{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:02:12Z","timestamp":1784062932546,"version":"3.55.0"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":365,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"\u201cCompagnia di San Paolo\u201d Bank Foundation with the \u201cBando Neuroscienze\u201d grant"},{"name":"IARPsrl generic"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933800008890_abst0005\" sec-type=\"other\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800008890_abst0010\" sec-type=\"methods\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800008890_abst0015\" sec-type=\"results\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800008890_abst0020\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.eurpsy.2018.08.005","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T06:19:52Z","timestamp":1540793992000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms"],"prefix":"10.1017","volume":"55","author":[{"given":"Angela V.","family":"Spalatro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Amianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"D\u2019Agata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bergui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Abbate Daga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Secondo","family":"Fassino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Northoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"S0924933800008890_bib0210","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1405289111"},{"key":"S0924933800008890_bib0130","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517558113"},{"key":"S0924933800008890_bib0175","volume-title":"The SCL-90 manual I: scoring, administration and procedures for the SCL-90","author":"Derogatis","year":"1997"},{"key":"S0924933800008890_bib0295","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131724"},{"key":"S0924933800008890_bib0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.08.062"},{"key":"S0924933800008890_bib0030","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301443"},{"key":"S0924933800008890_bib0260","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.11.008"},{"key":"S0924933800008890_bib0035","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12318"},{"key":"S0924933800008890_bib0235","volume-title":"Co-planar stereotaxic atlas of the human brain: 3-Dimensional proportional system: an approach to cerebral imaging","author":"Talairach","year":"1988"},{"key":"S0924933800008890_bib0020","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00356-9"},{"key":"S0924933800008890_bib0275","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.08.010"},{"key":"S0924933800008890_bib0180","volume-title":"Beck depression inventory: manual","author":"Beck","year":"1996"},{"key":"S0924933800008890_bib0160","volume-title":"The Temperament and Character Inventory (TCI): a guide to its development and use center for psychobiology of personality","author":"Cloninger","year":"1996"},{"key":"S0924933800008890_bib0300","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.07.013"},{"key":"S0924933800008890_bib0040","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.120068"},{"key":"S0924933800008890_bib0065","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911855107"},{"key":"S0924933800008890_bib0015","first-page":"13","article-title":"Resistance to treatment in eating disorders: a critical challenge","volume":"7","author":"Fassino","year":"2013","journal-title":"BMC Psychiatry"},{"key":"S0924933800008890_bib0245","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.059"},{"key":"S0924933800008890_bib0010","first-page":"7","article-title":"Is anorexia nervosa a disorder of the self? 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