{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:07:59Z","timestamp":1789891679375,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.eururo.2017.02.038","type":"journal-article","created":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T00:45:10Z","timestamp":1489884310000},"page":"524-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer"],"prefix":"10.1016","volume":"73","author":[{"given":"Fan","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Takhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varune Rohan","family":"Ramnarine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav V.","family":"Volik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendric","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Haegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Brahmbhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Erho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Gout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jeffrey","family":"Karnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Den","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shancheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Cenk","family":"Sahinalp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Gleave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elai","family":"Davicioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2017.02.038_bib0155","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/cas.12460","article-title":"Low-grade prostate cancer diverges early from high grade and metastatic disease","volume":"105","author":"VanderWeele","year":"2014","journal-title":"Cancer Sci"},{"key":"10.1016\/j.eururo.2017.02.038_bib0160","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/cncr.25751","article-title":"Overtreatment of men with low-risk prostate cancer and significant comorbidity","volume":"117","author":"Daskivich","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.eururo.2017.02.038_bib0165","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/jnci\/djp278","article-title":"Prostate cancer diagnosis and treatment after the introduction of prostate-specific antigen screening: 1986-2005","volume":"101","author":"Welch","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.eururo.2017.02.038_bib0170","doi-asserted-by":"crossref","first-page":"127rv3","DOI":"10.1126\/scitranslmed.3003180","article-title":"Beyond PSA: the next generation of prostate cancer biomarkers","volume":"4","author":"Prensner","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.eururo.2017.02.038_bib0175","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S1470-2045(14)71021-6","article-title":"Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study","volume":"15","author":"Lalonde","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0180","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1158\/1078-0432.CCR-09-0948","article-title":"A group of genome-based biomarkers that add to a Kattan nomogram for predicting progression in men with high-risk prostate cancer","volume":"16","author":"Paris","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.eururo.2017.02.038_bib0185","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"Ramaswamy","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.eururo.2017.02.038_bib0190","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S1470-2045(12)70263-2","article-title":"A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study","volume":"13","author":"Ross","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0195","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.eururo.2014.05.004","article-title":"A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling","volume":"66","author":"Klein","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0200","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ygeno.2007.02.005","article-title":"Expression signatures that correlated with Gleason score and relapse in prostate cancer","volume":"89","author":"Bibikova","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.eururo.2017.02.038_bib0205","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1200\/JCO.2010.32.6421","article-title":"mRNA expression signature of Gleason grade predicts lethal prostate cancer","volume":"29","author":"Penney","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0210","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1073\/pnas.1215870110","article-title":"Development and validation of a 32-gene prognostic index for prostate cancer progression","volume":"110","author":"Wu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.eururo.2017.02.038_bib0215","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2164\/jandrol.109.008748","article-title":"Analysis of differentially expressed genes in LNCaP prostate cancer progression model","volume":"32","author":"Xie","year":"2011","journal-title":"J Androl"},{"key":"10.1016\/j.eururo.2017.02.038_bib0220","doi-asserted-by":"crossref","first-page":"e66855","DOI":"10.1371\/journal.pone.0066855","article-title":"Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy","volume":"8","author":"Erho","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2017.02.038_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0426-y","article-title":"Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer","volume":"15","author":"Wyatt","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0230","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/(SICI)1096-9896(199611)180:3<295::AID-PATH663>3.0.CO;2-W","article-title":"Histological grade heterogeneity in multifocal prostate cancer. Biological and clinical implications","volume":"180","author":"Ruijter","year":"1996","journal-title":"J Pathol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0235","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1158\/0008-5472.CAN-13-2921-T","article-title":"High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development","volume":"74","author":"Lin","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.eururo.2017.02.038_bib0240","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/nm.2454","article-title":"Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes","volume":"17","author":"DeRose","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.eururo.2017.02.038_bib0245","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1158\/1078-0432.CCR-06-0252","article-title":"Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression\u2013related changes","volume":"12","author":"Cutz","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.eururo.2017.02.038_bib0250","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ajpath.2015.01.016","article-title":"Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements","volume":"185","author":"Delitto","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0255","doi-asserted-by":"crossref","first-page":"e2318","DOI":"10.1371\/journal.pone.0002318","article-title":"A tissue biomarker panel predicting systemic progression after PSA recurrence post-definitive prostate cancer therapy","volume":"3","author":"Nakagawa","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.eururo.2017.02.038_bib0260","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.juro.2013.06.017","article-title":"Validation of a genomic classifier that predicts metastasis following radical prostatectomy in an at risk patient population","volume":"190","author":"Karnes","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0265","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.eururo.2014.10.036","article-title":"A genomic classifier improves prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy","volume":"67","author":"Klein","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.eururo.2015.05.042","article-title":"Tissue-based genomics augments post-prostatectomy risk stratification in a natural history cohort of intermediate-and high-risk men","volume":"69","author":"Ross","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0275","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative genomic profiling of human prostate cancer","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.eururo.2017.02.038_bib0280","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ijc.28025","article-title":"Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer","volume":"133","author":"Boormans","year":"2013","journal-title":"Int J Cancer"},{"key":"10.1016\/j.eururo.2017.02.038_bib0285","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/01.ju.0000155535.25971.de","article-title":"Ability of 2 pretreatment risk assessment methods to predict prostate cancer recurrence after radical prostatectomy: data from CaPSURE","volume":"173","author":"Mitchell","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2017.02.038_bib0290","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jama.280.11.969","article-title":"Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer","volume":"280","author":"D\u2019Amico","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.eururo.2017.02.038_bib0295","doi-asserted-by":"crossref","first-page":"327ra26","DOI":"10.1126\/scitranslmed.aad6352","article-title":"The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis","volume":"8","author":"Mlecnik","year":"2016","journal-title":"Science Transl Med"},{"key":"10.1016\/j.eururo.2017.02.038_bib0300","doi-asserted-by":"crossref","first-page":"e86824","DOI":"10.1371\/journal.pone.0086824","article-title":"TMPRSS2-ERG expression predicts prostate cancer survival and associates with stromal biomarkers","volume":"9","author":"H\u00e4ggl\u00f6f","year":"2014","journal-title":"PLoS One"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283817301665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283817301665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T10:17:56Z","timestamp":1529662676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283817301665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0302283817301665"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2017.02.038","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer","name":"articletitle","label":"Article Title"},{"value":"European Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eururo.2017.02.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}