{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:28:38Z","timestamp":1789381718029,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.exer.2005.06.023","type":"journal-article","created":{"date-parts":[[2005,8,27]],"date-time":"2005-08-27T07:08:27Z","timestamp":1125126507000},"page":"275-281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"82","author":[{"given":"Yukari","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ohgami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Shiratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hai","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliyana","family":"Ilieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunaga","family":"Yazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2005.06.023_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(00)81318-5","article-title":"NF-kappa B: ten years after","volume":"87","author":"Baeuerle","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.exer.2005.06.023_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappa B in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.023_bib3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exer.2005.06.023_bib4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2005.06.023_bib5","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.6.10.1899","article-title":"I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention","volume":"6","author":"Beg","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2005.06.023_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF02285162","article-title":"Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit","volume":"45","author":"Bellot","year":"1996","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.exer.2005.06.023_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-2478(99)00145-5","article-title":"Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes","volume":"70","author":"Bennedsen","year":"1999","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.exer.2005.06.023_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0014-2999(01)01233-X","article-title":"In vivo regulation of vasomotricity by nitric oxide and prostanoids during gestation","volume":"427","author":"Boujedaini","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2005.06.023_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jcb.1184","article-title":"Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages","volume":"82","author":"Chen","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exer.2005.06.023_bib10","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.mad.2004.08.009","article-title":"Nuclear factor kappa B activation by NADPH oxidases","volume":"125","author":"Clark","year":"2004","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exer.2005.06.023_bib11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1096\/fasebj.9.10.7542214","article-title":"Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers","volume":"9","author":"Collins","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2005.06.023_bib12","first-page":"3873","article-title":"Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat","volume":"35","author":"de Vos","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.06.023_bib13","first-page":"1100","article-title":"Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat","volume":"35","author":"de Vos","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.06.023_bib14","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/01.RES.84.9.1085","article-title":"Very low-density lipoprotein activates nuclear factor-kappaB in endothelial cells","volume":"84","author":"Dichtl","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.exer.2005.06.023_bib15","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.4049\/jimmunol.154.12.6518","article-title":"Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase","volume":"154","author":"Goureau","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2005.06.023_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/02713689008999430","article-title":"Endotoxin-induced uveitis in the rat: a hypothesis for preferential involvement of the anterior uvea","volume":"9 Suppl","author":"Herbort","year":"1990","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2005.06.023_bib17","first-page":"27","article-title":"Inhibition of oxidative injury of biological membranes by astaxanthin","volume":"22","author":"Kurashige","year":"1990","journal-title":"Physiol. Chem. Phys. Med. NMR"},{"key":"10.1016\/j.exer.2005.06.023_bib18","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1890::AID-IMMU1890>3.0.CO;2-F","article-title":"Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha","volume":"29","author":"Lauzurica","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exer.2005.06.023_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1016-8478(23)13772-1","article-title":"Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation","volume":"16","author":"Lee","year":"2003","journal-title":"Mol. Cells"},{"key":"10.1016\/j.exer.2005.06.023_bib20","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/01.CIR.100.12.1330","article-title":"Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes","volume":"100","author":"Liu","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2005.06.023_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0167-5699(97)01197-3","article-title":"Signal transduction through NF-kappa B","volume":"19","author":"May","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/j.exer.2005.06.023_bib22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/exer.1997.0323","article-title":"Cellular localisation and dynamics of nitric oxide synthase expression in the rat anterior segment during endotoxin-induced uveitis","volume":"65","author":"McMenamin","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.06.023_bib23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/exer.1998.0618","article-title":"Role and regulation of IL-8 and MCP-1 in LPS-induced uveitis in rabbits","volume":"68","author":"Mo","year":"1999","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.06.023_bib24","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.bcp.2004.07.016","article-title":"Quercetin prevents oxidative stress and NF-kappaB activation in gastric mucosa of portal hypertensive rats","volume":"68","author":"Moreira","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2005.06.023_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-5793(97)01355-0","article-title":"Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants","volume":"418","author":"Mortensen","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2005.06.023_bib26","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1182\/blood.V88.9.3482.bloodjournal8893482","volume":"88","author":"Munoz","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.exer.2005.06.023_bib27","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/carcin\/21.10.1843","article-title":"Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation","volume":"21","author":"Murakami","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exer.2005.06.023_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00024382-199807000-00009","article-title":"Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin","volume":"10","author":"Nemeth","year":"1998","journal-title":"Shock"},{"key":"10.1016\/j.exer.2005.06.023_bib29","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1021\/bi002498n","article-title":"Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage","volume":"40","author":"Neuzil","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2005.06.023_bib31","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1167\/iovs.02-0822","article-title":"Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo","volume":"44","author":"Ohgami","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.06.023_bib32","first-page":"744","article-title":"Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in Lewis rats","volume":"43","author":"Ohta","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.06.023_bib30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0167-5699(00)01611-X","article-title":"The IL-1 receptor\/toll-like receptor superfamily: crucial receptors for inflammation and host defense","volume":"21","author":"O'Neill","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1016\/j.exer.2005.06.023_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0891-5849(97)00137-8","article-title":"N-Acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes","volume":"24","author":"Pahan","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2005.06.023_bib34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/1074-7613(94)90093-0","article-title":"CD14 is a pattern recognition receptor","volume":"1","author":"Pugin","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2005.06.023_bib35","doi-asserted-by":"crossref","first-page":"30188","DOI":"10.1074\/jbc.M102061200","article-title":"Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B","volume":"276","author":"Sanlioglu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2005.06.023_bib36","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1084\/jem.175.5.1181","article-title":"Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells","volume":"175","author":"Schreck","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2005.06.023_bib37","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0006-2952(95)02011-Z","article-title":"Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes","volume":"50","author":"Schulze-Osthoff","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2005.06.023_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1124\/mol.54.2.273","article-title":"Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene","volume":"54","author":"Sewer","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2005.06.023_bib39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/B:MCBI.0000038233.20276.e0","article-title":"Inhibition of nuclear factor-kappa B prevents staphylococcal enterotoxin A-induced fever","volume":"262","author":"Shao","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exer.2005.06.023_bib40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.med.45.1.491","article-title":"Tumor necrosis factor: a pleiotropic cytokine and therapeutic target","volume":"45","author":"Tracey","year":"1994","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.exer.2005.06.023_bib41","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/330662a0","article-title":"Anti-cachectin\/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia","volume":"330","author":"Tracey","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.exer.2005.06.023_bib42","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/ijc.20433","article-title":"Arsenic trioxide sensitizes CD95\/Fas-induced apoptosis through ROS-mediated upregulation of CD95\/Fas by NF-kappaB activation","volume":"112","author":"Woo","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.exer.2005.06.023_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1172\/JCI11914","article-title":"Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer","volume":"107","author":"Yamamoto","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2005.06.023_bib44","first-page":"77","article-title":"Macrophages in the retina of normal Lewis rats and their dynamics after injection of lipopolysaccharide","volume":"37","author":"Yang","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.06.023_bib45","first-page":"1107","article-title":"Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis","volume":"35","author":"Yoshida","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448350500196X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448350500196X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:50:40Z","timestamp":1757998240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448350500196X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S001448350500196X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2005.06.023","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2005.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}