{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:21:59Z","timestamp":1791264119072,"version":"4.1.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"unspecified","delay-in-days":1900,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800191023_abs1\" sec-type=\"other\"><jats:title>Background:<\/jats:title><jats:p>Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients\u2019 affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800191023_abs2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38 \u00b1 11; females: 16, 61%).<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800191023_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex (<jats:italic>P<\/jats:italic> &lt; 0.005). Our BPD subjects displayed a symmetric distribution of anomalies in the dorsal aspect of the cortical mantle, but a wider involvement of the left hemisphere in the mesial aspect in terms of lower density. A few restricted regions of higher density were detected in the right hemisphere. All regions remained significant after correction for multiple comparisons via permutation testing.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800191023_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>BPD patients feature specific morphology of the cerebral structures involved in cognitive and emotional processing and social cognition\/mentalization, consistent with clinical and functional data.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2014.11.009","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T14:01:21Z","timestamp":1420207281000},"page":"221-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Abnormalities in Cortical Gray Matter Density in Borderline Personality Disorder"],"prefix":"10.1017","volume":"30","author":[{"given":"R.","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lanfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pievani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.E.","family":"Rasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cavedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cotelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Beneduce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bignotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.R.","family":"Magni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rillosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Magnaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.","family":"Frisoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"S0924933800191023_bib0330","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.11.020"},{"key":"S0924933800191023_bib0325","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03176.x"},{"key":"S0924933800191023_bib0290","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(200002)9:2<81::AID-HBM3>3.0.CO;2-8"},{"key":"S0924933800191023_bib0285","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.040"},{"key":"S0924933800191023_bib0275","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01743-2"},{"key":"S0924933800191023_bib0265","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.1.17"},{"key":"S0924933800191023_bib0255","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0730"},{"key":"S0924933800191023_bib0245","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(03)00023-4"},{"key":"S0924933800191023_bib0240","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"S0924933800191023_bib0130","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.029"},{"key":"S0924933800191023_bib0210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1999.tb10850.x"},{"key":"S0924933800191023_bib0185","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"S0924933800191023_bib0180","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh172"},{"key":"S0924933800191023_bib0175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.07.015"},{"key":"S0924933800191023_bib0335","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss028"},{"key":"S0924933800191023_bib0155","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.01.007"},{"key":"S0924933800191023_bib0140","volume-title":"Meta-analysis of structural brain differences in bipolar disorder: the ENIGMA-Bipolar Disorder Project","author":"Hibar","year":"2013"},{"key":"S0924933800191023_bib0135","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01075-7"},{"key":"S0924933800191023_bib0125","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0924933800191023_bib0115","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2006.57.12.1778"},{"key":"S0924933800191023_bib0095","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.011"},{"key":"S0924933800191023_bib0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.12.013"},{"key":"S0924933800191023_bib0145","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707001626"},{"key":"S0924933800191023_bib0270","volume-title":"Manual for the State-Trait Anxiety Inventory (Form Y)","author":"Spielberger","year":"1983"},{"key":"S0924933800191023_bib0280","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003"},{"key":"S0924933800191023_bib0060","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.11.1954"},{"key":"S0924933800191023_bib0260","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.2005.19.5.487"},{"key":"S0924933800191023_bib0075","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1120"},{"key":"S0924933800191023_bib0300","article-title":"A Large-Scale Meta-Analysis of Subcortical Brain Volume Abnormalities in Schizophrenia via the ENIGMA Consortium","author":"van Erp","year":"2013","journal-title":"Society for Biological Psychiatry (SOBP)"},{"key":"S0924933800191023_bib0025","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.6.871"},{"key":"S0924933800191023_bib0195","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.11.054"},{"key":"S0924933800191023_bib0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.070"},{"key":"S0924933800191023_bib0165","doi-asserted-by":"publisher","DOI":"10.1117\/12.185176"},{"key":"S0924933800191023_bib0085","volume-title":"Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II)","author":"First","year":"1994"},{"key":"S0924933800191023_bib0190","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579405050431"},{"key":"S0924933800191023_bib0220","volume-title":"Disturbo Borderline di Personalit\u00e0: continuit\u00e0 e discontinuit\u00e0 nel trattamento","author":"Rossi","year":"2010"},{"key":"S0924933800191023_bib0105","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324915"},{"key":"S0924933800191023_bib0015","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90006-X"},{"key":"S0924933800191023_bib0040","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl051"},{"key":"S0924933800191023_bib0235","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00297-0"},{"key":"S0924933800191023_bib0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.04.003"},{"key":"S0924933800191023_bib0090","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders\u2013Patient Edition (SCID-I\/P)","author":"First","year":"1994"},{"key":"S0924933800191023_bib0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.08.007"},{"key":"S0924933800191023_bib0005","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)56020-0"},{"key":"S0924933800191023_bib0315","first-page":"383","article-title":"Reduced amygdala and hippocampus size in trauma-exposed women with borderline personality disorder and without posttraumatic stress disorder","volume":"34","author":"Weniger","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"S0924933800191023_bib0050","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18037"},{"key":"S0924933800191023_bib0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.11.011"},{"key":"S0924933800191023_bib0080","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.181.3.220"},{"key":"S0924933800191023_bib0010","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01501-1"},{"key":"S0924933800191023_bib0295","volume-title":"A Prospective Meta-Analysis of Subcortical Brain Volumes in Schizophrenia via the ENIGMA Consortium","author":"Turner","year":"2013"},{"key":"S0924933800191023_bib0305","doi-asserted-by":"publisher","DOI":"10.1109\/42.811270"},{"key":"S0924933800191023_bib0110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01582.x"},{"key":"S0924933800191023_bib0230","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.07.002"},{"key":"S0924933800191023_bib0215","first-page":"1","article-title":"Differential hemispheric lateralization of primary and social emotions","volume":"7","author":"Ross","year":"1994","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"S0924933800191023_bib0225","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.12.004"},{"key":"S0924933800191023_bib0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.05.001"},{"key":"S0924933800191023_bib0160","doi-asserted-by":"publisher","DOI":"10.1177\/0003065110386111"},{"key":"S0924933800191023_bib0200","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324618"},{"key":"S0924933800191023_bib0205","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144230"},{"key":"S0924933800191023_bib0035","article-title":"Regional cortical thinning may be a biological marker for borderline personality disorder","author":"B\u00f8en","year":"2013","journal-title":"Acta Psychiatr Scand"},{"key":"S0924933800191023_bib0020","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301507"},{"key":"S0924933800191023_bib0310","doi-asserted-by":"publisher","DOI":"10.1109\/42.811268"},{"key":"S0924933800191023_bib0170","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3083"},{"key":"S0924933800191023_bib0150","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.004"},{"key":"S0924933800191023_bib0250","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198569183.001.0001"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933814006506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933814006506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933800191023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T08:47:05Z","timestamp":1587113225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933800191023\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0924933800191023"],"URL":"https:\/\/doi.org\/10.1016\/j.eurpsy.2014.11.009","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormalities in cortical gray matter density in borderline personality disorder","name":"articletitle","label":"Article Title"},{"value":"European Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eurpsy.2014.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}