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The following independent variables were associated with FE mania: a shorter delay before correct diagnosis, greater substance use, being not divorced, greater stressors before current mania, a prior diagnosis of an anxiety disorder, lower levels of depression during index manic episode, and more suicide attempts in the past year.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800259257_abs4\" sec-type=\"conclusions\"><jats:title>Conclusion:<\/jats:title><jats:p>In FE patients, the diagnosis of mania may be overlooked, as they present with more psychotic symptoms than ME patients. The prodromal phase is characterised by high levels of stress, suicide attempts, anxiety disorders and alcohol or substance abuse. Data suggest to consider these prodromes as harmful consequences of temperamental predispositions to bipolar disorder that may concur to precipitate mania onset. Their occurrence should therefore incite clinicians to screen for the presence of such predispositions, in order to identify patients at risk of FE mania.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2010.11.001","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T09:15:39Z","timestamp":1296724539000},"page":"557-562","source":"Crossref","is-referenced-by-count":9,"title":["Baseline and prodromal characteristics of first- versus multiple-episode mania in a French cohort of bipolar 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