{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:14Z","timestamp":1761895994776},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"unspecified","delay-in-days":1780,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800191266_abs1\" sec-type=\"other\"><jats:title>Background:<\/jats:title><jats:p>Joint hypermobility syndrome (JHS) has repeatedly been associated with anxiety and anxiety disorders, fibromyalgia, irritable bowel syndrome and temporomandibular joint disorder. However, the neural underpinnings of these associations still remain unclear. This study explored brain responses to facial visual stimuli with emotional cues using fMRI techniques in general population with different ranges of hypermobility.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800191266_abs2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>Fifty-one non-clinical volunteers (33 women) completed state and trait anxiety questionnaire measures, were assessed with a clinical examination for hypermobility (Beighton system) and performed an emotional face processing paradigm during functional neuroimaging.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800191266_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Trait anxiety scores did significantly correlate with both state anxiety and hypermobility scores. BOLD signals of the hippocampus did positively correlate with hypermobility scores for the crying faces versus neutral faces contrast in ROI analyses. No results were found for any of the other studied ROIs. Additionally, hypermobility scores were also associated with other key affective processing areas (i.e. the middle and anterior cingulate gyrus, fusiform gyrus, parahippocampal region, orbitofrontal cortex and cerebellum) in the whole brain analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800191266_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>Hypermobility scores are associated with trait anxiety and higher brain responses to emotional faces in emotion processing brain areas (including hippocampus) described to be linked to anxiety and somatic symptoms. These findings increase our understanding of emotion processing in people bearing this heritable variant of collagen and the mechanisms through which vulnerability to anxiety and somatic symptoms arises in this population.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2015.01.004","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T22:02:52Z","timestamp":1423864972000},"page":"454-458","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies"],"prefix":"10.1017","volume":"30","author":[{"given":"N.","family":"Mallorqu\u00ed-Bagu\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bulbena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ro\u00e9-Vellv\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hoekzema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Barba-M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fauquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pailhez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Vilarroya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"S0924933800191266_bib0185","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-3900-3"},{"key":"S0924933800191266_bib0255","doi-asserted-by":"crossref","first-page":"453","DOI":"10.31887\/DCNS.2011.13.4\/kholzschneider","article-title":"Neuroimaging in anxiety disorders","volume":"13","author":"Holzschneider","year":"2011","journal-title":"Dialogues Clin Neurosci"},{"key":"S0924933800191266_bib0175","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.03.008"},{"key":"S0924933800191266_bib0240","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.025"},{"key":"S0924933800191266_bib0295","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20208"},{"key":"S0924933800191266_bib0330","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.10.048"},{"key":"S0924933800191266_bib0315","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.03.022"},{"key":"S0924933800191266_bib0310","volume-title":"Cuestionario de Ansiedad Estado-Rasgo","author":"Spielberger","year":"1986"},{"key":"S0924933800191266_bib0305","first-page":"274","article-title":"The relationship between benign joint hypermobility syndrome and psychological distress: a systematic review and meta-analyses","author":"Smith","year":"2013","journal-title":"Rheumatology"},{"key":"S0924933800191266_bib0290","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"S0924933800191266_bib0270","first-page":"1162","article-title":"Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility","volume":"14","author":"Mallorqu\u00ed-Bagu\u00e9","year":"2014","journal-title":"Front Psychol"},{"key":"S0924933800191266_bib0250","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00006-7"},{"key":"S0924933800191266_bib0325","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2009.21.3.245"},{"key":"S0924933800191266_bib0300","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.12.025"},{"key":"S0924933800191266_bib0245","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0907"},{"key":"S0924933800191266_bib0210","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.45.5.432"},{"key":"S0924933800191266_bib0180","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.2.163"},{"key":"S0924933800191266_bib0320","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(00)00082-9"},{"key":"S0924933800191266_bib0170","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9188-x"},{"key":"S0924933800191266_bib0265","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.09.032"},{"key":"S0924933800191266_bib0215","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.03.004"},{"key":"S0924933800191266_bib0285","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7167"},{"key":"S0924933800191266_bib0225","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(01)00060-3"},{"key":"S0924933800191266_bib0205","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90514-4"},{"key":"S0924933800191266_bib0280","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170800500X"},{"key":"S0924933800191266_bib0220","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.092460"},{"key":"S0924933800191266_bib0190","doi-asserted-by":"publisher","DOI":"10.1016\/S1516-4446(12)70054-5"},{"key":"S0924933800191266_bib0200","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.077"},{"key":"S0924933800191266_bib0235","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048107"},{"key":"S0924933800191266_bib0230","volume-title":"Versi\u00f3n Cl\u00ednica (SCID-I)","author":"First","year":"1999"},{"key":"S0924933800191266_bib0275","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.211"},{"key":"S0924933800191266_bib0260","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"S0924933800191266_bib0195","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1220"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933815000486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933815000486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933800191266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T17:53:38Z","timestamp":1651254818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933800191266\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0924933800191266"],"URL":"https:\/\/doi.org\/10.1016\/j.eurpsy.2015.01.004","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies","name":"articletitle","label":"Article Title"},{"value":"European Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eurpsy.2015.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}