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It has been suggested that BD with a history of psychotic symptoms (BD-P) could constitute a phenotypically homogeneous subtype characterized by greater neurocognitive and functional impairments, or by a distinct trajectory of such deficits. The aim of this study was to compare the neurocognitive and functional course of euthymic BD-P, euthymic BD patients without a history of psychosis (BD-NP), stabilized patients with schizophrenia and healthy subjects, during a five-year follow-up.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800009147_abs2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>Neurocognitive and psychosocial function was examined in 100 euthymic patients with BD (50 BD-P, 50 BD-NP), 50 stabilized patients with schizophrenia (SZ), and 51 healthy controls (HC) at baseline (T1), and after a 5-year follow-up (T2).<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800009147_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>The course of both neurocognitive performance and functional outcome of patients with SZ and BD (BD-P and BD-NP) is stable. The profile of neurocognitive impairment of patients with SZ or BD (BD-P and BD-NP), is similar, with only quantitative differences circumscribed to certain domains, such as working memory. The subgroup of patients with BD-NP does not show functional deterioration.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800009147_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>We have not found evidence of progression in the neurocognitive or psychosocial impairment in any of the three groups of patients, although it cannot be dismissed the possibility of a subset of patients with a progressive course. Other longitudinal studies with larger samples and longer duration are necessary to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2018.11.008","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T21:13:22Z","timestamp":1543353202000},"page":"60-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Neurocognition and functional outcome in patients with psychotic, non-psychotic bipolar I disorder, and schizophrenia. 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