{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:13:43Z","timestamp":1794590023314,"version":"4.9.1"},"reference-count":115,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"am","delay-in-days":348,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.eururo.2019.02.038","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T03:42:16Z","timestamp":1553571736000},"page":"988-1000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":420,"title":["A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment"],"prefix":"10.1016","volume":"75","author":[{"given":"Benoit","family":"Peyronnet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Mironska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chapple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Oelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Dmochowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Amarenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gam\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Van Der Aa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Nicolas","family":"Cornu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eururo.2019.02.038_bib0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/nau.10052","article-title":"The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society","volume":"21","author":"Abrams","year":"2002","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0010","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.eururo.2017.01.037","article-title":"Persistence and adherence with mirabegron versus antimuscarinic agents in patients with overactive bladder: a retrospective observational study in UK clinical practice","volume":"72","author":"Chapple","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0015","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1001\/jama.2016.14617","article-title":"Onabotulinumtoxin A vs sacral neuromodulation on refractory urgency urinary incontinence in wom a randomized clinical trial","volume":"316","author":"Amundsen","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.eururo.2019.02.038_bib0020","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.eururo.2009.07.044","article-title":"A refocus on the bladder as the originator of storage lower urinary tract symptoms: a systematic review of the latest literature","volume":"56","author":"Roosen","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0025","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/nau.23170","article-title":"Can we create a valid treatment algorithm for patients with drug resistant overactive bladder (OAB) syndrome or detrusor overactivity (DO)? Results from a think tank (ICI-RS 2015)","volume":"36","author":"Apostolidis","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0030","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0140-6736(01)05549-0","article-title":"Model of peripheral autonomous modules and a myovesical plexus in normal and overactive bladder function","volume":"358","author":"Drake","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.eururo.2019.02.038_bib0035","doi-asserted-by":"crossref","first-page":"F687","DOI":"10.1152\/ajprenal.00156.2017","article-title":"Spatiotemporal analysis of spontaneous myogenic contractions in the urinary bladder of the rabbit: timing and patterns reflect reported electrophysiology","volume":"313","author":"Hulls","year":"2017","journal-title":"Am J Renal Physiol"},{"issue":"Suppl 3","key":"10.1016\/j.eururo.2019.02.038_bib0040","first-page":"S6","article-title":"Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of \u201coveractive bladder\u201d","volume":"33","author":"Chapple","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0045","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00192-016-3225-z","article-title":"Effectiveness of BTX-A and neuromodulation in treating OAB with or without detrusor overactivity: a systematic review","volume":"28","author":"Rachaneni","year":"2017","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0050","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1471-0528.1991.tb15404.x","article-title":"Sensory urgency: how full is your bladder?","volume":"98","author":"Creighton","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0055","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/nau.20482","article-title":"Defining overactive bladder as hypersensitivity","volume":"26","author":"Yamaguchi","year":"2007","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0060","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.urology.2009.10.045","article-title":"Overactive bladder is not only overactive but also hypersensitive","volume":"75","author":"Lee","year":"2010","journal-title":"Urology"},{"issue":"Suppl. 1","key":"10.1016\/j.eururo.2019.02.038_bib0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1471-0528.2004.00469.x","article-title":"Interstitial cells of the bladder: the missing link?","volume":"111","author":"Blyweert","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.eururo.2019.02.038_bib0070","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jcma.2017.03.009","article-title":"Are patients with bladder oversensitivity different from those with urodynamically proven detrusor overactivity in female overactive bladder syndrome?","volume":"80","author":"Chen","year":"2017","journal-title":"J Chin Med Assoc"},{"key":"10.1016\/j.eururo.2019.02.038_bib0075","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/bju.13240","article-title":"On the origin of spontaneous activity in the bladder","volume":"117","author":"Kushida","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2019.02.038_bib0080","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/nau.21246","article-title":"Andersson K-E. Mechanisms of action of botulinum neurotoxins, \u03b23-adrenergic receptor agonists and IPDE5 inhibitors in modulating detrusor function in overactive bladder: ICI-RS 2011","volume":"31","author":"Kanai","year":"2012","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0085","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000480802","article-title":"Bladder biofeedback for the treatment of refractory sensory urgency in adults","volume":"32","author":"Wyndaele","year":"1997","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/nau.21194","article-title":"Antimuscarinic effects on current perception threshold: a prospective placebo control study","volume":"31","author":"Vijaya","year":"2012","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/nau.10082","article-title":"Measuring the sensations of urge and bladder filling during cystometry in urge incontinence and the effects of neuromodulation","volume":"22","author":"Oliver","year":"2003","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/brain\/54.2.177","article-title":"The component reflexes of micturition in the cats, parts 1 and 2","volume":"54","author":"Barrington","year":"1931","journal-title":"Brain"},{"key":"10.1016\/j.eururo.2019.02.038_bib0105","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/00005392-199907000-00069","article-title":"Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability","volume":"162","author":"Jung","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00345-003-0340-5","article-title":"Role of positive urethrovesical feedback in vesical evacuation. The concept of a second micturition reflex: the urethrovesical reflex","volume":"21","author":"Shafik","year":"2003","journal-title":"World J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.purol.2012.04.011","article-title":"Stand up urgency: is this symptom related to a urethral mechanism?","volume":"22","author":"Hubeaux","year":"2012","journal-title":"Prog Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0120","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0022-5347(05)67827-5","article-title":"Surgical treatment for stress urinary incontinence associated with Valsalva induced detrusor instability","volume":"163","author":"Serels","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0125","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00192-011-1406-3","article-title":"Effectiveness of midurethral slings in mixed urinary incontinence: a systematic review and meta-analysis","volume":"22","author":"Jain","year":"2011","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00192-007-0475-9","article-title":"The integral theory of continence","volume":"19","author":"Petros","year":"2008","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/nau.22815","article-title":"Fundamentals and clinical perspective of urethral sphincter instability as a contributing factor in patients with lower urinary tract dysfunction\u2014ICI-RS 2014","volume":"35","author":"Kirschner-Hermanns","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0140","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000293701","article-title":"Combined detrusor instability and stress urinary incontinence: where is the primary pathology?","volume":"26","author":"Koonings","year":"1988","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.eururo.2019.02.038_bib0145","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.juro.2007.03.120","article-title":"Urethral instability and sacral nerve stimulation\u2014a better parameter to predict efficacy?","volume":"178","author":"Groenendijk","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0150","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1464-410X.2007.06980.x","article-title":"Duloxetine compared with placebo for treating women with symptoms of overactive bladder","volume":"100","author":"Steers","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2019.02.038_bib0155","first-page":"5695","article-title":"Urodynamic parameters evolution after artificial urinary sphincter implantation for post-radical prostatectomy incontinence with concomitant bladder dysfunction","volume":"18","author":"Afraa","year":"2011","journal-title":"Can J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/cne.902500404","article-title":"Anatomical and physiological observations on supraspinal control of bladder and urethral sphincter muscles in the cat","volume":"250","author":"Holstege","year":"1986","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0165","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1097\/01.ju.0000177450.34451.97","article-title":"Brain control of normal and overactive bladder","volume":"174","author":"Griffiths","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0170","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/nau.20549","article-title":"Bladder control, urgency, and urge incontinence: evidence from functional brain imaging","volume":"27","author":"Griffiths","year":"2008","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0175","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/nau.21240","article-title":"Brain activity underlying impaired continence control in older women with overactive bladder","volume":"31","author":"Tadic","year":"2012","journal-title":"Neurourol Urodyn"},{"issue":"S4","key":"10.1016\/j.eururo.2019.02.038_bib0180","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1002\/nau.23506","article-title":"Is there \u201cbrain OAB\u201d and how can we recognize it? International Consultation on Incontinence-Research Society (ICI-RS) 2017","volume":"37","author":"Apostolidis","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0185","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.juro.2015.03.102","article-title":"Brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training","volume":"194","author":"Griffiths","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0190","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1464-410X.2006.06521.x","article-title":"Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators","volume":"98","author":"Blok","year":"2006","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2019.02.038_bib0195","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/nau.20651","article-title":"Percutaneous tibial nerve stimulation produces effects on brain activity: study on the modifications of the long latency somatosensory evoked potentials","volume":"28","author":"Finazzi-Agr\u00f2","year":"2009","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0200","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.eururo.2015.02.030","article-title":"The underactive bladder: a new clinical concept?","volume":"68","author":"Chapple","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.eururo.2017.03.045","article-title":"Qualitative exploration of the patient experience of underactive bladder","volume":"72","author":"Uren","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0210","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s11255-016-1382-0","article-title":"A cross-sectional study in the USA of the epidemiology and quality of life of underactive bladder symptoms","volume":"48","author":"Faraj","year":"2016","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0215","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/nau.23010","article-title":"Prediction of sacral neuromodulation treatment success in men with impaired bladder emptying\u2014time for a new diagnostic approach","volume":"36","author":"Rademakers","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0220","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5213\/inj.2015.19.4.293","article-title":"Origin of urgency symptom in underactive bladder: commentary on \u201cunderactive bladder: clinical features, urodynamic parameters, and treatment\u201d","volume":"19","author":"Kim","year":"2015","journal-title":"Int Neurourol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0225","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.purol.2017.04.005","article-title":"Pathophysiology of detrusor underactivity in the elderly","volume":"27","author":"Kerdraon","year":"2017","journal-title":"Prog Urol"},{"issue":"Suppl. 1","key":"10.1016\/j.eururo.2019.02.038_bib0230","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1007\/s11255-014-0809-8","article-title":"Advanced therapeutic directions to treat the underactive bladder","volume":"46","author":"Smith","year":"2014","journal-title":"Int Urol Nephrol"},{"issue":"Suppl. 2","key":"10.1016\/j.eururo.2019.02.038_bib0235","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.21037\/tau.2017.04.07","article-title":"The underactive bladder: diagnosis and surgical treatment options","volume":"6","author":"Gani","year":"2017","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0240","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/ijcp.12518","article-title":"Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies","volume":"69","author":"Bunn","year":"2015","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.eururo.2019.02.038_bib0245","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/pcan.2015.43","article-title":"Metabolic syndrome, inflammation and lower urinary tract symptoms: possible translational links","volume":"19","author":"He","year":"2016","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.eururo.2019.02.038_bib0250","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.juro.2017.04.103","article-title":"Characteristics associated with treatment response and satisfaction in women undergoing onabotulinumtoxin A and sacral neuromodulation for refractory urgency urinary incontinence","volume":"198","author":"Richter","year":"2017","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0255","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/nau.23256","article-title":"Comparing anticholinergic persistence and adherence profiles in overactive bladder patients based on gender, obesity, and major anticholinergic agents","volume":"36","author":"Lua","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0260","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1742-1241.2010.02442.x","article-title":"Do gender, age or lifestyle factors affect responses to antimuscarinic treatment in overactive bladder patients?","volume":"64","author":"Schneider","year":"2010","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.eururo.2019.02.038_bib0265","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1080\/14656566.2016.1233177","article-title":"Beta3-adrenoreceptor agonist mirabegron\u2014a potential antiobesity drug?","volume":"17","author":"Hainer","year":"2016","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.eururo.2019.02.038_bib0270","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejogrb.2015.11.018","article-title":"Impact of body mass index on treatment efficacy of mirabegron for overactive bladder in females","volume":"196","author":"Krhut","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0275","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1124\/jpet.118.249979","article-title":"Beta-3 adrenoreceptor signaling pathways in urothelial and smooth muscle cells in the presence of succinate","volume":"367","author":"Mossa","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.eururo.2019.02.038_bib0280","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.urology.2016.11.008","article-title":"Efficacy of daily low-dose tadalafil for treating overactive bladder: results of a randomized, double-blind, placebo-controlled trial","volume":"100","author":"Chen","year":"2017","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2019.02.038_bib0285","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s11255-017-1671-2","article-title":"Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast","volume":"49","author":"Ding","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0290","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJMoa0806375","article-title":"Weight loss to treat urinary incontinence in overweight and obese women","volume":"360","author":"Subak","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eururo.2019.02.038_bib0295","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.soard.2016.08.019","article-title":"Effect of bariatric surgery on urinary and fecal incontinence: prospective analysis with 1-year follow-up","volume":"13","author":"Ait Said","year":"2017","journal-title":"Surg Obes Relat Dis"},{"key":"10.1016\/j.eururo.2019.02.038_bib0300","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/bju.12943","article-title":"Effects of bariatric surgery on untreated lower urinary tract symptoms: a prospective multicentre cohort study","volume":"115","author":"Luke","year":"2015","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2019.02.038_bib0305","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpsychores.2014.11.019","article-title":"Affective symptoms and the overactive bladder\u2014a systematic review","volume":"78","author":"Vrijens","year":"2015","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.eururo.2019.02.038_bib0310","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1097\/01.ju.0000144142.26242.f3","article-title":"Corticotropin releasing factor: a mediator of emotional influences on bladder function","volume":"172","author":"Klausner","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0315","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ejphar.2017.07.010","article-title":"SN003, a CRF1 receptor antagonist, attenuates depressive-like behavior and detrusor overactivity symptoms induced by 13-cis-retinoic acid in rats","volume":"812","author":"Wr\u00f3bel","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"5 Suppl. 1","key":"10.1016\/j.eururo.2019.02.038_bib0320","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0090-4295(01)01636-3","article-title":"Influence of central serotonergic mechanisms on lower urinary tract function","volume":"59","author":"de Groat","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2019.02.038_bib0325","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/nau.22843","article-title":"The role of serotonergic mechanism in the rat prefrontal cortex for controlling the micturition reflex: an in vivo microdialysis study","volume":"35","author":"Chiba","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0330","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00192-017-3424-2","article-title":"The influence of duloxetine on detrusor overactivity in rats with depression induced by 13-cis-retinoic acid","volume":"29","author":"Wr\u00f3bel","year":"2018","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0335","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1111\/bph.12414","article-title":"Transient receptor potential (TRP) channels: a clinical perspective","volume":"171","author":"Kaneko","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0340","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrurol.2016.95","article-title":"Does central sensitization help explain overactive bladder","volume":"13","author":"Reynolds","year":"2016","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0345","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2016.227","article-title":"Functional urological disorders: a sensitized defence response in the bladder-gut-brain axis","volume":"14","author":"Leue","year":"2017","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0350","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/nau.23356","article-title":"Coexisting depressive symptoms do not limit the benefits of chronic neuromodulation: a study of over 200 patients","volume":"37","author":"Killinger","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0355","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/nau.22809","article-title":"Do we need to know more about the effects of hormones on lower urinary tract dysfunction? ICI-RS 2014","volume":"35","author":"Hanna-Mitchell","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0360","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00345-015-1496-5","article-title":"Changes of muscarinic receptors and connexin-43 expression as a mechanism of overactive bladder in ovariectomized rats","volume":"33","author":"Lee","year":"2015","journal-title":"World J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0365","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1111\/jsm.12686","article-title":"Vulvovaginal Atrophy Terminology Consensus Conference Panel Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and the North American Menopause Society","volume":"11","author":"Portman","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.eururo.2019.02.038_bib0370","first-page":"CD001405","article-title":"Oestrogen therapy for urinary incontinence in post-menopausal women","volume":"10","author":"Cody","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.eururo.2019.02.038_bib0375","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/gme.0b013e3182104977","article-title":"Randomized trial of estradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder","volume":"18","author":"Nelken","year":"2011","journal-title":"Menopause"},{"key":"10.1016\/j.eururo.2019.02.038_bib0380","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/GME.0000000000000708","article-title":"Hormonal influence on the effect of mirabegron treatment for overactive bladder","volume":"23","author":"Kallner","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.eururo.2019.02.038_bib0385","doi-asserted-by":"crossref","first-page":"F1253","DOI":"10.1152\/ajprenal.00238.2016","article-title":"Testosterone decreases urinary bladder smooth muscle excitability via novel signaling mechanism involving direct activation of the BK channels","volume":"311","author":"Hristov","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0390","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/13685538.2013.807426","article-title":"Testosterone supplementation's effects on age-related bladder remodeling\u2014experimental study in rats","volume":"16","author":"de Barros","year":"2013","journal-title":"Aging Male"},{"key":"10.1016\/j.eururo.2019.02.038_bib0395","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00210-017-1355-6","article-title":"Effect of short-term androgen deficiency on bladder contractility and urothelial mediator release","volume":"390","author":"Bravo","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0400","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.juro.2017.07.039","article-title":"Long-term testosterone therapy improves urinary and sexual function, and quality of life in men with hypogonadism: results from a propensity matched subgroup of a controlled registry study","volume":"199","author":"Haider","year":"2018","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0405","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/nau.23006","article-title":"The urinary microbiome and its contribution to lower urinary tract symptoms; ICI-RS 2015","volume":"36","author":"Drake","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0410","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.euf.2016.11.001","article-title":"The urinary tract microbiome in health and disease","volume":"4","author":"Arag\u00f3n","year":"2018","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.eururo.2019.02.038_bib0415","doi-asserted-by":"crossref","first-page":"e01283","DOI":"10.1128\/mBio.01283-14","article-title":"The female urinary microbiome: a comparison of women with and without urgency urinary incontinence","volume":"5","author":"Pearce","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.eururo.2019.02.038_bib0420","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00192-013-2325-2","article-title":"Urinary bacteria in adult women with urgency urinary incontinence","volume":"25","author":"Brubaker","year":"2014","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0425","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00192-015-2847-x","article-title":"Incontinence medication response relates to the female urinary microbiota","volume":"27","author":"Thomas-White","year":"2016","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0430","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fcimb.2016.00078","article-title":"Does the urinary microbiome play a role in urgency urinary incontinence and its severity?","volume":"6","author":"Karstens","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0435","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3389\/fcimb.2017.00488","article-title":"Urinary microbiome and psychological factors in women with overactive bladder","volume":"7","author":"Wu","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0440","doi-asserted-by":"crossref","first-page":"347.e1","DOI":"10.1016\/j.ajog.2015.07.009","article-title":"The female urinary microbiome in urgency urinary incontinence","volume":"213","author":"Pearce","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0445","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/nau.21228","article-title":"Do the urinary bladder and large bowel interact, in sickness or in health? ICI-RS 2011","volume":"31","author":"Malykhina","year":"2012","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0450","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/ijcp.12028","article-title":"Systematic review of the relationship between bladder and bowel function: implications for patient management","volume":"67","author":"Kaplan","year":"2013","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.eururo.2019.02.038_bib0455","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12876-015-0296-0","article-title":"The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection","volume":"15","author":"Persson","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0460","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1464-410X.2012.11591.x","article-title":"Relationship between overactive bladder and irritable bowel syndrome: a large-scale Internet survey in Japan using the overactive bladder symptom score and Rome III criteria","volume":"111","author":"Matsumoto","year":"2013","journal-title":"BJU Int"},{"key":"10.1016\/j.eururo.2019.02.038_bib0465","series-title":"Rome III: the functional gastrointestinal disorders","first-page":"917","article-title":"Rome III diagnostic questionnaire for the adult functional GI disorders (including alarm questions) and scoring algorithm","author":"Thompson","year":"2006"},{"key":"10.1016\/j.eururo.2019.02.038_bib0470","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.urology.2011.06.013","article-title":"Can sacral neuromodulation improve minor incontinence symptoms in doubly incontinent patients successfully treated for major incontinence symptoms?","volume":"79","author":"Caremel","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2019.02.038_bib0475","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jamda.2012.10.021","article-title":"A feasibility study of transcutaneous posterior tibial nerve stimulation for bladder and bowel dysfunction in elderly adults in residential care","volume":"14","author":"Booth","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.eururo.2019.02.038_bib0480","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/JCP.0000000000000599","article-title":"An open-label pilot study of duloxetine in patients with irritable bowel syndrome and comorbid major depressive disorder","volume":"36","author":"Lewis-Fern\u00e1ndez","year":"2016","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0485","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ana.410210502","article-title":"Disorders of the autonomic nervous system: Part 1. Pathophysiology and clinical features","volume":"21","author":"McLeod","year":"1987","journal-title":"Ann Neurol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0490","first-page":"492","article-title":"Activity of the autonomous nervous system measured based on the variability of heart rate in female urinary incontinence","volume":"11","author":"Blanc","year":"2001","journal-title":"Prog Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0495","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.urology.2005.01.029","article-title":"Analysis of heart rate variability in female patients with overactive bladder","volume":"65","author":"Choi","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.eururo.2019.02.038_bib0500","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.juro.2007.08.036","article-title":"Autonomic nervous system activity during bladder filling assessed by heart rate variability analysis in women with idiopathic overactive bladder syndrome or stress urinary incontinence","volume":"178","author":"Hubeaux","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0505","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/nau.21154","article-title":"Evidence for autonomic nervous system dysfunction in females with idiopathic overactive bladder syndrome","volume":"30","author":"Hubeaux","year":"2011","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0510","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00192-012-1738-7","article-title":"Alterations of heart rate variability in women with overactive bladder syndrome","volume":"23","author":"Ben-Dror","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0515","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00345-016-1880-9","article-title":"Is overactive bladder a nervous or bladder disorder? Autonomic imaging in patients with overactive bladder via dynamic pupillometry","volume":"35","author":"Aydogmus","year":"2017","journal-title":"World J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0520","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/nau.22652","article-title":"Impact of sympathetic dysfunction in the etiology of overactive bladder in women: a preliminary study","volume":"35","author":"Ates","year":"2016","journal-title":"Neurourol Urodyn"},{"issue":"6 Suppl.","key":"10.1016\/j.eururo.2019.02.038_bib0525","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.juro.2012.09.079","article-title":"Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA\/SUFU guideline","volume":"188","author":"Gormley","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0530","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.eururo.2017.12.031","article-title":"EAU guidelines on assessment and nonsurgical management of urinary incontinence","volume":"73","author":"Nambiar","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0535","series-title":"6th International Consultation on Incontinence","author":"Abrams","year":"2017"},{"key":"10.1016\/j.eururo.2019.02.038_bib0540","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/nau.22871","article-title":"Screening for depression and anxiety in patients with storage or voiding dysfunction: a retrospective cohort study predicting outcome of sacral neuromodulation","volume":"35","author":"Drossaerts","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0545","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejogrb.2016.07.495","article-title":"Can we predict detrusor overactivity in women with lower urinary tract symptoms? The King's Detrusor Overactivity Score (KiDOS)","volume":"205","author":"Giarenis","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0550","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00192-012-1715-1","article-title":"The role of serum C-reactive protein in women with lower urinary tract symptoms","volume":"23","author":"Hsiao","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.eururo.2019.02.038_bib0555","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.juro.2018.03.129","article-title":"Specific changes in brain activity during urgency in women with overactive bladder after successful sacral neuromodulation: an fMRI study","volume":"200","author":"Weissbart","year":"2018","journal-title":"J Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0560","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/nau.22767","article-title":"Abnormal functional connectivity in women with urgency urinary incontinence: can we predict disease presence and severity in individual women using Rs-fcMRI","volume":"35","author":"Nardos","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0565","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.purol.2014.11.004","article-title":"The role of urinary markers in the assessment and follow-up of lower urinary tract disorders: a literature review","volume":"25","author":"Peyronnet","year":"2015","journal-title":"Prog Urol"},{"key":"10.1016\/j.eururo.2019.02.038_bib0570","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/nau.22195","article-title":"How does the urothelium affect bladder function in health and disease? ICI-RS 2011","volume":"31","author":"Birder","year":"2012","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.eururo.2019.02.038_bib0575","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/nau.20613","article-title":"Desmopressin, as a \u201cdesigner drug,\u201d in the treatment of overactive bladder syndrome","volume":"28","author":"Hashim","year":"2009","journal-title":"Neurourol Urodyn"}],"container-title":["European Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283819301861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0302283819301861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T13:05:59Z","timestamp":1759583159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0302283819301861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":115,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0302283819301861"],"URL":"https:\/\/doi.org\/10.1016\/j.eururo.2019.02.038","relation":{},"ISSN":["0302-2838"],"issn-type":[{"value":"0302-2838","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment","name":"articletitle","label":"Article Title"},{"value":"European Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eururo.2019.02.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}