{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T03:24:58Z","timestamp":1786245898801,"version":"build-2736575974"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":1177,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924933800068322_abst0005\" sec-type=\"other\"><jats:title>Objectives<\/jats:title><jats:p>Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800068322_abst0010\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We used data on 2957\u00a0participants from a large birth cohort (Avon longitudinal study of parents and children [ALSPAC]). The primary outcome of interest was hypomania, and the secondary outcome was \u201chypomania plus previous psychotic experiences (PE)\u201d. Maternally-reported smoking during pregnancy, paternal smoking and exposure to environmental tobacco smoke (ETS) in childhood were the exposures of interest. Multivariable logistic regression was used and estimates of association were adjusted for socio-economic, lifestyle and obstetric factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800068322_abst0015\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There was weak evidence of an association between exposure to maternal smoking in utero and lifetime hypomania. However, there was a strong association of maternal smoking during pregnancy within the sub-group of individuals with hypomania who had also experienced psychotic symptoms (OR = 3.45; 95% CI: 1.49\u20137.98;<jats:italic>P<\/jats:italic>= 0.004). There was no association between paternal smoking, or exposure to ETS during childhood, and hypomania outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800068322_abst0020\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Exposure to smoking in utero may be a risk factor for more severe forms of psychopathology on the mood-psychosis spectrum, rather than DSM-defined bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T16:00:33Z","timestamp":1478016033000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort 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