{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:56:05Z","timestamp":1789149365520,"version":"build-2803163510"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":214,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conseller\u00eda de Educaci\u00f3n","award":["PROMETEO\/2016\/082"],"award-info":[{"award-number":["PROMETEO\/2016\/082"]}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"crossref","award":["ISCiii PI17\/00402"],"award-info":[{"award-number":["ISCiii PI17\/00402"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S092493380000273X_abst0005\" sec-type=\"other\"><jats:title>Background:<\/jats:title><jats:p>Little is known about changes in brain functioning after first-episode psychosis (FEP). Such knowledge is important for predicting the course of disease and adapting interventions. Functional magnetic resonance imaging has become a promising tool for exploring brain function at the time of symptom onset and at follow-up.<\/jats:p><\/jats:sec><jats:sec id=\"S092493380000273X_abst0010\" sec-type=\"methods\"><jats:title>Method:<\/jats:title><jats:p>A systematic review of longitudinal fMRI studies with FEP patients according to PRISMA guidelines. Resting-state and task-activated studies were considered together.<\/jats:p><\/jats:sec><jats:sec id=\"S092493380000273X_abst0015\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>Eleven studies were included. These reported on a total of 236 FEP patients were evaluated by two fMRI scans and clinical assessments. Five studies found hypoactivation at baseline in prefrontal cortex areas, two studies found hypoactivation in the amygdala and hippocampus, and three others found hypoactivation in the basal ganglia. Other hypoactivated areas were the anterior cingulate cortex, thalamus and posterior cingulate cortex. Ten out of eleven studies reported (partial) normalization by increased activation after antipsychotic treatment. A minority of studies observed hyperactivation at baseline.<\/jats:p><\/jats:sec><jats:sec id=\"S092493380000273X_abst0020\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>This review of longitudinal FEP samples studies reveals a pattern of predominantly hypoactivation in several brain areas at baseline that may normalize to a certain extent after treatment. The results should be interpreted with caution given the small number of studies and their methodological and clinical heterogeneity.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.eurpsy.2019.04.009","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T12:52:25Z","timestamp":1557319945000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Longitudinal studies of functional magnetic resonance imaging in first-episode psychosis: A systematic review"],"prefix":"10.1017","volume":"59","author":[{"given":"Carlos","family":"Gonz\u00e1lez-Vivas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Soldevila-Mat\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Sparano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graci\u00e1n","family":"Garc\u00eda-Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Mart\u00ed-Bonmat\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicto","family":"Crespo-Facorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Sanjuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"S092493380000273X_bib0195","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.12.008"},{"key":"S092493380000273X_bib0045","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.157.1.16"},{"key":"S092493380000273X_bib0255","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.01.047"},{"key":"S092493380000273X_bib0190","doi-asserted-by":"publisher","DOI":"10.1038\/srep34287"},{"key":"S092493380000273X_bib0115","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.12.2322"},{"key":"S092493380000273X_bib0245","doi-asserted-by":"publisher","DOI":"10.1177\/1971400917697342"},{"key":"S092493380000273X_bib0060","unstructured":"[12] Tarcijonas G , Sarpal DK , Neuroimaging markers of antipsychotic treatment response in schizophrenia: an overview of magnetic resonance imaging studies. 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