{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:22:09Z","timestamp":1790126529694,"version":"4.0.1"},"reference-count":56,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"unspecified","delay-in-days":33,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with schizophrenia exhibit a reduced life expectancy. Although unhealthy lifestyle or suicide risk plays a role, the main causes are diverse medical conditions such as cardiovascular diseases, type 2 diabetes mellitus and metabolic syndrome. Albeit pharmacological secondary side effects might also trigger previous conditions, studies in na\u00efve patients reflect diverse anomalies at the onset. Patients with a first episode of psychosis, display a wide scope of metabolic abnormalities, ranging from normality till pathological values depending on the parameters studied. We attempted to evaluate the metabolic syndrome and glycemic homeostasis in a subset of antipsychotic-na\u00efve patients with a first episode of non-affective psychosis. Patients (<jats:italic>n<\/jats:italic>= 84) showed a similar prevalence of metabolic syndrome compared with a matched control sample (<jats:italic>n<\/jats:italic>= 98) (6% vs 4%,<jats:italic>P<\/jats:italic>= 0.562), while glucose homeostasis values differed significantly (14% vs. 5%,<jats:italic>P<\/jats:italic>= 0.034). Our results suggest that metabolic syndrome is not a useful clinical condition to be evaluated in patients before pharmacological treatment. Abnormal glycemic homeostasis at the onset of the disease requires specific diagnostic tools and preventive measures in order to avoid future cardiovascular events. New strategies must be implemented in order to evaluate the cardiovascular risk and subsequent morbidity in patients at the onset of the disease.<\/jats:p>","DOI":"10.1016\/j.eurpsy.2016.10.001","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T19:30:49Z","timestamp":1486150249000},"page":"42-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Metabolic syndrome or glucose challenge in first episode of psychosis?"],"prefix":"10.1017","volume":"41","author":[{"given":"C.","family":"Garcia-Rizo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fernandez-Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Meseguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mezquida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bioque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Penades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Parellada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"S0924933800192673_bib0375","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.08.009"},{"key":"S0924933800192673_bib0450","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq058"},{"key":"S0924933800192673_bib0545","first-page":"4","article-title":"Assessing clinical and functional outcomes in a gene\u2013environment interaction study in first episode of psychosis (PEPs)","volume":"6","author":"Bernardo","year":"2013","journal-title":"Rev Psiquiatr Y Salud Ment (English Ed)"},{"key":"S0924933800192673_bib0525","article-title":"Obstetric complications as risk factors for schizophrenia spectrum psychoses in offspring of mothers with psychotic disorder","author":"Suvisaari","year":"2012","journal-title":"Schizophr Bull"},{"key":"S0924933800192673_bib0485","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.07.041"},{"key":"S0924933800192673_bib0480","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.09.005"},{"key":"S0924933800192673_bib0465","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2013.08.014"},{"key":"S0924933800192673_bib0475","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1135"},{"key":"S0924933800192673_bib0445","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.052605"},{"key":"S0924933800192673_bib0415","doi-asserted-by":"publisher","DOI":"10.3109\/08039488.2011.621977"},{"key":"S0924933800192673_bib0405","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.01.028"},{"key":"S0924933800192673_bib0400","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.05.036"},{"key":"S0924933800192673_bib0395","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.05.010"},{"key":"S0924933800192673_bib0370","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31820fcea3"},{"key":"S0924933800192673_bib0330","first-page":"251","article-title":"Garc\u00eda-Portilla Gonz\u00e1lez MP. [Consensus on physical health of patients with schizophrenia from the Spanish Societies of Psychiatry and Biological Psychiatry]","volume":"36","author":"S\u00e1iz","year":"2008","journal-title":"Actas Esp Psiquiatr"},{"key":"S0924933800192673_bib0315","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2013.04.003"},{"key":"S0924933800192673_bib0295","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798008186"},{"key":"S0924933800192673_bib0290","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13065su1.05"},{"key":"S0924933800192673_bib0380","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr148"},{"key":"S0924933800192673_bib0515","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055176"},{"key":"S0924933800192673_bib0495","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.08.056"},{"key":"S0924933800192673_bib0535","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn096"},{"key":"S0924933800192673_bib0490","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.011"},{"key":"S0924933800192673_bib0500","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-13-47"},{"key":"S0924933800192673_bib0345","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12075"},{"key":"S0924933800192673_bib0520","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12309"},{"key":"S0924933800192673_bib0460","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1087"},{"key":"S0924933800192673_bib0540","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs050"},{"key":"S0924933800192673_bib0300","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3690"},{"key":"S0924933800192673_bib0360","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.07.014"},{"key":"S0924933800192673_bib0365","first-page":"22","article-title":"Antipsychotic-induced weight gain: a review of the literature","volume":"62","author":"Allison","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"S0924933800192673_bib0385","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.04.028"},{"key":"S0924933800192673_bib0320","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2.596"},{"key":"S0924933800192673_bib0455","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.02.001"},{"key":"S0924933800192673_bib0310","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.05.009"},{"key":"S0924933800192673_bib0305","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.04.019"},{"key":"S0924933800192673_bib0430","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31827ad512"},{"key":"S0924933800192673_bib0335","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.084665"},{"key":"S0924933800192673_bib0285","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032813-153657"},{"key":"S0924933800192673_bib0505","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12194"},{"key":"S0924933800192673_bib0470","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.02.015"},{"key":"S0924933800192673_bib0440","doi-asserted-by":"crossref","first-page":"189","DOI":"10.47102\/annals-acadmedsg.V31N2p189","article-title":"Comparing fasting plasma glucose against two-hour post-load glucose concentrations for the diagnosis of diabetes mellitus and glucose intolerance in Singaporean hospital patients","volume":"31","author":"Chen","year":"2002","journal-title":"Ann Acad Med Singapore"},{"key":"S0924933800192673_bib0425","first-page":"122","article-title":"Mood and psychotic disorders and type 2 diabetes: a metabolic triad","volume":"29","author":"McIntyre","year":"2005","journal-title":"Can J Diabetes"},{"key":"S0924933800192673_bib0420","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs082"},{"key":"S0924933800192673_bib0555","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1917-3"},{"key":"S0924933800192673_bib0325","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2010.11.001"},{"key":"S0924933800192673_bib0340","first-page":"943162","article-title":"A comprehensive review on metabolic syndrome","volume":"2014","author":"Kaur","year":"2014","journal-title":"Cardiol Res Pr"},{"key":"S0924933800192673_bib0530","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.09.020"},{"key":"S0924933800192673_bib0435","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs134"},{"key":"S0924933800192673_bib0510","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.11.009"},{"key":"S0924933800192673_bib0355","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"S0924933800192673_bib0560","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr178"},{"key":"S0924933800192673_bib0550","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709991966"},{"key":"S0924933800192673_bib0390","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.03.025"},{"key":"S0924933800192673_bib0350","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"S0924933800192673_bib0410","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.10.013"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933816301560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924933816301560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933800192673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T23:50:38Z","timestamp":1749945038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933800192673\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"alternative-id":["S0924933800192673"],"URL":"https:\/\/doi.org\/10.1016\/j.eurpsy.2016.10.001","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic syndrome or glucose challenge in first episode of psychosis?","name":"articletitle","label":"Article Title"},{"value":"European Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eurpsy.2016.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}