{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:56:18Z","timestamp":1791608178671,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.exer.2006.05.019","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T10:01:21Z","timestamp":1152612081000},"page":"1118-1127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion"],"prefix":"10.1016","volume":"83","author":[{"given":"Robert E.","family":"MacLaren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek K.","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaljit S.","family":"Balaggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus","family":"MacNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville N.","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2006.05.019_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/104303401450988","article-title":"Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column","volume":"12","author":"Auricchio","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2006.05.019_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0306-4522(84)90195-7","article-title":"Thy-1 antigen: a ganglion cell specific marker in rodent retina","volume":"11","author":"Barnstable","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2006.05.019_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1006\/exer.2002.1176","article-title":"Effects of Adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds\/peripherin mutation","volume":"74","author":"Bok","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2006.05.019_bib4","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1167\/iovs.03-1342","article-title":"Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: Dose-dependent effects on ERG and retinal histology","volume":"45","author":"Bush","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/exer.1997.0328","article-title":"Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina","volume":"65","author":"Cao","year":"1997","journal-title":"Exp Eye Res."},{"key":"10.1016\/j.exer.2006.05.019_bib6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1167\/iovs.03-0674","article-title":"The effect of retinal ganglion cell injury on light-induced photoreceptor degeneration","volume":"45","author":"Casson","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib7","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1523\/JNEUROSCI.22-10-03977.2002","article-title":"TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo","volume":"22","author":"Cheng","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0306-4522(99)00320-6","article-title":"Ciliary neurotrophic factor promotes the regrowth capacity but not the survival of intraorbitally axotomized retinal ganglion cells in adult hamsters","volume":"94","author":"Cho","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2006.05.019_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(98)00672-7","article-title":"Systemic administration of acidic fibroblast growth factor ameliorates the ischemic injury of the retina in rats","volume":"255","author":"Cuevas","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2006.05.019_bib10","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1097\/00001756-200012180-00019","article-title":"CNTF promotes the regrowth of retinal ganglion cell axons into murine peripheral nerve grafts","volume":"11","author":"Cui","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.exer.2006.05.019_bib11","first-page":"587","article-title":"Cytoarchitecture of the retinal ganglion cells in the rat","volume":"43","author":"Danias","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib12","first-page":"3943","article-title":"Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture","volume":"41","author":"Fischer","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1350-9462(00)00028-8","article-title":"Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye","volume":"20","author":"Flammer","year":"2001","journal-title":"Prog. Retinal Eye Res."},{"key":"10.1016\/j.exer.2006.05.019_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0306-4522(03)00599-2","article-title":"Potential role of glial cell line derived neurotrophic factor receptors in M\u00fcller glial cells during light-induced retinal degeneration","volume":"122","author":"Harada","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2006.05.019_bib15","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","article-title":"Microglia-M\u00fcller glial cell interactions control ciliary neurotrophic factor production during light-induced retinal degeneration","volume":"22","author":"Harada","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/mcne.2002.1168","article-title":"Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors","volume":"21","author":"Harvey","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ymthe.2005.01.016","article-title":"Lentiviral-mediated transfer of CNTF to Schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration","volume":"11","author":"Hu","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2006.05.019_bib18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1096-9861(19970825)385:2<309::AID-CNE9>3.0.CO;2-5","article-title":"Retinal ganglion cells in the albino rat: Revised morphological classification","volume":"385","author":"Huxlin","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2006.05.019_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.0953-816X.2003.03107.x","article-title":"CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway","volume":"19","author":"Ji","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0002-9394(88)90835-5","article-title":"Progression of visual defects in ischemic optic neuropathy","volume":"106","author":"Kline","year":"1988","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.05.019_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2004.09.038","article-title":"Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats","volume":"1029","author":"Li","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2006.05.019_bib22","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/bjo.80.5.458","article-title":"Development and role of retinal glia in regeneration of ganglion cells following retinal injury","volume":"80","author":"MacLaren","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.05.019_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/exnr.1997.6620","article-title":"Chiasmatic specificity in the regenerating mammalian optic nerve","volume":"147","author":"MacLaren","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2006.05.019_bib24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0301-0082(97)00041-5","article-title":"Regeneration in the developing optic nerve: Correlating observations in the opossum to other mammalian systems","volume":"53","author":"MacLaren","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.exer.2006.05.019_bib25","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1167\/iovs.02-1332","article-title":"Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model","volume":"44","author":"Martin","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.icu.0000188361.52166.93","article-title":"Nonarteritic anterior ischemic optic neuropathy","volume":"16","author":"Matthews","year":"2005","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2006.05.019_bib27","first-page":"2401","article-title":"Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult rats","volume":"43","author":"Mo","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib28","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1136\/bjo.85.10.1252","article-title":"A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma","volume":"85","author":"Osborne","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.05.019_bib29","doi-asserted-by":"crossref","first-page":"10806","DOI":"10.1523\/JNEUROSCI.3532-04.2004","article-title":"Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells","volume":"24","author":"Park","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1098\/rspb.1980.0060","article-title":"Amacrine cells, displaced amacrine cells and interplexiform cells in the retina of the rat","volume":"208","author":"Perry","year":"1980","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib31","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1523\/JNEUROSCI.20-11-04081.2000","article-title":"Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia","volume":"20","author":"Peterson","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib32","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1167\/iovs.04-1070","article-title":"Glaucoma: Macrocosm to Microcosm The Friedenwald Lecture","volume":"46","author":"Quigley","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/sj.gt.3301929","article-title":"Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2\/Rd2 model of retinal degeneration","volume":"10","author":"Schlichtenbrede","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2006.05.019_bib34","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1073\/pnas.0600236103","article-title":"Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants","volume":"103","author":"Sieving","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2006.05.019_bib35","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0039-6257(94)90145-7","article-title":"Traumatic optic neuropathy","volume":"38","author":"Steinsapir","year":"1994","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2006.05.019_bib36","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1167\/iovs.03-0052","article-title":"Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor","volume":"44","author":"Takita","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0166-2236(94)90098-1","article-title":"Old dyes for new scopes: the phagocytosis-dependent long-term fluorescence labelling of microglial cells in vivo","volume":"17","author":"Thanos","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exer.2006.05.019_bib38","first-page":"907","article-title":"Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor","volume":"35","author":"Unoki","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/104303403321070801","article-title":"Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time","volume":"14","author":"Van Adel","year":"2003","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2006.05.019_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/neu.480240103","article-title":"Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats","volume":"24","author":"Villegas-Perez","year":"1993","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.exer.2006.05.019_bib41","first-page":"927","article-title":"Neurotrophic factors cause activation of intracellular signaling pathways in M\u00fcller cells and other cells of the inner retina, but not photoreceptors","volume":"41","author":"Wahlin","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.05.019_bib42","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1350-9462(02)00037-X","article-title":"Survival and axonal regeneration of retinal ganglion cells in adult cats","volume":"21","author":"Watanabe","year":"2002","journal-title":"Prog. Retinal Eye Res."},{"key":"10.1016\/j.exer.2006.05.019_bib43","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/01.ijg.0000169395.47921.02","article-title":"The importance of models in glaucoma research","volume":"14","author":"Weinreb","year":"2005","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2006.05.019_bib44","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archopht.116.7.906","article-title":"Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve","volume":"116","author":"Yoles","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2006.05.019_bib45","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1089\/10430349950016861","article-title":"High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H","volume":"10","author":"Zhang","year":"1999","journal-title":"Hum Gene Ther."},{"key":"10.1016\/j.exer.2006.05.019_bib46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ymthe.2005.04.004","article-title":"Activation of the extracellular signal-regulated kinase 1\/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma","volume":"12","author":"Zhou","year":"2005","journal-title":"Mol. Ther."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:51:33Z","timestamp":1757998293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483506002739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0014483506002739"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2006.05.019","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2006.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}