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Maps of the electric field strength relative to an estimated neural activation threshold were used to evaluate the stimulation strength and focality in specific brain regions of interest for these ECT and MST paradigms and various stimulus current amplitudes.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800066281_sec0015\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The standard ECT configurations and current amplitude of 800\u2013900 mA produced the strongest overall stimulation with median of 1.8\u20132.9 times neural activation threshold and more than 94% of the brain volume stimulated at suprathreshold level. All standard ECT electrode placements exposed the hippocampi to suprathreshold electric field, although there were differences across modalities with bilateral and right unilateral producing respectively the strongest and weakest hippocampal stimulation. MST stimulation is up to 9 times weaker compared to conventional ECT, resulting in direct activation of only 21% of the brain. Reducing the stimulus current amplitude can make ECT as focal as MST.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800066281_sec0020\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The relative differences in electric field strength may be a contributing factor for the cognitive sparing observed with right unilateral compared to bilateral ECT, and MST compared to right unilateral ECT. These simulations could help understand the mechanisms of seizure therapies and develop interventions with superior risk\/benefit ratio.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2016.03.003","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T11:32:28Z","timestamp":1466163148000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Comparison of electric field strength and spatial distribution of electroconvulsive therapy and magnetic seizure therapy in a realistic human head 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