{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:33:44Z","timestamp":1785270824772,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.exer.2006.03.025","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T09:17:20Z","timestamp":1150276640000},"page":"890-896","source":"Crossref","is-referenced-by-count":34,"title":["Aging changes of mouse corneal endothelium and Descemet's membrane"],"prefix":"10.1016","volume":"83","author":[{"given":"Albert S.","family":"Jun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukti","family":"Chakravarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F.","family":"Edelhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Kimos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2006.03.025_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00003226-200201000-00001","article-title":"Summary of comeal transplant activity Eye Bank Association of America","volume":"21","author":"Aiken-O'Neill","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2006.03.025_bib2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1136\/bjo.2003.031948","article-title":"Penetrating keratoplasty: indications over a 10year period","volume":"88","author":"Al-Yousuf","year":"2004","journal-title":"Br. J. Ophthalmol"},{"key":"10.1016\/j.exer.2006.03.025_bib3","first-page":"2784","article-title":"Corneal endothelial integrity in mice lacking extracellular superoxide dismutase","volume":"42","author":"Behndig","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib4","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/hmg\/10.21.2415","article-title":"Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy","volume":"10","author":"Biswas","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.03.025_bib5","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/sj.eye.6700559","article-title":"Biology of the corneal endothelium in health and disease","volume":"17","author":"Bourne","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.exer.2006.03.025_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/exer.2001.1055","article-title":"The cornea through the eyes of knockout mice","volume":"73","author":"Chakravarti","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2006.03.025_bib7","series-title":"Scientific Tables, CIBA-Geigy","author":"Diem","year":"1970"},{"key":"10.1016\/j.exer.2006.03.025_bib8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/00003226-200011000-00010","article-title":"Trends in the indications for penetrating keratoplasty in the midwestern United States","volume":"19","author":"Dobbins","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2006.03.025_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0531-5565(86)90015-X","article-title":"Age-related changes in the corneal endothelium of the mouse","volume":"21","author":"Fitch","year":"1986","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exer.2006.03.025_bib10","first-page":"254","article-title":"Morphometric analysis of the corneal endothelium. Specular microscopy vs. alizarin red staining","volume":"30","author":"Geroski","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib11","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1167\/iovs.04-0937","article-title":"Inheritance of a novel COL8A2 mutation defines a distinct early-onset subtype of fuchs corneal dystrophy","volume":"46","author":"Gottsch","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib12","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1167\/iovs.05-0497","article-title":"Fuchs corneal dystrophy: aberrant collagen distribution in an L450W mutant of the COL8A2 gene","volume":"46","author":"Gottsch","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/jmor.10030","article-title":"Comparative observations on corneas, with special reference to Bowman's layer and Descemet's membrane in mammals and amphibians","volume":"254","author":"Hayashi","year":"2002","journal-title":"J. Morphol."},{"key":"10.1016\/j.exer.2006.03.025_bib14","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1096\/fj.04-3019com","article-title":"Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye","volume":"19","author":"Hopfer","year":"2005","journal-title":"Faseb J"},{"key":"10.1016\/j.exer.2006.03.025_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0002-9394(54)90008-2","article-title":"Studies on the cornea. I. The fine structure of the rat cornea","volume":"38","author":"Jakus","year":"1954","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.03.025_bib16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1083\/jcb.2.4.243","article-title":"Studies on the cornea. II. The fine structure of Descement's membrane","volume":"2","author":"Jakus","year":"1956","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10.1016\/j.exer.2006.03.025_bib17","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1001\/archopht.1982.01030040922011","article-title":"The ultrastructure of Descemet's membrane. I. Changes with age in normal corneas","volume":"100","author":"Johnson","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2006.03.025_bib18","first-page":"287","article-title":"An improved electron stain for elastic fibers using tannic acid","volume":"24","author":"Kajikawa","year":"1975","journal-title":"J. Electron. Microsc. (Tokyo)"},{"key":"10.1016\/j.exer.2006.03.025_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1167\/iovs.01-1257","article-title":"Expression of type XVIII collagen during healing of corneal incisions and keratectomy wounds","volume":"44","author":"Kato","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib20","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1001\/archopht.1978.03910060424004","article-title":"Corneal endothelial dystrophy. A study of 64 families","volume":"96","author":"Krachmer","year":"1978","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2006.03.025_bib21","first-page":"15","article-title":"Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet's membrane","volume":"6","author":"Leung","year":"2000","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2006.03.025_bib22","first-page":"2517","article-title":"Matrilysin cleavage of corneal collagen type XVIII NC1 domain and generation of a 28-kDa fragment","volume":"42","author":"Lin","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0002-9394(67)93073-5","article-title":"Central cornea guttata. Incidence in the general population","volume":"64","author":"Lorenzetti","year":"1967","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.03.025_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/00006324-200212000-00008","article-title":"Assessments of corneal endothelial cell density in growing children and its relationship to horizontal corneal diameter","volume":"79","author":"M\u00fcller","year":"2002","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1136\/bjo.84.7.692","article-title":"Reassessment of the corneal endothelial cell organisation in children","volume":"84","author":"M\u00fcller","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.03.025_bib26","first-page":"1402","article-title":"Prenatal and postnatal growth of the human Descemet's membrane","volume":"25","author":"Murphy","year":"1984","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.03.025_bib27","unstructured":"Online Mendelian Inheritance in Man (OMIM), 2006. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD). http:\/\/www.ncbi.nlm.nih.gov\/omim\/"},{"key":"10.1016\/j.exer.2006.03.025_bib28","first-page":"28","article-title":"Fine structure of the mouse cornea","volume":"20","author":"Rehbinder","year":"1978","journal-title":"Z. Versuchstierkd"},{"key":"10.1016\/j.exer.2006.03.025_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.110.1.219","article-title":"Characterization of the collagen in the hexagonal lattice of Descemet's membrane: its relation to type VIII collagen","volume":"110","author":"Sawada","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2006.03.025_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF01457411","article-title":"Immunostaining of a heterodimeric dermatan sulphate proteoglycan is correlated with smooth muscles and some basement membranes","volume":"103","author":"Schittny","year":"1995","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.exer.2006.03.025_bib31","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1083\/jcb.107.4.1599","article-title":"High resolution immunoelectron microscopic localization of functional domains of laminin, nidogen, and heparan sulfate proteoglycan in epithelial basement membrane of mouse cornea reveals different topological orientations","volume":"107","author":"Schittny","year":"1988","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2006.03.025_bib32","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.visres.2004.03.011","article-title":"A paraxial schematic eye model for the growing C57BL\/6 mouse","volume":"44","author":"Schmucker","year":"2004","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2006.03.025_bib33","series-title":"Diagnostic Electron Microscopy","author":"Trump","year":"1978"},{"key":"10.1016\/j.exer.2006.03.025_bib34","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0161-6420(92)31812-3","article-title":"Corneal diameter, axial length, and intraocular pressure in premature infants","volume":"99","author":"Tucker","year":"1992","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2006.03.025_bib35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0161-6420(82)34746-6","article-title":"The corneal endothelium. Normal and pathologic structure and function","volume":"89","author":"Waring","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2006.03.025_bib36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3109\/02713688509017661","article-title":"Changes in the normal corneal endothelial cellular pattern as a function of age","volume":"4","author":"Yee","year":"1985","journal-title":"Curr. Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T14:58:01Z","timestamp":1547564281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483506002223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0014483506002223"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2006.03.025","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}