{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:19Z","timestamp":1792785919131,"version":"4.5.0"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":996,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The Scientific and Technological Research Council of Turkey (T\u00dcB\u0130TAK) B\u0130DEB2232","id":[{"id":"https:\/\/ror.org\/04w9kkr77","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S092493380006973X_abst0005\" sec-type=\"other\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Neuropsychological impairment, including deficits in social cognition is evident in subjects at genetic high-risk for psychosis. However, findings in youth at genetic risk to bipolar disorder (BP) have been suggested to be less supportive of premorbid deficits. We aimed to conduct a meta-analysis of cognitive deficits in youth with familiar risk for bipolar disorder (FHR-BD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493380006973X_abst0010\" sec-type=\"methods\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A novel meta-analysis of FHR-BD (mean age 10\u201325), including 18 studies (786 offsprings\/siblings of patients with BD and 794 healthy controls), was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493380006973X_abst0015\" sec-type=\"results\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both general cognition (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.29, CI = 0.15\u20130.44) and social cognition (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.23, CI = 0\u20130.45) were impaired in FHR-BD. In comparison to controls, FHR-BD had significant deficits in several cognitive domains, including visual memory (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.35), verbal memory (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.21), processing speed (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.26) and sustained attention (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.36). There was no significant difference between FHR-BD and controls in planning and working memory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493380006973X_abst0020\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Cognitive deficits are evident in individuals who are at genetic high-risk for developing BD. Neurodevelopmental abnormalities are likely playing a role not only in schizophrenia but also in BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.eurpsy.2017.02.483","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T01:45:27Z","timestamp":1488505527000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["A meta-analysis of neurocognition in youth with familial high risk for bipolar 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