{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:42:24Z","timestamp":1789494144942,"version":"build-2803163510"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":153,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933800000031_abs1\" sec-type=\"other\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although pharmacogenetics for major depressive disorder (MDD) is gaining momentum, the role of genetics in differences in response to antidepressant treatment is controversial, as they depend on multifactorial and polygenic phenotypes. Previous studies focused on the genes of the serotonergic system, leaving apart other pathological factors such as the inflammatory pathway. The main objective of the study was to assess whether treatment response might be associated with specific inflammation-related genetic variants or their methylation status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800000031_abs2\" sec-type=\"methods\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      41 SNPs in 8 inflammatory genes: interleukin (\n                      <jats:italic>IL) 1-\u03b2<\/jats:italic>\n                      ,\n                      <jats:italic>IL2<\/jats:italic>\n                      ,\n                      <jats:italic>IL6<\/jats:italic>\n                      ,\n                      <jats:italic>IL6R<\/jats:italic>\n                      ,\n                      <jats:italic>IL10<\/jats:italic>\n                      ,\n                      <jats:italic>IL18<\/jats:italic>\n                      , tumor necrosis factor (\n                      <jats:italic>TNF<\/jats:italic>\n                      )\n                      <jats:italic>-\u03b1<\/jats:italic>\n                      and interferon (\n                      <jats:italic>IFN<\/jats:italic>\n                      )\n                      <jats:italic>-\u03b3<\/jats:italic>\n                      were genotyped in 153 patients with MDD, who were evaluated with the Mausdley Staging Method to determine treatment response profiles. Pyrosequencing reactions and methylation quantification were performed in a PyroMark Q24 in 5 selected CpG islands of\n                      <jats:italic>IL1- \u03b2<\/jats:italic>\n                      ,\n                      <jats:italic>IL6<\/jats:italic>\n                      and\n                      <jats:italic>IL6R<\/jats:italic>\n                      . Linear and logistic regression analyses were conducted, including age and gender as covariates using PLINK 1.07.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800000031_abs3\" sec-type=\"results\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Allelic distribution of IL1- \u03b2 rs1143643 was significantly associated with MSM scores (FDR corrected p = 0.04). Allelic distribution of IL6R rs57569414 showed a trend towards significance with MSM scores (p = 0.002; FDR corrected p = 0.07). Haplotype analyses showed associations between allelic combinations of IL1-\u03b2 and IL10 with treatment response (FDR corrected p &lt; 0.01). Methylation percentage of treatment responders was only higher in an IL6R CpG island (p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800000031_abs4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These exploratory findings suggest that\n                      <jats:italic>IL1-\u03b2<\/jats:italic>\n                      and, marginally,\n                      <jats:italic>IL6R<\/jats:italic>\n                      polymorphisms may affect treatment response in major depression. If confirmed, these results may account for the heterogeneous phenotypes of major depression that underlie differences in treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.eurpsy.2019.05.003","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T18:31:53Z","timestamp":1557858713000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association study of polymorphisms within inflammatory genes and methylation status in treatment response in major depression"],"prefix":"10.1017","volume":"60","author":[{"given":"Metodi","family":"Draganov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda 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