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We aimed to assess the effect of clinical characteristics, symptom dimensions and neuropsychological performance on psychosocial functioning and self-perceived functional impairment in DD.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800008968_abs2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>Seventy-five patients with a SCID-I confirmed diagnosis of DD underwent neurocognitive testing using a neuropsychological battery examining verbal memory, attention, working memory and executive functions. We assessed psychotic symptoms with the Positive and Negative Syndrome Scale, and calculated factor scores for four clinical dimensions: <jats:italic>Paranoid<\/jats:italic>, <jats:italic>Cognitive<\/jats:italic>, <jats:italic>Affective<\/jats:italic> and <jats:italic>Schizoid.<\/jats:italic> We conducted hierarchical linear regression models to identify predictors of psychosocial functioning, as measured with the Global Assessment of Functioning scale, and self-perceived functional impairment, as measured with the Sheehan\u2019s Disability Inventory.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800008968_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>In the final linear regression models, higher scores in the <jats:italic>Paranoid<\/jats:italic> (<jats:italic>\u03b2<\/jats:italic><jats:italic>=<\/jats:italic> 0.471, p &lt;.001, r<jats:sup>2<\/jats:sup> = 0.273) and <jats:italic>Cognitive<\/jats:italic> (<jats:italic>\u03b2<\/jats:italic> = 0.325, p &lt;.001, r<jats:sup>2<\/jats:sup> = 0.180) symptomatic dimensions and lower scores in verbal memory (<jats:italic>\u03b2<\/jats:italic> = \u22120.273, p &lt;.05, r<jats:sup>2<\/jats:sup> = 0.075) were significantly associated with poorer psychosocial functioning in patients with DD. Lower scores in verbal memory (<jats:italic>\u03b2<\/jats:italic><jats:italic>=<\/jats:italic> \u22120.337, p &lt;.01, r<jats:sup>2<\/jats:sup> = 0.158) and executive functions (<jats:italic>\u03b2<\/jats:italic><jats:italic>=<\/jats:italic> \u22120.323, p &lt;.01, r<jats:sup>2<\/jats:sup> = 0.094) were significantly associated with higher self-perceived disability.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800008968_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>Impaired verbal memory and cognitive symptoms seem to affect functionality in DD, above and beyond the severity of the paranoid idea. This suggests a potential role for cognitive interventions in the management of DD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2018.09.010","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T10:14:28Z","timestamp":1540894468000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cognition and functionality in delusional disorder"],"prefix":"10.1017","volume":"55","author":[{"given":"Covadonga M.","family":"D\u00edaz-Caneja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Cervilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Arango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique de","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"S0924933800008968_bib0125","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000893"},{"key":"S0924933800008968_bib0020","volume-title":"Psychiatrie; ein Lehrbuch f\u00fcr Studierende und \u00c4rzte. 8., vollstandig umgearb. 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