{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:32:52Z","timestamp":1792711972070,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.eururo.2016.02.054","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T18:22:22Z","timestamp":1457202142000},"page":"668-674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Medium-term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort"],"prefix":"10.1016","volume":"70","author":[{"given":"Louise","family":"Dickinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manit","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cathcart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Charman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cornaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Hindley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Lewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"McCartan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Ogden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Persad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"van der Meulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Emberton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim U.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2016.02.054_bib0160","doi-asserted-by":"crossref","first-page":"f325","DOI":"10.1136\/bmj.f325","article-title":"Prostate cancer screening and the management of clinically localized disease","volume":"346","author":"Wilt","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.eururo.2016.02.054_bib0165","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.2009.1451","article-title":"Comparative effectiveness of minimally invasive vs open radical prostatectomy","volume":"302","author":"Hu","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.eururo.2016.02.054_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1464-410X.2010.09885.x","article-title":"Initial treatment costs of organ-confined prostate cancer: a general perspective","volume":"107","author":"Kommu","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2016.02.054_bib0175","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1200\/JCO.2010.31.1217","article-title":"Cost implications of the rapid adoption of newer technologies for treating prostate cancer","volume":"29","author":"Nguyen","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/sj.bjc.6605116","article-title":"High-intensity focused ultrasound in the treatment of primary prostate cancer: the first UK series","volume":"101","author":"Ahmed","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.eururo.2016.02.054_bib0185","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.eururo.2010.09.009","article-title":"Systematic review of the efficacy and safety of high-intensity focused ultrasound for the primary and salvage treatment of prostate cancer","volume":"58","author":"Warmuth","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0190","doi-asserted-by":"crossref","first-page":"a1655","DOI":"10.1136\/bmj.a1655","article-title":"Developing and evaluating complex interventions: the new Medical Research Council guidance","volume":"337","author":"Craig","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.eururo.2016.02.054_bib0195","doi-asserted-by":"crossref","first-page":"f3011","DOI":"10.1136\/bmj.f3011","article-title":"IDEAL framework for surgical innovation 2: observational studies in the exploration and assessment stages","volume":"346","author":"Ergina","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.eururo.2016.02.054_bib0200","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1259\/bjr\/61380797","article-title":"Prostatic cancer surveillance following whole-gland high-intensity focused ultrasound: comparison of MRI and prostate-specific antigen for detection of residual or recurrent disease","volume":"85","author":"Punwani","year":"2012","journal-title":"Br J Radiol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0205","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.juro.2011.03.147","article-title":"Characterizing clinically significant prostate cancer using template prostate mapping biopsy","volume":"186","author":"Ahmed","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0210","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2006.04.029","article-title":"Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference","volume":"65","author":"Roach","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.eururo.2016.02.054_bib0215","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1464-410X.2009.08518.x","article-title":"High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure","volume":"104","author":"Blana","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2016.02.054_bib0220","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The international index of erectile function (IIEF): a multi-dimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2016.02.054_bib0225","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/00005650-199807000-00007","article-title":"The UCLA Prostate Cancer Index: development, reliability, and validity of a health-related quality of life measure","volume":"36","author":"Litwin","year":"1998","journal-title":"Med Care"},{"key":"10.1016\/j.eururo.2016.02.054_bib0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.juro.2014.07.096","article-title":"Improved outcomes with advancements in high intensity focused ultrasound devices for the treatment of localized prostate cancer","volume":"193","author":"Uchida","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0235","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.eururo.2013.04.039","article-title":"Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: oncologic outcomes and morbidity in 1002 patients","volume":"65","author":"Crouzet","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0240","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1464-410X.2012.11715.x","article-title":"Fourteen-year oncological and functional outcomes of high-intensity focused ultrasound in localized prostate cancer","volume":"112","author":"Ganzer","year":"2013","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2016.02.054_bib0245","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1089\/end.2014.0696","article-title":"A whole of population, multi-user series of hifu for management of localised prostate cancer: outcomes and implications","volume":"29","author":"Bolton","year":"2015","journal-title":"J Endourol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0250","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1464-410X.2009.08355.x","article-title":"High-intensity focused ultrasound for localized prostate cancer: initial experience with a 2-year follow-up","volume":"104","author":"Challacombe","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2016.02.054_bib0255","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(13)70606-5","article-title":"Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study","volume":"15","author":"Nam","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0260","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJMoa1209978","article-title":"Long-term functional outcomes after treatment for localized prostate cancer","volume":"368","author":"Resnick","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eururo.2016.02.054_bib0265","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.eururo.2015.02.028","article-title":"Achieving quality assurance of prostate cancer surgery during reorganisation of cancer services","volume":"68","author":"Cathcart","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0270","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/jama.2011.1333","article-title":"Prediction of erectile function following treatment for prostate cancer","volume":"306","author":"Alemozaffar","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.eururo.2016.02.054_bib0275","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ncponc0959","article-title":"Will focal therapy become a standard of care for men with localised prostate cancer?","volume":"4","author":"Ahmed","year":"2007","journal-title":"Nat Clin Pract Oncol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0280","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/end.2009.0596","article-title":"Focal therapy in prostate cancer \u2013 report from a consensus panel","volume":"24","author":"De la Rosette","year":"2010","journal-title":"J Endourol"},{"issue":"Suppl 1","key":"10.1016\/j.eururo.2016.02.054_bib0285","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1464-410X.2011.10825.x","article-title":"Report of a consensus meeting on focal low dose rate brachytherapy for prostate cancer","volume":"109","author":"Langley","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2016.02.054_bib0290","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.juro.2010.11.079","article-title":"Focal therapy for localized prostate cancer: a phase I\/II trial","volume":"185","author":"Ahmed","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0295","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.eururo.2015.01.030","article-title":"Focal ablation targeted to the index lesion in multifocal localised prostate cancer: a prospective development study","volume":"68","author":"Ahmed","year":"2015","journal-title":"Eur Urol."},{"key":"10.1016\/j.eururo.2016.02.054_bib0300","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S1470-2045(12)70121-3","article-title":"Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study","volume":"13","author":"Ahmed","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.eururo.2016.02.054_bib0305","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cct.2013.06.005","article-title":"A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study","volume":"36","author":"Dickinson","year":"2013","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.eururo.2016.02.054_bib0310","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.juro.2013.12.036","article-title":"Morbidity associated with primary high intensity focused ultrasound and redo high intensity focused ultrasound for localised prostate cancer","volume":"191","author":"Berge","year":"2014","journal-title":"J Urol"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030228381600244X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030228381600244X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T15:27:47Z","timestamp":1536938867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030228381600244X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S030228381600244X"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2016.02.054","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medium-term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort","name":"articletitle","label":"Article Title"},{"value":"European Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eururo.2016.02.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V. on behalf of European Association of Urology.","name":"copyright","label":"Copyright"}]}}