{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:40:06Z","timestamp":1788439206255,"version":"build-2803163510"},"reference-count":55,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":92,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"\u201cConseil Scientifique de la Recherche\u201d from CH le Vinatier"}],"content-domain":{"domain":["europsy-journal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Eur. psychiatr."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933800006441_abst0005\" sec-type=\"other\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Obsessive-compulsive disorder (OCD) is a severe mental disorder with\n                            poor response to the available treatments. Neuroimaging studies have\n                            identified dysfunctions within the\n                            orbito-fronto-striato-pallido-thalamic network in patients with OCD.\n                            Here, we assessed the efficacy and safety of transcranial direct current\n                            stimulation (tDCS) applied with the cathode over the orbitofrontal\n                            cortex (OFC) and the anode over the right cerebellum to decrease OCD\n                            symptoms in patients with treatment-resistant OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800006441_abst0010\" sec-type=\"methods\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a randomized sham-controlled double-blind study, 21 patients with\n                            OCD were assigned to receive ten 20-min sessions (two sessions per day)\n                            of either active (2 mA) or sham tDCS. The clinical symptoms were\n                            measured using the Yale-Brown Obsessive and Compulsive Scale (YBOCS).\n                            Acute effects on the symptoms were measured from baseline to immediately\n                            after the 10 tDCS sessions. Long-lasting effects were measured 1 and 3\n                            months after the 10th tDCS session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800006441_abst0015\" sec-type=\"results\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with the sham tDCS, active tDCS significantly decreased OCD\n                            symptoms immediately after the 10th tDCS session\n                                (F\n                      <jats:sub>(1,19)<\/jats:sub>\n                      = 5.26, p = 0.03). However, no\n                            significant differences were observed between the active and sham groups\n                            in terms of changes in YBOCS score or the number of responders one and 3\n                            months after tDCS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933800006441_abst0020\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Despite significant acute effects, tDCS with the cathode placed over\n                            the left OFC and the anode placed over the right cerebellum was not\n                            significantly effective in inducing a long-lasting reduction of symptoms\n                            in patients with treatment-resistant OCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.eurpsy.2019.08.011","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T11:42:57Z","timestamp":1568374977000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Transcranial direct current stimulation in patients with obsessive\n                        compulsive disorder: A randomized controlled trial"],"prefix":"10.1017","volume":"62","author":[{"given":"R\u00e9my","family":"Bation","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Mondino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Le Camus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Saoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Brunelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"S0924933800006441_bib0175","doi-asserted-by":"publisher","DOI":"10.1037\/t06496-000"},{"key":"S0924933800006441_bib0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.10.021"},{"key":"S0924933800006441_bib0240","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.11.001"},{"key":"S0924933800006441_bib0215","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2015.57"},{"key":"S0924933800006441_bib0210","doi-asserted-by":"publisher","DOI":"10.1002\/da.22330"},{"key":"S0924933800006441_bib0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.11.001"},{"key":"S0924933800006441_bib0030","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.7.720"},{"key":"S0924933800006441_bib0265","first-page":"631","article-title":"Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults","volume":"35","author":"Turski","year":"2017","journal-title":"Restor Neurol Neurosci"},{"key":"S0924933800006441_bib0120","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S121140"},{"key":"S0924933800006441_bib0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.12.003"},{"key":"S0924933800006441_bib0250","unstructured":"[50] FDA, Press Announcements - FDA permits marketing\n                            of transcranial magnetic stimulation for treatment of obsessive\n                            compulsive disorder [Internet], [cited 2018 Oct 18]. Available from:\n                            2018\n                            https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm617244.htm."},{"key":"S0924933800006441_bib0180","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.12.028"},{"key":"S0924933800006441_bib0185","unstructured":"[37] European Medecines Agency, Clinical\n                            investigation of medicinal products for the treatment of obsessive\n                            compulsive disorder 2005."},{"key":"S0924933800006441_bib0035","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21918"},{"key":"S0924933800006441_bib0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.012"},{"key":"S0924933800006441_bib0165","first-page":"1133","article-title":"A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation","volume":"14","author":"Brunoni","year":"2011","journal-title":"Int J Neuropsychopharmacol Off 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All rights reserved.","name":"copyright","label":"Copyright"}]}}