{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:37:34Z","timestamp":1793407054686,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.eururo.2016.07.033","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T19:32:45Z","timestamp":1470339165000},"page":"776-787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response"],"prefix":"10.1016","volume":"71","author":[{"given":"Erik Bovinder","family":"Ylitalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Thysell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Jernberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lundholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sead","family":"Crnalic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Egevad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Widmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2016.07.033_bib0185","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1200\/JCO.2011.39.1300","article-title":"Molecular states underlying androgen receptor activation: a framework for therapeutics targeting androgen signaling in prostate cancer","volume":"30","author":"Nelson","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1756287213509677","article-title":"Sequential use of novel therapeutics in advanced prostate cancer following docetaxel chemotherapy","volume":"6","author":"Omlin","year":"2014","journal-title":"Ther Adv Urol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0195","doi-asserted-by":"crossref","first-page":"e19059","DOI":"10.1371\/journal.pone.0019059","article-title":"Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival","volume":"6","author":"H\u00f6rnberg","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2016.07.033_bib0200","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMoa1315815","article-title":"AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer","volume":"371","author":"Antonarakis","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eururo.2016.07.033_bib0205","doi-asserted-by":"crossref","first-page":"e77407","DOI":"10.1371\/journal.pone.0077407","article-title":"Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants","volume":"8","author":"Jernberg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2016.07.033_bib0210","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1677\/ERC-10-0059","article-title":"Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients","volume":"17","author":"Crnalic","year":"2010","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.eururo.2016.07.033_bib0215","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1158\/1078-0432.CCR-09-0103","article-title":"Low levels of phosphorylated epidermal growth factor receptor in nonmalignant and malignant prostate tissue predict favorable outcome in prostate cancer patients","volume":"16","author":"Hammarsten","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.eururo.2016.07.033_bib0220","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00216-004-2783-y","article-title":"Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm)","volume":"380","author":"Eriksson","year":"2004","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.eururo.2016.07.033_bib0225","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0090-4295(99)80301-X","article-title":"Loss of HLA class I expression in prostate cancer: implications for immunotherapy","volume":"46","author":"Blades","year":"1995","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2016.07.033_bib0230","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00262-009-0769-5","article-title":"Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer","volume":"59","author":"Seliger","year":"2010","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.eururo.2016.07.033_bib0235","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.juro.2007.03.109","article-title":"Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition","volume":"178","author":"Kitamura","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0240","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ccr.2012.07.016","article-title":"Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells","volume":"22","author":"Domingo-Domenech","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.eururo.2016.07.033_bib0245","doi-asserted-by":"crossref","first-page":"e14175","DOI":"10.1371\/journal.pone.0014175","article-title":"Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol","volume":"5","author":"Thysell","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2016.07.033_bib0250","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.eururo.2015.10.053","article-title":"The proteome of primary prostate cancer","volume":"69","author":"Iglesias-Gato","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0255","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrd4591","article-title":"Combination cancer immunotherapy and new immunomodulatory targets","volume":"14","author":"Mahoney","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.eururo.2016.07.033_bib0260","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1479-5876-11-247","article-title":"HLA-dependent tumour development: a role for tumour associate macrophages?","volume":"11","author":"Marchesi","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.eururo.2016.07.033_bib0265","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fonc.2015.00128","article-title":"Immune Infiltration and Prostate Cancer","volume":"5","author":"Strasner","year":"2015","journal-title":"Front Oncol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0270","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/modpathol.2012.164","article-title":"CD4 helper T cells, CD8 cytotoxic T cells, and FOXP3+ regulatory T cells with respect to lethal prostate cancer","volume":"26","author":"Davidsson","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0275","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.ejca.2012.11.035","article-title":"High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer","volume":"49","author":"Flammiger","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.eururo.2016.07.033_bib0280","doi-asserted-by":"crossref","first-page":"486798","DOI":"10.1155\/2014\/486798","article-title":"The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy","volume":"2014","author":"Lanciotti","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.eururo.2016.07.033_bib0285","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.ejca.2014.03.278","article-title":"High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome","volume":"50","author":"Tidehag","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.eururo.2016.07.033_bib0290","doi-asserted-by":"crossref","first-page":"15651","DOI":"10.1038\/srep15651","article-title":"Secreted factors from colorectal and prostate cancer cells skew the immune response in opposite directions","volume":"5","author":"Lundholm","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.eururo.2016.07.033_bib0295","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00262-014-1591-2","article-title":"Correlation between frequencies of blood monocytic myeloid-derived suppressor cells, regulatory T cells and negative prognostic markers in patients with castration-resistant metastatic prostate cancer","volume":"63","author":"Idorn","year":"2014","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.eururo.2016.07.033_bib0300","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12916-015-0442-0","article-title":"A robust blood gene expression-based prognostic model for castration-resistant prostate cancer","volume":"13","author":"Wang","year":"2015","journal-title":"BMC Med"},{"key":"10.1016\/j.eururo.2016.07.033_bib0305","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.urology.2014.12.029","article-title":"Current and emerging immunotherapies for castration-resistant prostate cancer","volume":"85","author":"Saad","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2016.07.033_bib0310","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/ng.3419","article-title":"The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis","volume":"47","author":"Pomerantz","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.eururo.2016.07.033_bib0315","doi-asserted-by":"crossref","first-page":"e1004656","DOI":"10.1371\/journal.pgen.1004656","article-title":"SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene","volume":"10","author":"Cheng","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.eururo.2016.07.033_bib0320","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3892\/ijo.2014.2485","article-title":"HOXB13 regulates the prostate-derived Ets factor: implications for prostate cancer cell invasion","volume":"45","author":"Kim","year":"2014","journal-title":"Int J Oncol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0325","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad6352","article-title":"The tumor microenvironment and immunoscore are critical determinants of dissemination to distant metastasis","volume":"8","author":"Mlecnik","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.eururo.2016.07.033_bib0330","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.semcancer.2012.03.003","article-title":"The role of classical and non-classical HLA class I antigens in human tumors","volume":"22","author":"Bukur","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0335","doi-asserted-by":"crossref","first-page":"26562","DOI":"10.1074\/jbc.M115.676130","article-title":"Multiple structural and epigenetic defects in the human leukocyte antigen class I antigen presentation pathway in a recurrent metastatic melanoma following immunotherapy","volume":"290","author":"Chang","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.eururo.2016.07.033_bib0340","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1158\/1078-0432.CCR-06-3091","article-title":"Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2\u2032-deoxycytidine in cutaneous melanoma: immunotherapeutic implications","volume":"13","author":"Fonsatti","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.eururo.2016.07.033_bib0345","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jim.2009.06.004","article-title":"Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients","volume":"348","author":"Gannon","year":"2009","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.eururo.2016.07.033_bib0350","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1158\/1078-0432.CCR-10-2804","article-title":"Androgen deprivation boosts prostatic infiltration of cytotoxic and regulatory T lymphocytes and has no effect on disease-free survival in prostate cancer patients","volume":"17","author":"Sorrentino","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.eururo.2016.07.033_bib0355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cellimm.2015.02.004","article-title":"Suppressive effects of androgens on the immune system","volume":"294","author":"Trigunaite","year":"2015","journal-title":"Cell Immunol"},{"key":"10.1016\/j.eururo.2016.07.033_bib0360","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1038\/onc.2013.497","article-title":"Metastatic castration-resistant prostate cancer: new therapies, novel combination strategies and implications for immunotherapy","volume":"33","author":"Drake","year":"2014","journal-title":"Oncogene"}],"updated-by":[{"DOI":"10.1016\/j.eururo.2017.07.043","type":"addendum","label":"Addendum","source":"publisher","updated":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000}}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283816304389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283816304389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T01:06:53Z","timestamp":1568250413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283816304389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0302283816304389"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2016.07.033","relation":{"addendum":[{"id-type":"doi","id":"10.1016\/j.eururo.2017.07.043","asserted-by":"object"}]},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response","name":"articletitle","label":"Article Title"},{"value":"European Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eururo.2016.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association of Urology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}