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Reviews of pharmacological interventions remain descriptive or compare only one compound with several other compounds. The goal of this study is to compute a systematic review and meta-analysis of the effect on restoring calmness after a pharmacological intervention, so a more precise recommendation is possible.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800009305_abs2\" sec-type=\"methods\"><jats:title>Method:<\/jats:title><jats:p>A search in Pubmed and Embase was done to isolate RCT\u2019s considering pharmacological interventions in acute agitation. The outcome is reaching calmness within maximum of 2 h, assessed by the psychometric scales of PANSS-EC, CGI or ACES. Also the percentages of adverse effects was assessed.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800009305_abs3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Fifty-three papers were included for a systematic review and meta-analysis. Most frequent studied drug is olanzapine. Changes on PANNS-EC and ACES at 2 h showed the strongest changes for haloperidol plus promethazine, risperidon, olanzapine, droperidol and aripiprazole. However, incomplete data showed that the effect of risperidon is overestimated. Adverse effects are most prominent for haloperidol and haloperidol plus lorazepam.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933800009305_abs4\" sec-type=\"other\"><jats:title>Conclusion:<\/jats:title><jats:p>Olanzapine, haloperidol plus promethazine or droperidol are most effective and safe for use as rapid tranquilisation. Midazolam sedates most quickly. 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