{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:13:13Z","timestamp":1783041193975,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.eururo.2003.11.010","type":"journal-article","created":{"date-parts":[[2003,12,3]],"date-time":"2003-12-03T11:56:08Z","timestamp":1070452568000},"page":"339-345","source":"Crossref","is-referenced-by-count":118,"title":["Long-Term Safety and Tolerability of Tadalafil in the Treatment of Erectile Dysfunction"],"prefix":"10.1016","volume":"45","author":[{"given":"F","family":"Montorsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Verheyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Meuleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-P","family":"J\u00fcnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Moncada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Valiquette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Casab\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Denne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.S","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2003.11.010_BIB1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1464-410x.1999.00142.x","article-title":"The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences","volume":"84","author":"Ayta\u00e7","year":"1999","journal-title":"BJU Int."},{"issue":"Suppl 4","key":"10.1016\/j.eururo.2003.11.010_BIB2","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1038\/sj.ijir.3900567","article-title":"The worldwide prevalence and epidemiology of erectile dysfunction","volume":"12","author":"McKinlay","year":"2000","journal-title":"Int. J. Impot. Res."},{"issue":"Suppl 3","key":"10.1016\/j.eururo.2003.11.010_BIB3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1464-4096.2001.123.x","article-title":"Current treatments and emerging therapeutic approaches in male erectile dysfunction","volume":"88","author":"Hatzichristou","year":"2001","journal-title":"BJU Int."},{"issue":"Suppl 10","key":"10.1016\/j.eururo.2003.11.010_BIB4","first-page":"S3","article-title":"Current treatment and future perspectives for erectile dysfunction","volume":"10","author":"Hatzichristou","year":"1998","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.eururo.2003.11.010_BIB5","unstructured":"Jardin A, Wagner G, Khoury S, Giuliano F, Goldstein I. editors, Recommendations of the First International Consultation on Erectile Dysfunction, cosponsored by the World Health Organization (WHO). Plymouth: Health Publications Ltd; 2000."},{"key":"10.1016\/j.eururo.2003.11.010_BIB6","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/S0022-5347(05)64442-4","article-title":"Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses","volume":"168","author":"Brock","year":"2002","journal-title":"J. Urol."},{"issue":"Suppl 5","key":"10.1016\/j.eururo.2003.11.010_BIB7","first-page":"S62","article-title":"Dose-normalized pharmacokinetics of single-dose tadalafil (IC351) in healthy volunteers","volume":"13","author":"Patterson","year":"2001","journal-title":"Int. J. Impot. Res."},{"issue":"Suppl 5","key":"10.1016\/j.eururo.2003.11.010_BIB8","first-page":"S63","article-title":"The effect of intrinsic and extrinsic factors on the pharmacokinetic properties of tadalafil (IC351)","volume":"13","author":"Patterson","year":"2001","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.eururo.2003.11.010_BIB9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0002-9149(00)00896-1","article-title":"Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton Consensus Panel","volume":"86","author":"DeBusk","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5347(17)34871-1","article-title":"Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study","volume":"151","author":"Feldman","year":"1994","journal-title":"J. Urol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB11","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0022-5347(05)67900-1","article-title":"Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts Male Aging Study","volume":"163","author":"Johannes","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0008-6363(99)00135-2","article-title":"Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease?","volume":"43","author":"Sullivan","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.eururo.2003.11.010_BIB13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0090-4295(91)80350-G","article-title":"Cigarette smoking and other vascular risk factors in vasculogenic impotence","volume":"38","author":"Shabsigh","year":"1991","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2003.11.010_BIB14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0094-0143(05)70141-5","article-title":"Oral drug therapy for erectile dysfunction","volume":"28","author":"Padma-Nathan","year":"2001","journal-title":"Urol. Clin. North Am."},{"key":"10.1016\/j.eururo.2003.11.010_BIB15","unstructured":"Summary of Product Characteristics. Levitra European Public Assessment Report (EPAR). First published March 19, 2003 at http:\/\/www.emea.eudra.org\/humandocs\/Humans\/EPAR\/levitraM.htm. Accessed May 20, 2003."},{"key":"10.1016\/j.eururo.2003.11.010_BIB16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0735-1097(98)00656-1","article-title":"ACC\/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease","volume":"33","author":"Cheitlin","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"issue":"Suppl 8A","key":"10.1016\/j.eururo.2003.11.010_BIB17","doi-asserted-by":"crossref","first-page":"37M","DOI":"10.1016\/S0002-9149(03)00074-2","article-title":"Cardiovascular effects of tadalafil","volume":"92","author":"Kloner","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1742-1241.2001.tb10992.x","article-title":"Three-year update of sildenafil citrate (Viagra\u00ae) efficacy and safety","volume":"55","author":"Sadovsky","year":"2001","journal-title":"Int. J. Clin. Pract."},{"issue":"Suppl A","key":"10.1016\/j.eururo.2003.11.010_BIB19","first-page":"299A","article-title":"Sildenafil prescription-event monitoring study: no evidence of an increase in cardiovascular outcomes among 5,000 men prescribed sildenafil in general practice in England","volume":"17","author":"Shakir","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/archinte.162.12.1349","article-title":"Sildenafil for male erectile dysfunction: a systematic review and meta-analysis","volume":"162","author":"Fink","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.eururo.2003.11.010_BIB21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/sj.ijir.3900354","article-title":"Clinical safety of oral sildenafil citrate (VIAGRA\u2122) in the treatment of erectile dysfunction","volume":"10","author":"Morales","year":"1998","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.eururo.2003.11.010_BIB22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/j.1939-4640.2002.tb02332.x","article-title":"Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial","volume":"23","author":"Hellstrom","year":"2002","journal-title":"J. Androl."},{"key":"10.1016\/j.eururo.2003.11.010_BIB23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/sj.ijir.3900713","article-title":"the Vardenafil Study Group. The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial","volume":"13","author":"Porst","year":"2001","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.eururo.2003.11.010_BIB24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-2999(98)00346-X","article-title":"Effect of a GMP-specific phosphodiesterase inhibitor on retinal function","volume":"352","author":"Estrade","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.eururo.2003.11.010_BIB25","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1038\/sj.ijir.3900465","article-title":"Sildenafil causes a dose- and time-dependent downregulation of phosphodiesterase type 6 expression in the rat retina","volume":"11","author":"Gonzalez","year":"1999","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.eururo.2003.11.010_BIB26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0002-9394(01)01052-2","article-title":"Acute effects of sildenafil on electroretinogram and multifocal electroretinogram","volume":"132","author":"Luu","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00041327-200020040-00001","article-title":"Acute effects of sildenafil (Viagra) on blue-on-yellow and white-on-white Humphrey perimetry","volume":"20","author":"McCulley","year":"2000","journal-title":"J. Neuroophthalmol."},{"key":"10.1016\/j.eururo.2003.11.010_BIB28","unstructured":"Summary of Product Characteristics. Cialis European Public Assessment Report (EPAR). First published June 12, 2002 at http:\/\/www.emea.eu.int\/humandocs\/Humans\/EPAR\/cialis\/cialisM.htm. Accessed May 21, 2003."}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283803005852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283803005852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T15:31:14Z","timestamp":1704987074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283803005852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0302283803005852"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2003.11.010","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}