{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T12:00:01Z","timestamp":1778328001315,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.exer.2006.06.004","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T10:29:07Z","timestamp":1153304947000},"page":"1171-1178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["OPA1 expression in the human retina and optic nerve"],"prefix":"10.1016","volume":"83","author":[{"given":"An-Guor","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Ji","family":"Fann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May-Yung","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2006.06.004_bib1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1167\/iovs.03-1093","article-title":"Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer","volume":"45","author":"Aijaz","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.06.004_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/humu.9152","article-title":"Fourteen novel OPA1 mutations in autosomal dominant optic atrophy including two de novo mutations in sporadic optic atrophy","volume":"21","author":"Baris","year":"2003","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.exer.2006.06.004_bib4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jmg.32.12.951","article-title":"No evidence of genetic heterogeneity in dominant optic atrophy","volume":"32","author":"Bonneau","year":"1995","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s00439-001-0633-y","article-title":"Mutation spectrum and splicing variants in the OPA1 gene","volume":"109","author":"Delettre","year":"2001","journal-title":"Hum. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/mgme.2001.3278","article-title":"OPA1 (Kjer type) dominant optic atrophy: a novel mitochondrial disease","volume":"75","author":"Delettre","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.exer.2006.06.004_bib8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/hmg\/3.6.977","article-title":"Dominant optic atrophy (OPA1) mapped to chromosome 3q region. I. Linkage analysis","volume":"3","author":"Eiberg","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000310202","article-title":"Rod thresholds in dominantly inherited juvenile optic atrophy","volume":"202","author":"Elenius","year":"1991","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2006.06.004_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00401-005-0002-3","article-title":"Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration","volume":"111","author":"Frank","year":"2006","journal-title":"Acta. Neuropathol. (Berl.)"},{"key":"10.1016\/j.exer.2006.06.004_bib11","doi-asserted-by":"crossref","first-page":"18792","DOI":"10.1074\/jbc.M400920200","article-title":"Loss of the intermembrane space protein Mgm1\/OPA1 induces swelling and localized constrictions along the lengths of mitochondria","volume":"279","author":"Griparic","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.06.004_bib12","doi-asserted-by":"crossref","first-page":"27781","DOI":"10.1074\/jbc.M211311200","article-title":"Processing of Mgm1 by the Thomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA","volume":"278","author":"Herlan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.06.004_bib13","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/0002-9394(79)90565-8","article-title":"A clinicopathologic study of autosomal dominant optic atrophy","volume":"88","author":"Johnston","year":"1979","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2006.06.004_bib14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0161-6420(99)90013-1","article-title":"Dominant optic atrophy. Refining the clinical diagnostic criteria in light of genetic linkage studies","volume":"106","author":"Johnston","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2006.06.004_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s004390050323","article-title":"Refinement of the dominant optic atrophy locus (OPA1) to a 1.4-cM interval on chromosome 3q28-3q29, within a 3-Mb YAC contig","volume":"99","author":"Jonasdottir","year":"1997","journal-title":"Hum. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20586","article-title":"OPA1 expression in the normal rat retina and optic nerve","volume":"488","author":"Ju","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2006.06.004_bib17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1755-3768.1983.tb01424.x","article-title":"Histopathology of the eye, optic nerve and brain in a case of dominant optic atrophy","volume":"61","author":"Kjer","year":"1983","journal-title":"Acta. Ophthalmol."},{"key":"10.1016\/j.exer.2006.06.004_bib18","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1001\/archopht.1979.01020020248013","article-title":"Dominant optic atrophy. The clinical profile","volume":"97","author":"Kline","year":"1979","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2006.06.004_bib19","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1091\/mbc.e04-04-0294","article-title":"Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis","volume":"15","author":"Lee","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.exer.2006.06.004_bib20","first-page":"968","article-title":"Refinement of the OPA1 gene locus on chromosome 3q28-q29 to a region of 2-8 cM, in one Cuban pedigree with autosomal dominant optic atrophy type Kjer","volume":"57","author":"Lunkes","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature01633","article-title":"Mitochondrial membrane remodeling regulated by a conserved rhomboid protease","volume":"423","author":"McQuibban","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.exer.2006.06.004_bib22","doi-asserted-by":"crossref","first-page":"15834","DOI":"10.1074\/jbc.M109260200","article-title":"Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology","volume":"277","author":"Misaka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.06.004_bib23","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1074\/jbc.C200677200","article-title":"Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis","volume":"278","author":"Olichon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.06.004_bib24","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/hmg\/10.13.1359","article-title":"OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance","volume":"10","author":"Pesch","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib25","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1167\/iovs.03-1261","article-title":"OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina","volume":"45","author":"Pesch","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.06.004_bib26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0420.2005.00448.x","article-title":"Dominant optic atrophy: correlation between clinical and molecular genetic studies","volume":"83","author":"Puomila","year":"2005","journal-title":"Acta. Ophthalmol. Scand."},{"key":"10.1016\/j.exer.2006.06.004_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00006324-197203000-00001","article-title":"Diagnostic criteria in dominantly inherited juvenile optic atrophy. A report of three new families","volume":"49","author":"Smith","year":"1972","journal-title":"Am. J. Optom. Physiol. Optics."},{"key":"10.1016\/j.exer.2006.06.004_bib28","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/hmg\/10.13.1369","article-title":"Spectrum, frequency and penetrance of OPA1 mutations in dominant optic atrophy","volume":"10","author":"Toomes","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/jmg.34.2.117","article-title":"Genetic refinement of dominant optic atrophy (OPA1) locus to within a 2 cM interval of chromosome 3q","volume":"34","author":"Votruba","year":"1997","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.exer.2006.06.004_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archopht.116.3.351","article-title":"Clinical features in affected individuals from 21 pedigrees with dominant optic atrophy","volume":"116","author":"Votruba","year":"1998","journal-title":"Arch. Ophthalmol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:53:30Z","timestamp":1757998410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483506002934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0014483506002934"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2006.06.004","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OPA1 expression in the human retina and optic nerve","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2006.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}