{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:24:15Z","timestamp":1768422255555,"version":"3.49.0"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"unspecified","delay-in-days":2145,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800241515_abs1\" sec-type=\"other\"><jats:title>Purpose:<\/jats:title><jats:p>To test whether firstly, different parental rearing components were associated with different dimensions of psychiatric symptoms in adulthood, secondly<jats:italic>BDNF<\/jats:italic>-Val66Met polymorphism moderated this association and thirdly, this association was due to genetic confounding.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800241515_abs2\" sec-type=\"other\"><jats:title>Method:<\/jats:title><jats:p>Perceived parental rearing according to Parental Bonding Instrument (PBI), psychiatric symptoms evaluated with the Brief Symptom Inventory (BSI) and the<jats:italic>BDNF-<\/jats:italic>Val66Met polymorphism were analyzed in a sample of 232 adult twins from the general population.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800241515_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>In the whole sample, paternal care was negatively associated with depression. Maternal overprotection was positively associated with paranoid ideation, obsession-compulsion and somatization. Gene-environment interaction effects were detected between the<jats:italic>BDNF<\/jats:italic>-Val66Met polymorphism and maternal care on phobic anxiety, paternal care on hostility, maternal overprotection on somatization and paternal overprotection also in somatization. In the subsample of MZ twins, intrapair differences in maternal care were associated with anxiety, paranoid ideation and somatization.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800241515_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>Met carriers were, in general, more sensitive to the effects of parental rearing compared to Val\/Val carriers in relation to anxiety and somatization. Contra-intuitively, our findings suggest that high rates of maternal care might be of risk for Met carriers regarding anxiety. Results from analyses controlling for genetic confounding were in line with this finding.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2014.03.001","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T09:49:50Z","timestamp":1398332990000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The<i>BDNF<\/i>-Val66Met polymorphism modulates parental rearing effects on adult psychiatric symptoms: A community twin-based 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