{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:45:29Z","timestamp":1792449929943,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.exer.2005.06.010","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T11:31:28Z","timestamp":1124451088000},"page":"210-218","source":"Crossref","is-referenced-by-count":77,"title":["Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: Comparison of Balb\/c and C57BL\/6 mice"],"prefix":"10.1016","volume":"82","author":[{"given":"Atsuki","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waka","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyo","family":"Fukata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2005.06.010_bib1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.exer.2005.06.010_bib2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S1357-4310(99)01479-3","article-title":"Recent advances in the genetics of allergy and asthma","volume":"5","author":"Anderson","year":"1999","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.exer.2005.06.010_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00004397-199303320-00009","article-title":"Atopic ocular disease","volume":"33","author":"Barney","year":"1993","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.exer.2005.06.010_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1074-7613(04)00080-9","article-title":"Immune sensitization in the skin is enhanced by antigen-independent effects of IgE","volume":"20","author":"Bryce","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2005.06.010_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/08830180212063","article-title":"Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis","volume":"21","author":"Caspi","year":"2002","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib6","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.8456300","article-title":"Multiple defects of immune cell function in mice with disrupted interferon-gamma genes","volume":"259","author":"Dalton","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.exer.2005.06.010_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.iy.11.040193.000333","article-title":"Differential regulation of murine T lymphocyte subsets","volume":"11","author":"Fitch","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1348-0421.2003.tb03436.x","article-title":"Differential expression and signaling of IFN-gamma in the conjunctiva between Lewis and Brown Norway rats","volume":"47","author":"Fukushima","year":"2003","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib9","doi-asserted-by":"crossref","unstructured":"Fukushima A, Yamaguchi T, Ishida W, Fukata K, Ozaki A, Ueno H., in press. The immunization protocol determines whether endogenous interferon-\u03b3 suppresses the infiltration of eosinophils into the conjunctiva. Immunol. Lett.","DOI":"10.1016\/j.imlet.2005.04.012"},{"key":"10.1016\/j.exer.2005.06.010_bib10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.271.5251.984","article-title":"Genetic susceptibility to Leishmania: IL12 responsiveness in TH1 cell development","volume":"271","author":"Guler","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.exer.2005.06.010_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI5155","article-title":"Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation","volume":"103","author":"Hansen","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2005.06.010_bib12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1046\/j.1365-2222.1998.00280.x","article-title":"Various immunological phenotypes are associated with increased airway responsiveness","volume":"28","author":"Herz","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.exer.2005.06.010_bib13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.181.2.713","article-title":"T cell genetic background determines default T helper phenotype development in vitro","volume":"181","author":"Hsieh","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2005.06.010_bib14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s004170050363","article-title":"Experimental immune-mediated blepharoconjunctivitis in rats induced by immunization with ragweed pollen","volume":"238","author":"Iwamoto","year":"2000","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2005.06.010_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-065X.1991.tb00607.x","article-title":"Heterogeneity in lymphokine profiles of CD4+ and CD8+T cells and clones activated in vivo and in vitro","volume":"123","author":"Kelso","year":"1991","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.exer.2005.06.010_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1089\/hyb.1984.3.277","article-title":"Mouse monoclonal IgE antibodies specific for ragweed pollen antigens","volume":"3","author":"Liu","year":"1984","journal-title":"Hybridoma"},{"key":"10.1016\/j.exer.2005.06.010_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/clin.1997.4507","article-title":"A novel murine model of allergic conjunctivitis","volume":"87","author":"Magone","year":"1998","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.exer.2005.06.010_bib18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0091-6749(00)90080-0","article-title":"The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis","volume":"105","author":"Magone","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0008-8749(92)90017-J","article-title":"B cell sensitivity to IgE-suppressive activity of IFN-gamma is polymorphic and controlled by a non-H-2-linked gene","volume":"143","author":"Matsushita","year":"1992","journal-title":"Cell Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/eji.1830260138","article-title":"Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge","volume":"26","author":"Menon","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/08830189709116843","article-title":"Pathogenic gene responsible for the predisposition of Behcet's disease","volume":"14","author":"Mizuki","year":"1997","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1365-2567.1999.00890.x","article-title":"C57BL\/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALB\/c mice, irrespective of systemic T helper 1\/T helper 2 responses","volume":"98","author":"Morokata","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.exer.2005.06.010_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"Th1 and Th2 cells: different patterns of lymphokine secretion lead to different function properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib24","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1172\/JCI7631","article-title":"Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation","volume":"104","author":"Randolph","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2005.06.010_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.iy.13.040195.001055","article-title":"The regulation of immunity to Leishmania major","volume":"13","author":"Reiner","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.010_bib26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1076\/ceyr.18.2.117.5383","article-title":"Genetic background determines the nature of immune responses and experimental immune-mediated blepharoconjunctivitis (EC)","volume":"18","author":"Yoshida","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2005.06.010_bib27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1164\/ajrccm.155.2.9032210","article-title":"Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response","volume":"155","author":"Zhang","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.exer.2005.06.010_bib28","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/eji.1830260926","article-title":"Differential expression of interleukin-5 mRNA+ cells and eosinophils in Nippostrongylus brasiliensis infection in resistant and susceptible strains of mice","volume":"26","author":"Zhou","year":"1996","journal-title":"Eur. J. Immunol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483505001855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483505001855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,17]],"date-time":"2019-03-17T09:03:43Z","timestamp":1552813423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483505001855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0014483505001855"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2005.06.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}