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Polymorphisms of leptin, serotonin receptor HTR2 C and adiponectin genes have been associated with antipsychotic-induced weight gain and metabolic comorbidity. However, the results of the studies so far are inconclusive. The aim of the present study was first to test for a possible role of serum leptin and adiponectin levels as a marker of weight gain in association with inflammatory cytokines\/adipokines (IL-6, IL-1Ra, hs-CRP and adipsin), and second to study associations between SNPs LEP rs7799039 (-2548 A\/G), ADIPOQ rs1501299 and HTR2 C rs1414334 and weight gain and levels of leptin and adiponectin, in 190 patients with schizophrenia on clozapine treatment, with retrospectively assessed weight change and cross-sectionally measured cytokine levels. A strong association was found between serum levels of leptin and weight gain and cytokines\/adipokines related to metabolic comorbidity, especially among female patients (in women leptin vs. weight gain, IL-6 and IL-1Ra,<jats:italic>P<\/jats:italic>&lt; 0.001; in men leptin vs. weight gain,<jats:italic>P<\/jats:italic>= 0.026, leptin vs. IL-1Ra,<jats:italic>P<\/jats:italic>&lt; 0.001). In male patients low adiponectin level was a more specific marker of clozapine-induced weight gain (<jats:italic>P<\/jats:italic>= 0.037). The results of the present study do not support a major role of SNPs LEP rs7799039, ADIPOQ rs1501299 and HTR2 C rs1414334 in the regulation of weight gain or association of serum levels of leptin and adiponectin and corresponding studied SNPs in patients with schizophrenia on clozapine treatment.<\/jats:p>","DOI":"10.1016\/j.eurpsy.2014.08.006","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T14:42:21Z","timestamp":1412433741000},"page":"296-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Association Study of the HTR2C, Leptin and Adiponectin Genes and Serum Marker Analyses in Clozapine Treated Long-Term Patients with Schizophrenia"],"prefix":"10.1017","volume":"30","author":[{"given":"J.-P.","family":"Klemettil\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kampman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Viikki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Moilanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mononen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"S0924933800191126_bib0390","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-13-40"},{"key":"S0924933800191126_bib0385","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.148"},{"key":"S0924933800191126_bib0380","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.041723"},{"key":"S0924933800191126_bib0365","doi-asserted-by":"publisher","DOI":"10.1159\/000122267"},{"key":"S0924933800191126_bib0360","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.03.010"},{"key":"S0924933800191126_bib0355","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181fa2a6f"},{"key":"S0924933800191126_bib0350","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601644"},{"key":"S0924933800191126_bib0335","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31827d145a"},{"key":"S0924933800191126_bib0325","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.07.006"},{"key":"S0924933800191126_bib0290","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/93573"},{"key":"S0924933800191126_bib0280","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.66"},{"key":"S0924933800191126_bib0250","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.04.038"},{"key":"S0924933800191126_bib0245","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/572848"},{"key":"S0924933800191126_bib0240","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00191-7"},{"key":"S0924933800191126_bib0225","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200519001-00001"},{"key":"S0924933800191126_bib0205","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181934462"},{"key":"S0924933800191126_bib0200","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.08.010"},{"key":"S0924933800191126_bib0195","first-page":"316","article-title":"-2584G\/A 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