{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:48:17Z","timestamp":1790135297988,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.eururo.2016.02.058","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T15:01:57Z","timestamp":1457362917000},"page":"283-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Expression of Inflammatory Mediators in Bladder Pain Syndrome"],"prefix":"10.1016","volume":"70","author":[{"given":"Ifeoma","family":"Offiah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Didangelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dawes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus","family":"Cartwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vik","family":"Khullar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dic","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain P.","family":"Chessell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Pallas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2016.02.058_bib0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"van de Merwe","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0155","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1067\/mob.2002.125704","article-title":"The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society","volume":"187","author":"Abrams","year":"2002","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl 5A","key":"10.1016\/j.eururo.2016.02.058_bib0160","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(99)80327-6","article-title":"Epidemiology of interstitial cystitis","volume":"49","author":"Jones","year":"1997","journal-title":"Urology"},{"issue":"Suppl 4","key":"10.1016\/j.eururo.2016.02.058_bib0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.urology.2006.03.084","article-title":"The role of the urinary epithelium in the pathogenesis of interstitial cystitis\/prostatitis\/urethritis","volume":"69","author":"Parsons","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2016.02.058_bib0170","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0022-5347(17)39611-8","article-title":"Interstitial cystitis: bladder mucosa lymphocyte immunophenotyping and peripheral blood flow cytometry analysis","volume":"144","author":"Harrington","year":"1990","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0175","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1523\/JNEUROSCI.4369-13.2014","article-title":"Large-scale chondroitin sulfate digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury","volume":"34","author":"Bartus","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.eururo.2016.02.058_bib0180","doi-asserted-by":"crossref","first-page":"11998","DOI":"10.1523\/JNEUROSCI.3877-08.2008","article-title":"Chondroitinase ABC-mediated plasticity of spinal sensory function","volume":"28","author":"Cafferty","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.eururo.2016.02.058_bib0185","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.eururo.2016.02.058_bib0190","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/1471-2164-13-296","article-title":"ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data","volume":"13","author":"Perkins","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.eururo.2016.02.058_bib0195","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/CIRCGENETICS.110.959098","article-title":"Comparative lipidomics profiling of human atherosclerotic plaques","volume":"4","author":"Stegemann","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.eururo.2016.02.058_bib0200","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.physbeh.2014.11.045","article-title":"Chronic psychological stress in high-anxiety rats induces sustained bladder hyperalgesia","volume":"139","author":"Lee","year":"2015","journal-title":"Physiol Behav"},{"key":"10.1016\/j.eururo.2016.02.058_bib0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neuroscience Methods"},{"key":"10.1016\/j.eururo.2016.02.058_bib0210","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1182\/blood-2010-01-264390","article-title":"The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses","volume":"116","author":"Comerford","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.eururo.2016.02.058_bib0215","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(87)91065-7","article-title":"A model for the study of visceral pain states: chronic inflammation of the chronic decerebrate rat urinary bladder by irritant chemicals","volume":"28","author":"McMahon","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.eururo.2016.02.058_bib0220","doi-asserted-by":"crossref","first-page":"865463","DOI":"10.1155\/2014\/865463","article-title":"Evidence for bladder urothelial pathophysiology in functional bladder disorders","volume":"2014","author":"Keay","year":"2014","journal-title":"Biomed Res Int"},{"issue":"Suppl 1","key":"10.1016\/j.eururo.2016.02.058_bib0225","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/iju.12370","article-title":"Inflammation characteristics in bladder pain syndrome ESSIC type 3C\/classic interstitial cystitis","volume":"21","author":"Logadottir","year":"2014","journal-title":"Int J Urol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0230","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.juro.2014.05.047","article-title":"Correlation of gene expression with bladder capacity in interstitial cystitis\/bladder pain syndrome","volume":"192","author":"Colaco","year":"2014","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0235","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00192-013-2112-0","article-title":"Local immune response in bladder pain syndrome\/interstitial cystitis ESSIC type 3C","volume":"24","author":"Gamper","year":"2013","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2016.02.058_bib0240","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1464-410x.2001.02179.x","article-title":"A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction","volume":"87","author":"O\u2019Reilly","year":"2001","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2016.02.058_bib0245","doi-asserted-by":"crossref","first-page":"e76779","DOI":"10.1371\/journal.pone.0076779","article-title":"Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis\/bladder pain syndrome","volume":"8","author":"Jiang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2016.02.058_bib0250","doi-asserted-by":"crossref","first-page":"e44687","DOI":"10.1371\/journal.pone.0044687","article-title":"Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2016.02.058_bib0255","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2174\/09298665113206660115","article-title":"An overview on keratinocyte growth factor: from the molecular properties to clinical applications","volume":"21","author":"Yen","year":"2014","journal-title":"Protein Pept Lett"},{"key":"10.1016\/j.eururo.2016.02.058_bib0260","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1200\/JCO.2003.10.079","article-title":"Randomized phase I trial of recombinant human keratinocyte growth factor plus chemotherapy: potential role as mucosal protectant","volume":"21","author":"Meropol","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0265","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1200\/JCO.2005.04.1152","article-title":"Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy","volume":"24","author":"Rosen","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0270","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/art.30232","article-title":"Characterization of CCL19 and CCL21 in rheumatoid arthritis","volume":"63","author":"Pickens","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.eururo.2016.02.058_bib0275","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/emboj.2011.89","article-title":"Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development","volume":"30","author":"Biber","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.eururo.2016.02.058_bib0280","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0016-5085(03)01194-6","article-title":"The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C","volume":"125","author":"Bonacchi","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.eururo.2016.02.058_bib0285","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.2353\/ajpath.2007.060649","article-title":"Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice","volume":"170","author":"Pierce","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.eururo.2016.02.058_bib0290","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/eji.201445015","article-title":"CCRL1\/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice","volume":"45","author":"Lucas","year":"2015","journal-title":"Eur J Immunol"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283816002487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283816002487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T08:55:52Z","timestamp":1567673752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283816002487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0302283816002487"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2016.02.058","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Expression of Inflammatory Mediators in Bladder Pain Syndrome","name":"articletitle","label":"Article Title"},{"value":"European Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eururo.2016.02.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association of Urology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}