{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:19:24Z","timestamp":1778545164784,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.exer.2005.10.032","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T13:45:47Z","timestamp":1142343947000},"page":"51-60","source":"Crossref","is-referenced-by-count":17,"title":["The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models"],"prefix":"10.1016","volume":"83","author":[{"given":"Elaine C.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William O.","family":"Cepurna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2005.10.032_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators","volume":"130","author":"AGIS-Investigators","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib2","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1167\/iovs.03-1123","article-title":"Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure","volume":"45","author":"Ahmed","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0736-5748(00)00073-3","article-title":"Effects of increased intraocular pressure on rat retinal ganglion cells","volume":"19","author":"Ahmed","year":"2001","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.exer.2005.10.032_bib4","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1167\/iovs.04-0731","article-title":"Effect of glatiramer acetate on primary and secondary degeneration of retinal ganglion cells in the rat","volume":"46","author":"Blair","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1167\/iovs.04-0421","article-title":"The gradient of retinal functional changes during acute intraocular pressure elevation","volume":"46","author":"Bui","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2005.10.032_bib6","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S0039-6257(96)82027-3","article-title":"Preclinical evaluation of brimonidine","volume":"41","author":"Burke","year":"1996","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1006\/exer.2001.0990","article-title":"Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina","volume":"72","author":"Cao","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.exer.2004.12.021","article-title":"Age related optic nerve axonal loss in adult Brown Norway rats","volume":"80","author":"Cepurna","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0006-8993(01)02499-4","article-title":"Topically applied clonidine protects the rat retina from ischaemia\/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors","volume":"904","author":"Chao","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2005.10.032_bib10","first-page":"2969","article-title":"Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage","volume":"43","author":"Chauhan","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.exer.2005.10.032_bib12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0002-9394(98)00272-4","article-title":"The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma Study Group","volume":"126","author":"CNTGS-Investigators","year":"1998","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/1047-8477(92)90014-2","article-title":"Glial fibrillary acidic protein and its mRNA: ultrastructural detection and determination of changes after CNS injury","volume":"108","author":"Erickson","year":"1992","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.exer.2005.10.032_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s004010000319","article-title":"Differential activation of microglial cells in local and remote areas of IRBP1169-1191-induced rat uveitis","volume":"101","author":"Fauser","year":"2001","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.exer.2005.10.032_bib15","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1167\/iovs.03-1411","article-title":"Selective ganglion cell functional loss in rats with experimental glaucoma","volume":"45","author":"Fortune","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0042-6989(01)00194-8","article-title":"Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye","volume":"42","author":"Goldblum","year":"2002","journal-title":"Vision Res."},{"key":"10.1016\/j.exer.2005.10.032_bib17","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1076\/ceyr.25.6.389.14233","article-title":"Activation of caspase 9 in a rat model of experimental glaucoma","volume":"25","author":"Hanninen","year":"2002","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib19","first-page":"253","article-title":"Visual field progression in open-angle glaucoma patients presenting with monocular field loss","volume":"81","author":"Harbin","year":"1976","journal-title":"Trans. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"10.1016\/j.exer.2005.10.032_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/10520297409116929","article-title":"A simple methylene blue-azure II-basic fuchsin stain for epoxy-embedded tissue sections","volume":"49","author":"Humphrey","year":"1974","journal-title":"Stain Technol."},{"key":"10.1016\/j.exer.2005.10.032_bib21","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.STR.32.5.1208","article-title":"Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain","volume":"32","author":"Ito","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.exer.2005.10.032_bib22","first-page":"3415","article-title":"Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction","volume":"41","author":"Jia","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib23","first-page":"1380","article-title":"Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats","volume":"41","author":"Jia","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib24","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0014-4835(86)80031-8","article-title":"Retrograde axoplasmic transport in rat optic nerve in vivo. What causes blockage at increased intraocular pressure?","volume":"43","author":"Johansson","year":"1986","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib25","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00061198-199912000-00011","article-title":"Mouse genetics: a tool to help unlock the mechanisms of glaucoma","volume":"8","author":"John","year":"1999","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2005.10.032_bib26","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"Kass","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archopht.121.1.48","article-title":"Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial","volume":"121","author":"Leske","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib29","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.eye.6701576","article-title":"Animal models of optic nerve diseases","volume":"18","author":"Levkovitch-Verbin","year":"2004","journal-title":"Eye"},{"key":"10.1016\/j.exer.2005.10.032_bib30","first-page":"402","article-title":"Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats","volume":"43","author":"Levkovitch-Verbin","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib31","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1167\/iovs.02-0646","article-title":"A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection","volume":"44","author":"Levkovitch-Verbin","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib32","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1523\/JNEUROSCI.13-06-02617.1993","article-title":"Temporal changes in beta-tubulin and neurofilament mRNA levels after transection of adult rat retinal ganglion cell axons in the optic nerve","volume":"13","author":"McKerracher","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2005.10.032_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbrainres.2003.10.003","article-title":"Iba1-expressing microglia respond to herpes simplex virus infection in the mouse trigeminal ganglion","volume":"120","author":"Mori","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.exer.2005.10.032_bib34","first-page":"12","article-title":"Animal models in glaucoma research","volume":"16","author":"Morrison","year":"1998","journal-title":"Ophthalmic Pract."},{"key":"10.1016\/j.exer.2005.10.032_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.preteyeres.2004.08.003","article-title":"Understanding mechanisms of pressure-induced optic nerve damage","volume":"24","author":"Morrison","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/exer.1996.0184","article-title":"A rat model of chronic pressure-induced optic nerve damage","volume":"64","author":"Morrison","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib37","first-page":"526","article-title":"Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma","volume":"39","author":"Morrison","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib38","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.ophtha.2004.02.017","article-title":"Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study","volume":"111","author":"Nouri-Mahdavi","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2005.10.032_bib39","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1167\/iovs.04-0204","article-title":"Prediction of visual field progression in glaucoma","volume":"45","author":"Nouri-Mahdavi","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2005.10.032_bib40","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S0039-6257(99)00044-2","article-title":"Neuroprotection in relation to retinal ischemia and relevance to glaucoma","volume":"43","author":"Osborne","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib41","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1167\/iovs.04-0829","article-title":"Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage","volume":"46","author":"Pang","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.exer.2004.09.001","article-title":"Acute effects of glaucoma medications on rat intraocular pressure","volume":"80","author":"Pang","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib43","first-page":"2303","article-title":"Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure","volume":"42","author":"Pena","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1442-9071.1989.tb00502.x","article-title":"Experimental compounds to lower intraocular pressure","volume":"17","author":"Podos","year":"1989","journal-title":"Aust. N. Z. J. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-5728(99)00222-2","article-title":"Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions","volume":"104","author":"Postler","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.exer.2005.10.032_bib46","first-page":"3460","article-title":"Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats","volume":"41","author":"Quigley","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 2","key":"10.1016\/j.exer.2005.10.032_bib47","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/S0039-6257(97)80007-0","article-title":"Structure-activity relationships and receptor profiles of some ocular hypotensive prostanoids","volume":"41","author":"Resul","year":"1997","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib48","first-page":"192","article-title":"Changes in Thy1 gene expression associated with damaged retinal ganglion cells","volume":"7","author":"Schlamp","year":"2001","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2005.10.032_bib49","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00061198-200404000-00007","article-title":"Increased rate of visual field loss associated with larger initial visual field threshold values on follow-up of open-angle glaucoma","volume":"13","author":"Schwartz","year":"2004","journal-title":"J. Glaucoma."},{"key":"10.1016\/j.exer.2005.10.032_bib50","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00061198-199612000-00012","article-title":"Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration","volume":"5","author":"Schwartz","year":"1996","journal-title":"J. Glaucoma."},{"key":"10.1016\/j.exer.2005.10.032_bib51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(05)80131-9","article-title":"Chronic ocular hypertension following episcleral venous occlusion in rats","volume":"61","author":"Shareef","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.exer.2004.02.005","article-title":"Correlation between retinal ganglion cell death and chronically developing inherited glaucoma in a new rat mutant","volume":"79","author":"Thanos","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2005.10.032_bib53","first-page":"1745","article-title":"Effect of intraocular pressure on uveoscleral outflow following cyclodialysis in the monkey eye","volume":"26","author":"Toris","year":"1985","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2005.10.032_bib54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/jop.2000.16.19","article-title":"Aqueous humor dynamics in monkeys with laser-induced glaucoma","volume":"16","author":"Toris","year":"2000","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2005.10.032_bib55","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0021-5155(98)00026-4","article-title":"Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink","volume":"42","author":"Ueda","year":"1998","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2005.10.032_bib56","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1523\/JNEUROSCI.15-11-07377.1995","article-title":"Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina","volume":"15","author":"Wen","year":"1995","journal-title":"J. Neurosci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506000479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506000479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T04:55:37Z","timestamp":1586753737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483506000479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0014483506000479"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2005.10.032","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}