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S-adenosylmethionine (SAMe), a naturally occurring molecule which serves as a major methyl-donor in human cellular metabolism, is required for the synthesis and maintenance of several neurotransmitters that have been implicated in the pathophysiology and treatment of cognitive dysfunction in MDD.<\/jats:p><jats:sec id=\"S0924933800258951_abs1\" sec-type=\"other\"><jats:title>Objectives<\/jats:title><jats:p>This study is a secondary analysis of a clinical trial involving the use of adjunctive SAMe for MDD.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800258951_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Forty-six serotonin-reuptake inhibitor (SRI) non-responders with MDD enrolled in a 6-week, double-blind, randomized trial of adjunctive oral SAMe were administered the self-rated cognitive and physical symptoms questionnaire (CPFQ), a validated measure of cognitive as well as physical symptoms of MDD, before and after treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800258951_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There was a greater improvement in the ability to recall information (<jats:italic>P<\/jats:italic> = 0.04) and a trend towards statistical significance for greater improvement in word-finding (<jats:italic>P<\/jats:italic> = 0.09) for patients who received adjunctive SAMe than placebo. None of the remaining five items reached statistical significance.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800258951_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>These preliminary data suggest that SAMe can improve memory-related cognitive symptoms in depressed patients, and warrant replication.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2011.03.006","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T02:47:47Z","timestamp":1309056467000},"page":"518-521","source":"Crossref","is-referenced-by-count":17,"title":["Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder"],"prefix":"10.1017","volume":"27","author":[{"given":"Y.","family":"Levkovitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Alpert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.E.","family":"Brintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mischoulon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.I.","family":"Papakostas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"S0924933800258951_bib1","volume-title":"Diagnostic and statistical manual of mental disorders.","year":"1994"},{"key":"S0924933800258951_bib6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982630"},{"key":"S0924933800258951_bib23","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09081198"},{"key":"S0924933800258951_bib4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90507-5"},{"key":"S0924933800258951_bib12","first-page":"338","volume-title":"ECDEU Assessment Manual for Psychopharmacology, revised. 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