{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:51:08Z","timestamp":1794264668061,"version":"4.9.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.eururo.2008.08.008","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T08:33:03Z","timestamp":1218616383000},"page":"1226-1236","source":"Crossref","is-referenced-by-count":166,"title":["Upper Urinary Tract Urothelial Cell Carcinomas and Other Urological Malignancies Involved in the Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) Tumor Spectrum"],"prefix":"10.1016","volume":"54","author":[{"given":"Morgan","family":"Roupr\u00eat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Comperat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Cussenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2008.08.008_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMra012242","article-title":"Hereditary colorectal cancer","volume":"348","author":"Lynch","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eururo.2008.08.008_bib2","first-page":"1635","article-title":"The tumor spectrum in HNPCC","volume":"14","author":"Watson","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0022-5347(17)39853-1","article-title":"The Lynch syndrome II and urological malignancies","volume":"143","author":"Lynch","year":"1990","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-5347(01)62926-4","article-title":"Urinary tract cancer and hereditary nonpolyposis colorectal cancer: risks and screening options","volume":"160","author":"Sijmons","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2006.02.005","article-title":"Mechanisms of chromosome instability in cancers","volume":"59","author":"Jefford","year":"2006","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.eururo.2008.08.008_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00428-003-0922-z","article-title":"Microsatellite instability analysis and\/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer?","volume":"444","author":"Halvarsson","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.eururo.2008.08.008_bib7","first-page":"2447","article-title":"Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability","volume":"62","author":"Duval","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib8","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1086\/421332","article-title":"Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history","volume":"74","author":"Buttin","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.eururo.2008.08.008_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1464-410X.2005.05585.x","article-title":"Accuracy of the routine detection of mutation in mismatch repair genes in patients with susceptibility to hereditary upper urinary tract transitional cell carcinoma","volume":"96","author":"Roupret","year":"2005","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2008.08.008_bib10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.8484121","article-title":"Clues to the pathogenesis of familial colorectal cancer","volume":"260","author":"Aaltonen","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.eururo.2008.08.008_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.8484122","article-title":"Microsatellite instability in cancer of the proximal colon","volume":"260","author":"Thibodeau","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.eururo.2008.08.008_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1155\/2004\/159347","article-title":"Quasimonomorphic mononucleotide repeats for high-level microsatellite instability analysis","volume":"20","author":"Buhard","year":"2004","journal-title":"Dis Markers"},{"key":"10.1016\/j.eururo.2008.08.008_bib13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","article-title":"Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability","volume":"96","author":"Umar","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.eururo.2008.08.008_bib14","first-page":"1894","article-title":"The role of hMLH3 in familial colorectal cancer","volume":"63","author":"Liu","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/371075a0","article-title":"Mutations of two PMS homologues in hereditary nonpolyposis colon cancer","volume":"371","author":"Nicolaides","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.eururo.2008.08.008_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archinte.1966.03870080050009","article-title":"Hereditary factors in cancer. Study of two large midwestern kindreds","volume":"117","author":"Lynch","year":"1966","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.eururo.2008.08.008_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02053699","article-title":"The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)","volume":"34","author":"Vasen","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.eururo.2008.08.008_bib18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jmg.2007.048991","article-title":"Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)","volume":"44","author":"Vasen","year":"2007","journal-title":"J Med Genet"},{"key":"10.1016\/j.eururo.2008.08.008_bib19","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1136\/jmg.2003.017871","article-title":"Microsatellite instability as indicator of MSH2 gene mutation in patients with upper urinary tract transitional cell carcinoma","volume":"41","author":"Roupret","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.eururo.2008.08.008_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ajmg.a.20106","article-title":"Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum","volume":"121","author":"Soravia","year":"2003","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.eururo.2008.08.008_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4161\/cbt.3.10.1135","article-title":"Mismatch repair gene expression and genetic instability in testicular germ cell tumor","volume":"3","author":"Velasco","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.eururo.2008.08.008_bib22","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/S0022-5347(06)00256-4","article-title":"Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance","volume":"175","author":"Catto","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib23","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1073\/pnas.0701248104","article-title":"Aristolochic acid and the etiology of endemic (Balkan) nephropathy","volume":"104","author":"Grollman","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.eururo.2008.08.008_bib24","doi-asserted-by":"crossref","first-page":"E60","DOI":"10.5858\/2003-127-e60-HNCCSI","article-title":"Hereditary nonpolyposis colorectal cancer syndrome in a patient with urothelial carcinoma of the upper urothelial tract","volume":"127","author":"Hartmann","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.eururo.2008.08.008_bib25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0140-6736(06)69079-X","article-title":"Chinese herbal uropathy and nephropathy","volume":"368","author":"Laing","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.eururo.2008.08.008_bib26","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1572-0241.2006.00636.x","article-title":"Extracolonic cancers associated with hereditary nonpolyposis colorectal cancer in the Utah Population Database","volume":"101","author":"Maul","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.eururo.2008.08.008_bib27","first-page":"5835","article-title":"Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract","volume":"58","author":"Takahashi","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1053\/hupa.2003.22","article-title":"Urothelial carcinoma of the upper urinary tract: inverted growth pattern is predictive of microsatellite instability","volume":"34","author":"Hartmann","year":"2003","journal-title":"Hum Pathol"},{"key":"10.1016\/j.eururo.2008.08.008_bib29","first-page":"6796","article-title":"Frequent microsatellite instability in sporadic tumors of the upper urinary tract","volume":"62","author":"Hartmann","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib30","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1038\/sj.onc.1206964","article-title":"Distinct patterns of microsatellite instability are seen in tumours of the urinary tract","volume":"22","author":"Catto","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.eururo.2008.08.008_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2407-5-23","article-title":"Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma","volume":"5","author":"Ericson","year":"2005","journal-title":"BMC Cancer"},{"key":"10.1016\/j.eururo.2008.08.008_bib32","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1038\/sj.onc.1209229","article-title":"Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract","volume":"25","author":"Mongiat-Artus","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.eururo.2008.08.008_bib33","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.eururo.2006.04.010","article-title":"Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer","volume":"50","author":"Burger","year":"2006","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib34","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.juro.2007.01.030","article-title":"Behavior of urothelial carcinoma with respect to anatomical location","volume":"177","author":"Catto","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib35","first-page":"5620","article-title":"Microsatellite instability in bladder cancer","volume":"53","author":"Gonzalez-Zulueta","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib36","doi-asserted-by":"crossref","first-page":"9871","DOI":"10.1073\/pnas.91.21.9871","article-title":"Microsatellite alterations as clonal markers for the detection of human cancer","volume":"91","author":"Mao","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.eururo.2008.08.008_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0090-4295(99)00399-4","article-title":"Absence of microsatellite instability in transitional cell carcinoma of the bladder","volume":"55","author":"Bonnal","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2008.08.008_bib38","first-page":"229","article-title":"Chromosome 3 allelic losses and microsatellite alterations in transitional cell carcinoma of the urinary bladder","volume":"149","author":"Li","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.eururo.2008.08.008_bib39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/367419b0","article-title":"Urothelial carcinogenesis","volume":"367","author":"Linnenbach","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.eururo.2008.08.008_bib40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.eururo.2005.11.024","article-title":"Infrequent microsatellite instability in urothelial cell carcinoma of the bladder in young patients","volume":"49","author":"Mongiat-Artus","year":"2006","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib41","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1464-410X.2006.06723.x","article-title":"Clinically localised prostate cancer is microsatellite stable","volume":"99","author":"Azzouzi","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2008.08.008_bib42","first-page":"1033","article-title":"Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer","volume":"22","author":"Chen","year":"2003","journal-title":"Int J Oncol"},{"key":"10.1016\/j.eururo.2008.08.008_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/sj.bjc.6602311","article-title":"Clinical relevance of genetic instability in prostatic cells obtained by prostatic massage in early prostate cancer","volume":"92","author":"Thuret","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.eururo.2008.08.008_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.eururo.2005.09.024","article-title":"Impact of race, age, income, and residence on prostate cancer knowledge, screening behavior, and health maintenance in siblings of patients with prostate cancer","volume":"50","author":"Pruthi","year":"2006","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib45","first-page":"4112","article-title":"Defects of DNA mismatch repair in human prostate cancer","volume":"61","author":"Chen","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib46","first-page":"362","article-title":"Clinicopathologic implications of hMSH2 gene expression and microsatellite instability in prostate cancer","volume":"1","author":"Velasco","year":"2002","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.eururo.2008.08.008_bib47","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00109-006-0074-0","article-title":"Elevated microsatellite alterations at selected tetranucleotides (EMAST) and mismatch repair gene expression in prostate cancer","volume":"84","author":"Burger","year":"2006","journal-title":"J Mol Med"},{"key":"10.1016\/j.eururo.2008.08.008_bib48","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0022-5347(05)67115-7","article-title":"The mismatch repair gene hMSH2 is mutated in the prostate cancer cell line LNCaP","volume":"164","author":"Leach","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2008.08.008_bib49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0027-5107(02)00072-6","article-title":"Mosaic AZF deletions and susceptibility to testicular tumors","volume":"503","author":"Bianchi","year":"2002","journal-title":"Mutat Res"},{"key":"10.1016\/j.eururo.2008.08.008_bib50","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0016-5085(99)70510-X","article-title":"New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC","volume":"116","author":"Vasen","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.eururo.2008.08.008_bib51","first-page":"391","article-title":"The role of clinical criteria, genetic and epigenetic alterations in Lynch-syndrome diagnosis","volume":"54","author":"Alemayehu","year":"2007","journal-title":"Neoplasma"},{"key":"10.1016\/j.eururo.2008.08.008_bib52","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1007\/s10350-007-9071-9","article-title":"Identification and classification of hereditary nonpolyposis colorectal cancer (Lynch syndrome): adapting old concepts to recent advancements. Report from the italian association for the study of hereditary colorectal tumors consensus group","volume":"50","author":"Ponz de Leon","year":"2007","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.eururo.2008.08.008_bib53","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1200\/JCO.2006.10.3119","article-title":"Who should be sent for genetic testing in hereditary colorectal cancer syndromes?","volume":"25","author":"Lynch","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.eururo.2008.08.008_bib54","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/1097-0142(20010215)91:4<625::AID-CNCR1044>3.0.CO;2-4","article-title":"Family information service and hereditary cancer","volume":"91","author":"Lynch","year":"2001","journal-title":"Cancer"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283808009482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283808009482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T20:35:27Z","timestamp":1631651727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283808009482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0302283808009482"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2008.08.008","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}