{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:35Z","timestamp":1791312095710,"version":"4.3.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.eururo.2018.06.022","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T10:57:50Z","timestamp":1531133870000},"page":"722-728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging"],"prefix":"10.1016","volume":"74","author":[{"given":"Henrik","family":"Gr\u00f6nberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Picker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Aly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"J\u00e4derling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Adolfsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Landquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Skaaheim","family":"Haug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Str\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2018.06.022_bib0145","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/S0140-6736(14)60525-0","article-title":"Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up","volume":"384","author":"Schr\u00f6der","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.eururo.2018.06.022_bib0150","doi-asserted-by":"crossref","first-page":"dju007-7","DOI":"10.1093\/jnci\/dju007","article-title":"Prostate cancer mortality in areas with high and low prostate cancer incidence","volume":"106","author":"Stattin","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.eururo.2018.06.022_bib0155","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.eururo.2018.06.022_bib0160","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1056\/NEJMoa031918","article-title":"Prevalence of prostate cancer among men with a prostate-specific antigen level","volume":"350","author":"Thompson","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eururo.2018.06.022_bib0165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.eururo.2018.06.022_bib0170","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.eururo.2012.01.050","article-title":"Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades","volume":"61","author":"Epstein","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0175","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.eururo.2013.01.011","article-title":"Serum isoform [-2]proPSA derivatives significantly improve prediction of prostate cancer at initial biopsy in a total PSA range of 2-10 ng\/ml: a multicentric European study","volume":"63","author":"Lazzeri","year":"2013","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0180","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/bju.13676","article-title":"Prostate Health Index improves multivariable risk prediction of aggressive prostate cancer","volume":"120","author":"Loeb","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2018.06.022_bib0185","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv095","article-title":"Predicting high-grade cancer at ten-core prostate biopsy using four kallikrein markers measured in blood in the ProtecT study","volume":"107","author":"Bryant","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.eururo.2018.06.022_bib0190","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S1470-2045(15)00361-7","article-title":"Prostate cancer screening in men aged 50-69 years (STHLM3): a prospective population-based diagnostic study","volume":"16","author":"Gr\u00f6nberg","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0195","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/bju.13314","volume":"117","author":"Poyet","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2018.06.022_bib0200","doi-asserted-by":"crossref","unstructured":"Eklund M, Nordstr\u00f6m T, Aly M, et al. The Stockholm-3 (STHLM3) model can improve prostate cancer diagnostics in men aged 50-69 yr compared with current prostate cancer testing. Eur Urol Focus. In press. https:\/\/doi.org\/10.1016\/j.euf.2016.10.009.","DOI":"10.1016\/j.euf.2016.10.009"},{"key":"10.1016\/j.eururo.2018.06.022_bib0205","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3322\/caac.21333","article-title":"Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer","volume":"66","author":"Turkbey","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.eururo.2018.06.022_bib0210","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/jama.2014.17942","article-title":"Comparison of MR\/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer","volume":"313","author":"Siddiqui","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.eururo.2018.06.022_bib0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.eururo.2014.03.002","article-title":"Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies","volume":"66","author":"Pokorny","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.eururo.2016.07.041","article-title":"Comparing three different techniques for magnetic resonance imaging-targeted prostate biopsies: a systematic review of in-bore versus magnetic resonance imaging-transrectal ultrasound fusion versus cognitive registration. Is there a preferred technique?","volume":"71","author":"Wegelin","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0225","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.euf.2017.01.014","article-title":"Detection of prostate cancer using a multistep approach with prostate-specific antigen, the Stockholm 3 test, and targeted biopsies: the STHLM3 MRI project","volume":"3","author":"Nordstr\u00f6m","year":"2017","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.eururo.2018.06.022_bib0230","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.eururo.2015.08.038","article-title":"Synopsis of the PI-RADS v2 guidelines for multiparametric prostate magnetic resonance imaging and recommendations for use","volume":"69","author":"Barentsz","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0235","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system","volume":"40","author":"Epstein","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0240","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.eururo.2015.12.006","article-title":"Role of magnetic resonance imaging in prostate cancer screening: a pilot study within the G\u00f6teborg randomised screening trial","volume":"70","author":"Grenabo Bergdahl","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0245","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.eururo.2017.02.026","article-title":"What is the negative predictive value of multiparametric magnetic resonance imaging in excluding prostate cancer at biopsy?. A systematic review and meta-analysis from the European Association of Urology Prostate Cancer Guidelines Panel","volume":"72","author":"Moldovan","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0250","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.eururo.2013.12.012","article-title":"Cost-effectiveness of magnetic resonance (MR) imaging and MR-guided targeted biopsy versus systematic transrectal ultrasound-guided biopsy in diagnosing prostate cancer: a modelling study from a health care perspective","volume":"66","author":"De Rooij","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2018.06.022_bib0255","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/bju.12892","article-title":"Defining the learning curve for multiparametric magnetic resonance imaging (MRI) of the prostate using MRI-transrectal ultrasonography (TRUS) fusion-guided transperineal prostate biopsies as a validation tool","volume":"117","author":"Gaziev","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2018.06.022_bib0260","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/bju.14098","article-title":"Incorporating prostate health index density, MRI, and prior negative biopsy status to improve the detection of clinically significant prostate cancer","volume":"121","author":"Druskin","year":"2018","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2018.06.022_bib0265","doi-asserted-by":"crossref","first-page":"35364","DOI":"10.1038\/srep35364","article-title":"The Prostate Health Index adds predictive value to multi-parametric MRI in detecting significant prostate cancers in a repeat biopsy population","volume":"6","author":"Gnanapragasam","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.eururo.2018.06.022_bib0270","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/pcan.2016.72","article-title":"Use of the Prostate Health Index for detection of prostate cancer: results from a large academic practice","volume":"20","author":"Tosoian","year":"2017","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.eururo.2018.06.022_bib0275","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.urology.2016.08.022","article-title":"Risk stratification by urinary prostate cancer gene 3 testing before magnetic resonance imaging-ultrasound fusion-targeted prostate biopsy among men with no history of biopsy","volume":"99","author":"Fenstermaker","year":"2017","journal-title":"Urology"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283818304470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283818304470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T03:43:40Z","timestamp":1661571820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283818304470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0302283818304470"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2018.06.022","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging","name":"articletitle","label":"Article Title"},{"value":"European Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eururo.2018.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}