{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:36:52Z","timestamp":1793317012049,"version":"4.5.0"},"reference-count":111,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933800191837_abs1\" sec-type=\"other\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability to develop the disorder but the risk factors accounting for this accrued risk are undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800191837_abs2\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Systematic review of associations between genetic or environmental risk factors for psychosis that are widely established in the literature and UHR state, based on comparisons to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800191837_abs3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-four studies encompassing 170\u00a0independent datasets and 54\u00a0risk factors were included. There were no studies on association between genetic or epigenetic risk factors and the UHR state that met the inclusion criteria. UHR subjects were more likely to show obstetric complications, tobacco use, physical inactivity, childhood trauma\/emotional abuse\/physical neglect, high perceived stress, childhood and adolescent low functioning, affective comorbidities, male gender, single status, unemployment and low educational level as compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800191837_abs4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increased vulnerability of UHR subjects can be related to environmental risk factors like childhood trauma, adverse life events and affective dysfunction. The role of genetic and epigenetic risk factors awaits clarification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.eurpsy.2016.09.003","type":"journal-article","created":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T18:58:15Z","timestamp":1481914695000},"page":"65-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":286,"title":["Deconstructing Vulnerability for Psychosis: Meta-Analysis of Environmental Risk Factors for Psychosis in Subjects at Ultra High-Risk"],"prefix":"10.1017","volume":"40","author":[{"given":"P.","family":"Fusar-Poli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tantardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"De Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ramella-Cravaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kingdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kotlicka-Antczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Valmaggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Galderisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Balottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ricca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"S0924933800191837_bib0057","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.157115"},{"key":"S0924933800191837_bib0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.04.041"},{"key":"S0924933800191837_bib0044","first-page":"10","volume-title":"Nonparametric trim and fill analysis of publication bias in meta-analysis. Stata Technical Bulletin","author":"Steichen","year":"2001"},{"key":"S0924933800191837_bib0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.11.023"},{"key":"S0924933800191837_bib0028","unstructured":"[28] World health organization Risk factors 2016"},{"key":"S0924933800191837_bib0075","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv162"},{"key":"S0924933800191837_bib0063","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00353-3"},{"key":"S0924933800191837_bib0024","volume-title":"The psychosis-risk syndrome. Handbook for diagnosis and follow-up","author":"McGlashan","year":"2010"},{"key":"S0924933800191837_bib0070","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.18632\/oncotarget.3129","article-title":"The influence of marital status on stage at diagnosis and survival of patients with colorectal cancer","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget."},{"key":"S0924933800191837_bib0095","doi-asserted-by":"publisher","DOI":"10.1037\/a0034085"},{"key":"S0924933800191837_bib0015","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13030418"},{"key":"S0924933800191837_bib0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.11.026"},{"key":"S0924933800191837_bib0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.08.028"},{"key":"S0924933800191837_bib0105","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.06.005"},{"key":"S0924933800191837_bib0041","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900202"},{"key":"S0924933800191837_bib0092","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001262"},{"key":"S0924933800191837_bib0010","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2015-102295"},{"key":"S0924933800191837_bib0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.05.010"},{"key":"S0924933800191837_bib0049","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-015-0692-6"},{"key":"S0924933800191837_bib0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.08.029"},{"key":"S0924933800191837_bib0009","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0094"},{"key":"S0924933800191837_bib0101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2011.00280.x"},{"key":"S0924933800191837_bib0099","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712000803"},{"key":"S0924933800191837_bib0072","first-page":"149","article-title":"The influence of marital status on the social dysfunction of schizophrenia patients in community","volume":"2","author":"Xue-jie","year":"2015","journal-title":"Int J Nurs Sci"},{"key":"S0924933800191837_bib0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.05.006"},{"key":"S0924933800191837_bib0052","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.28"},{"key":"S0924933800191837_bib0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.03.022"},{"key":"S0924933800191837_bib0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.01.023"},{"key":"S0924933800191837_bib0043","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386"},{"key":"S0924933800191837_bib0090","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-014-0361-1"},{"key":"S0924933800191837_bib0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2013.05.015"},{"key":"S0924933800191837_bib0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.08.016"},{"key":"S0924933800191837_bib0023","volume-title":"Comprehensive assessment of at risk mental state","author":"Yung","year":"2006"},{"key":"S0924933800191837_bib0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.05.053"},{"key":"S0924933800191837_bib0064","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12382"},{"key":"S0924933800191837_bib0022","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"S0924933800191837_bib0036","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.117.1.167"},{"key":"S0924933800191837_bib0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.03.034"},{"key":"S0924933800191837_bib0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.11.002"},{"key":"S0924933800191837_bib0003","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2324"},{"key":"S0924933800191837_bib0001","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/22.2.283"},{"key":"S0924933800191837_bib0002","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20250"},{"key":"S0924933800191837_bib0004","unstructured":"[4] England, N.H.S. Achieving better access to mental health services by 2020 2014 https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/361648\/mental-health-access.pdf"},{"key":"S0924933800191837_bib0005","unstructured":"[5] Department of Health U. Government U. Achieving better access to mental health services by 2020 2014"},{"key":"S0924933800191837_bib0006","volume-title":"Psychosis and schizophrenia in children and young people: recognition and management","author":"Nice","year":"2013"},{"key":"S0924933800191837_bib0007","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032813-153645"},{"key":"S0924933800191837_bib0008","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs060"},{"key":"S0924933800191837_bib0027","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"S0924933800191837_bib0012","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031660"},{"key":"S0924933800191837_bib0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.03.004"},{"key":"S0924933800191837_bib0016","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv091"},{"key":"S0924933800191837_bib0061","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs155"},{"key":"S0924933800191837_bib0017","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn117"},{"key":"S0924933800191837_bib0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.11.015"},{"key":"S0924933800191837_bib0019","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-016-1182-y"},{"key":"S0924933800191837_bib0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.02.004"},{"key":"S0924933800191837_bib0021","doi-asserted-by":"publisher","DOI":"10.1007\/s40211-016-0179-9"},{"key":"S0924933800191837_bib0025","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1038155"},{"key":"S0924933800191837_bib0056","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171500135X"},{"key":"S0924933800191837_bib0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.03.004"},{"key":"S0924933800191837_bib0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.09.020"},{"key":"S0924933800191837_bib0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.09.007"},{"key":"S0924933800191837_bib0031","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0562-2"},{"key":"S0924933800191837_bib0032","doi-asserted-by":"crossref","first-page":"69","DOI":"10.31887\/DCNS.2005.7.1\/kdean","article-title":"Environmental risk factors for psychosis","volume":"7","author":"Dean","year":"2005","journal-title":"Dialogues Clin Neurosci."},{"key":"S0924933800191837_bib0034","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1592"},{"key":"S0924933800191837_bib0035","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5061"},{"key":"S0924933800191837_bib0037","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0800800102"},{"key":"S0924933800191837_bib0039","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7304.101"},{"key":"S0924933800191837_bib0040","first-page":"89","article-title":"A nonparametric \u201cTrim and Fill\u201d method of accounting for publication bias in meta-analysis","volume":"95","author":"Duval","year":"2000","journal-title":"J Am Stat Assoc"},{"key":"S0924933800191837_bib0042","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0800800403"},{"key":"S0924933800191837_bib0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.010"},{"key":"S0924933800191837_bib0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.04.014"},{"key":"S0924933800191837_bib0038","volume-title":"Practical meta-analysis","author":"Lipsey","year":"2000"},{"key":"S0924933800191837_bib0050","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr164"},{"key":"S0924933800191837_bib0051","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2313"},{"key":"S0924933800191837_bib0053","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12070940"},{"key":"S0924933800191837_bib0055","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2012.00391.x"},{"key":"S0924933800191837_bib0058","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2253"},{"key":"S0924933800191837_bib0059","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs136"},{"key":"S0924933800191837_bib0060","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw055"},{"key":"S0924933800191837_bib0062","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00152-2"},{"key":"S0924933800191837_bib0065","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-012-0545-2"},{"key":"S0924933800191837_bib0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.11.039"},{"key":"S0924933800191837_bib0068","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1270"},{"key":"S0924933800191837_bib0071","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2008.00074.x"},{"key":"S0924933800191837_bib0074","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282b721fe"},{"key":"S0924933800191837_bib0076","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw098"},{"key":"S0924933800191837_bib0077","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv190"},{"key":"S0924933800191837_bib0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.07.050"},{"key":"S0924933800191837_bib0082","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715000227"},{"key":"S0924933800191837_bib0083","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12107"},{"key":"S0924933800191837_bib0084","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12384"},{"key":"S0924933800191837_bib0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.10.004"},{"key":"S0924933800191837_bib0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.07.046"},{"key":"S0924933800191837_bib0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.03.030"},{"key":"S0924933800191837_bib0093","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.05.026"},{"key":"S0924933800191837_bib0096","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12022"},{"key":"S0924933800191837_bib0098","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr098"},{"key":"S0924933800191837_bib0100","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711001929"},{"key":"S0924933800191837_bib0103","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10081209"},{"key":"S0924933800191837_bib0104","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.595684"},{"key":"S0924933800191837_bib0106","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp027"},{"key":"S0924933800191837_bib0108","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.05.011"},{"key":"S0924933800191837_bib0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.10.012"},{"key":"S0924933800191837_bib0086","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12115"},{"key":"S0924933800191837_bib0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.01.013"},{"key":"S0924933800191837_bib0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.09.002"},{"key":"S0924933800191837_bib0011","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1472"},{"key":"S0924933800191837_bib0069","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12311"},{"key":"S0924933800191837_bib0094","doi-asserted-by":"publisher","DOI":"10.1017\/S095457941300045X"},{"key":"S0924933800191837_bib0109","doi-asserted-by":"publisher","DOI":"10.1080\/00048670802203459"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933816301389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933816301389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933800191837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T09:14:23Z","timestamp":1658049263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933800191837\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":111,"alternative-id":["S0924933800191837"],"URL":"https:\/\/doi.org\/10.1016\/j.eurpsy.2016.09.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727173780.793567543","asserted-by":"object"}]},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deconstructing vulnerability for psychosis: Meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk","name":"articletitle","label":"Article Title"},{"value":"European Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eurpsy.2016.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}