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We hypothesized that non-response to risperidone or placebo in individuals with co-occurring BD and anxiety symptoms would be associated with a more severe clinical course of BD, and certain demographic variables. This study was a secondary analysis of a randomized, double-blind, parallel, 8-week study comparing risperidone monotherapy and placebo in individuals with BD plus current panic disorder, current generalized anxiety disorder (GAD), or lifetime panic disorder (<jats:italic>n<\/jats:italic>= 111) [31]. We compared clinical characteristics of responders (50% improvement on the Hamilton Anxiety Scale [HAM-A]) and non-responders as well as remitters (HAM-A &lt; 7) and non-remitters in risperidone treatment (<jats:italic>n<\/jats:italic>= 54) and placebo (<jats:italic>n<\/jats:italic>= 57) groups. For non-responders in the risperidone group, co-occurring lifetime panic disorder was significantly more common than for non-responders in the placebo group. Apart from this, no significant differences in course of illness or demographics were found either between or across groups for patients with BD and co-occurring anxiety symptoms receiving risperidone or placebo in this acute phase study.<\/jats:p>","DOI":"10.1016\/j.eurpsy.2011.08.001","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T06:22:56Z","timestamp":1363328576000},"page":"190-196","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety 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