868099000},"page":"338-344","source":"Crossref","is-referenced-by-count":30,"title":["Work impairment in bipolar disorder patients \u2013 results from a two-year observational study (EMBLEM)"],"prefix":"10.1017","volume":"25","author":[{"given":"C.","family":"Reed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EMBLEM Advisory Board","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"S0924933800067742_bib27","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00123-6"},{"key":"S0924933800067742_bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.06.011"},{"key":"S0924933800067742_bib3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1176\/ajp.150.5.720","article-title":"The enduring psychosocial consequences of mania and depression","volume":"150","author":"Coryell","year":"1993","journal-title":"Am J Psychiatry"},{"key":"S0924933800067742_bib28","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/18.2.273"},{"key":"S0924933800067742_bib20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00327.x"},{"key":"S0924933800067742_bib33","first-page":"301","article-title":"A user-friendly scale for the short and long term outcome of bipolar disorder: the CGI-BP-M. 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