{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:47:39Z","timestamp":1772120859666,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.eururo.2009.09.023","type":"journal-article","created":{"date-parts":[[2009,9,12]],"date-time":"2009-09-12T04:26:56Z","timestamp":1252729616000},"page":"879-883","source":"Crossref","is-referenced-by-count":11,"title":["In the Human Urothelium and Suburothelium, Intradetrusor Botulinum Neurotoxin Type A Does Not Induce Apoptosis: Preliminary Results"],"prefix":"10.1016","volume":"57","author":[{"given":"Thomas M.","family":"Kessler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalesh N.","family":"Panicker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohier","family":"Elneil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare J.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Roosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2009.09.023_bib1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0022-5347(05)67283-7","article-title":"Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results","volume":"164","author":"Schurch","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib2","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1097\/01.ju.0000127725.48479.89","article-title":"Emerging role of botulinum toxin in the management of voiding dysfunction","volume":"171","author":"Smith","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/ana.21209","article-title":"Botulinum injections for the treatment of bladder symptoms of multiple sclerosis","volume":"62","author":"Kalsi","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.eururo.2009.09.023_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.eururo.2007.10.013","article-title":"Botulinum toxin A (Botox\u00ae) intradetrusor injections in adults with neurogenic detrusor overactivity\/neurogenic overactive bladder: a systematic literature review","volume":"53","author":"Karsenty","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/01.ju.0000162035.73977.1c","article-title":"Botulinum toxin type a is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study","volume":"174","author":"Schurch","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/00365590601068835","article-title":"Efficacy and impact of botulinum toxin A on quality of life in patients with neurogenic detrusor overactivity: a randomised, placebo-controlled, double-blind study","volume":"41","author":"Ehren","year":"2007","journal-title":"Scand J Urol Nephrol"},{"key":"10.1016\/j.eururo.2009.09.023_bib7","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.eururo.2005.12.010","article-title":"Proposed mechanism for the efficacy of injected botulinum toxin in the treatment of human detrusor overactivity","volume":"49","author":"Apostolidis","year":"2006","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0090-4295(03)00477-1","article-title":"Relief by botulinum toxin of voiding dysfunction due to benign prostatic hyperplasia: results of a randomized, placebo-controlled study","volume":"62","author":"Maria","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2009.09.023_bib9","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.urology.2004.10.077","article-title":"Prostate botulinum A toxin injection\u2014an alternative treatment for benign prostatic obstruction in poor surgical candidates","volume":"65","author":"Kuo","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2009.09.023_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.eururo.2007.08.050","article-title":"Intraprostatic botulinum toxin type A injection in patients unfit for surgery presenting with refractory urinary retention and benign prostatic enlargement. Effect on prostate volume and micturition resumption","volume":"53","author":"Silva","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.eururo.2008.07.003","article-title":"Mechanisms of prostate atrophy after glandular botulinum neurotoxin type A injection: an experimental study in the rat","volume":"56","author":"Silva","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.ju.0000169481.42259.54","article-title":"Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity","volume":"174","author":"Apostolidis","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib13","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2004.07.011","article-title":"Lack of ultrastructural detrusor changes following endoscopic injection of botulinum toxin type A in overactive neurogenic bladder","volume":"46","author":"Haferkamp","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib14","unstructured":"Watanabe T, Masago T, Miyagawa I. Does botulinum toxin-A induce apoptosis in rat detrusor muscle [abstract 24]? Abstract presented at: Annual Congress of the International Continence Society; October 20\u201324, 2008; Cairo, Egypt."},{"key":"10.1016\/j.eururo.2009.09.023_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1464-410X.2003.04312.x","article-title":"A minimally invasive technique for outpatient local anaesthetic administration of intradetrusor botulinum toxin in intractable detrusor overactivity","volume":"92","author":"Harper","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2009.09.023_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.eururo.2007.12.029","article-title":"Early effect on the overactive bladder symptoms following botulinum neurotoxin type A injections for detrusor overactivity","volume":"54","author":"Kalsi","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1464-410X.2005.05368_7.x","article-title":"A minimally invasive technique for outpatient local anaesthetic administration of intradetrusor botulinum toxin in intractable detrusor overactivity","volume":"95","author":"Schulte-Baukloh","year":"2005","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2009.09.023_bib18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.urology.2004.10.007","article-title":"Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin","volume":"65","author":"Apostolidis","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2009.09.023_bib19","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1464-410X.2007.07151.x","article-title":"Increased expression of transient receptor potential vanilloid subfamily 1 in the bladder predicts the response to intravesical instillations of resiniferatoxin in patients with refractory idiopathic detrusor overactivity","volume":"100","author":"Liu","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2009.09.023_bib20","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.eururo.2008.11.009","article-title":"Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment","volume":"55","author":"Roosen","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.juro.2009.02.148","article-title":"Cadherin-11 up-regulation in overactive bladder suburothelial myofibroblasts","volume":"182","author":"Roosen","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/j.eururo.2009.09.023_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1113\/jphysiol.2004.081083","article-title":"Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle","volume":"565","author":"Siu","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.eururo.2009.09.023_bib24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/dbio.1998.8871","article-title":"Fiber apoptosis in developing rat muscles is regulated by activity, neuregulin","volume":"196","author":"Trachtenberg","year":"1998","journal-title":"Dev Biol"},{"key":"10.1016\/j.eururo.2009.09.023_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/(SICI)1097-0045(19980915)37:1<44::AID-PROS7>3.0.CO;2-8","article-title":"Botox-induced prostatic involution","volume":"37","author":"Doggweiler","year":"1998","journal-title":"Prostate"},{"key":"10.1016\/j.eururo.2009.09.023_bib26","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0022-5347(05)00318-6","article-title":"Novel action of botulinum toxin on the stromal and epithelial components of the prostate gland","volume":"175","author":"Chuang","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2009.09.023_bib27","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/000348940111001110","article-title":"Botulinum toxin type A induces apoptosis in nasal glands of guinea pigs","volume":"110","author":"Rohrbach","year":"2001","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.eururo.2009.09.023_bib28","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.eururo.2008.02.037","article-title":"Histological changes in the urothelium and suburothelium of human overactive bladder following intradetrusor injections of botulinum neurotoxin type A for the treatment of neurogenic or idiopathic detrusor overactivity","volume":"53","author":"Apostolidis","year":"2008","journal-title":"Eur Urol"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283809009518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283809009518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T08:52:18Z","timestamp":1710579138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283809009518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0302283809009518"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2009.09.023","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1718956.1228054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1718956.4096054","asserted-by":"object"}]},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}