{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:30:05Z","timestamp":1787509805380,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.eururo.2012.01.046","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T18:10:18Z","timestamp":1328119818000},"page":"1178-1184","source":"Crossref","is-referenced-by-count":76,"title":["Spread of OnabotulinumtoxinA After Bladder Injection. Experimental Study Using the Distribution of Cleaved SNAP-25 as the Marker of the Toxin Action"],"prefix":"10.1016","volume":"61","author":[{"given":"Ana","family":"Coelho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia D.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Avelino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2012.01.046_bib0005","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2011.07.001","article-title":"Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of Botox (onabotulinumtoxinA) and Dysport (abobotulinumtoxinA)","volume":"60","author":"Mangera","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0010","first-page":"829","article-title":"Use of botulinum toxin in the treatment of lower urinary tract disorders. Current status","volume":"63","author":"Mangera","year":"2010","journal-title":"Arch Esp Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1590\/S1677-55382007000200002","article-title":"Botulinum toxin injection: a review of injection principles and protocols","volume":"33","author":"Rapp","year":"2007","journal-title":"Int Braz J Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0020","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.urology.2006.08.1069","article-title":"Persistence of therapeutic effect after repeated injections of botulinum toxin type A to treat incontinence due to neurogenic detrusor overactivity","volume":"68","author":"Karsenty","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2012.01.046_bib0025","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/01.ju.0000143189.19835.f3","article-title":"Inhibitory effect of intravesically applied botulinum toxin A in chronic bladder inflammation","volume":"173","author":"Vemulakonda","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0030","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1097\/01.ju.0000137844.77524.97","article-title":"Intravesical botulinum toxin a administration produces analgesia against acetic acid induced bladder pain responses in rats","volume":"172","author":"Chuang","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0035","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/mus.880160913","article-title":"Quantifying how location and dose of botulinum toxin injections affect muscle paralysis","volume":"16","author":"Shaari","year":"1993","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.eururo.2012.01.046_bib0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1017\/S0012162203000380","article-title":"Effect of muscle activity and botulinum toxin dilution volume on muscle paralysis","volume":"45","author":"Kim","year":"2003","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00345-008-0362-0","article-title":"A morphological evaluation of botulinum neurotoxin A injections into the detrusor muscle using magnetic resonance imaging","volume":"27","author":"Mehnert","year":"2009","journal-title":"World J Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0050","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1464-410X.2007.07137.x","article-title":"Persistence of the synaptosomal-associated protein-25 cleavage product after intradetrusor botulinum toxin A injections in patients with myelomeningocele showing an inadequate response to treatment","volume":"100","author":"Schulte-Baukloh","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2012.01.046_bib0115","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.juro.2011.10.130","article-title":"Effect of onabotulinumtoxinA on intramural parasympathetic ganglia: an experimental study in the guinea-pig urinary bladder","volume":"187","author":"Coelho","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0060","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1523\/JNEUROSCI.2618-11.2011","article-title":"Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT\/A)","volume":"31","author":"Restani","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.eururo.2012.01.046_bib0065","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.eururo.2009.12.022","article-title":"Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder","volume":"57","author":"Coelho","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0070","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1002\/j.1460-2075.1993.tb06171.x","article-title":"Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1\/syntaxin","volume":"12","author":"Blasi","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/j.eururo.2012.01.046_bib0075","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-5793(93)80448-4","article-title":"Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds","volume":"335","author":"Schiavo","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.eururo.2012.01.046_bib0080","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1126\/science.1123654","article-title":"SV2 is the protein receptor for botulinum neurotoxin A","volume":"312","author":"Dong","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.eururo.2012.01.046_bib0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1569-9056(09)60199-8","article-title":"Intravesical Botox injections in children with a idiopathic overactive bladder","volume":"8","author":"Landman","year":"2009","journal-title":"Eur Urol Suppl"},{"key":"10.1016\/j.eururo.2012.01.046_bib0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11255-010-9790-z","article-title":"Intravesical instillation of botulinum toxin A: an in vivo murine study and pilot clinical trial","volume":"43","author":"Krhut","year":"2011","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0095","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.urology.2005.01.055","article-title":"In vivo effects of botulinum toxin A on visceral sensory function in chronic spinal cord-injured rats","volume":"66","author":"Khera","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2012.01.046_bib0100","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.juro.2009.03.083","article-title":"Urodynamic and immunohistochemical evaluation of intravesical botulinum toxin A delivery using liposomes","volume":"182","author":"Chuang","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0105","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncpuro1124","article-title":"Drug Insight: biological effects of botulinum toxin A in the lower urinary tract","volume":"5","author":"Chancellor","year":"2008","journal-title":"Nat Clin Pract Urol"},{"key":"10.1016\/j.eururo.2012.01.046_bib0110","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.eururo.2010.02.031","article-title":"Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome\/interstitial cystitis","volume":"58","author":"Pinto","year":"2010","journal-title":"Eur Urol"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283812001224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283812001224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T17:13:33Z","timestamp":1713460413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283812001224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0302283812001224"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2012.01.046","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}