{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:20:38Z","timestamp":1770506438516,"version":"3.49.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"unspecified","delay-in-days":1931,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800128378_abs1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the efficacy of lurasidone for schizophrenia using an established five-factor model of the Positive and Negative Syndrome Scale (PANSS).<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800128378_abs2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>Patient-level data were pooled from five randomized, double-blind, placebo-controlled, 6-week studies of lurasidone (fixed doses, 40\u2013160 mg\/d) for patients with an acute exacerbation of schizophrenia. Changes in five established PANSS factors were assessed using mixed-model repeated measures analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800128378_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Compared with placebo (<jats:italic>n<\/jats:italic> = 496), lurasidone (<jats:italic>n<\/jats:italic> = 1029, dose groups pooled) significantly improved the PANSS total score at Week 6 (\u221222.6 vs. \u221212.8; <jats:italic>P<\/jats:italic> &lt; 0.001; effect size, 0.45), as well as all factor scores (<jats:italic>P<\/jats:italic> &lt; 0.001 for each): positive symptoms (\u22128.4 vs. \u22126.0; effect size, 0.43), negative symptoms (\u22125.2 vs. \u22123.3; effect size, 0.33), disorganized thought (\u22124.9 vs. \u22122.8; effect size, 0.42), hostility\/excitement (\u22122.7 vs. \u22121.6; effect size, 0.31), and depression\/anxiety (\u22123.2 vs. \u22122.3; effect size, 0.31). Separation from placebo occurred at Week 1 for the positive symptoms, disorganized thought, and hostility\/excitement factors and at Week 2 for the other factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800128378_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>In this pooled analysis of short-term studies in patients with acute schizophrenia, lurasidone demonstrated significant improvement for each of the five PANSS factor scores, indicating effectiveness across the spectrum of schizophrenia symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T13:28:02Z","timestamp":1412429282000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of lurasidone across five symptom dimensions of schizophrenia: Pooled analysis of short-term, placebo-controlled studies"],"prefix":"10.1017","volume":"30","author":[{"given":"A.","family":"Loebel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cucchiaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pikalov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Marder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"S0924933800128378_bib0005","unstructured":"[1] American Psychiatric Association. 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