{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:26Z","timestamp":1791246146361,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.exer.2006.06.010","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:06:30Z","timestamp":1156525590000},"page":"1303-1306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Wolfram syndrome 1 (WFS1) protein expression in retinal ganglion cells and optic nerve glia of the cynomolgus monkey"],"prefix":"10.1016","volume":"83","author":[{"given":"Hideo","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duco I.","family":"Hamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Kreczmanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Parel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainald","family":"Schmidt-Kastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2006.06.010_bib1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/eye.1997.226","article-title":"Optic atrophy in Wolfram (DIDMOAD) syndrome","volume":"11","author":"Barrett","year":"1997","journal-title":"Eye"},{"key":"10.1016\/j.exer.2006.06.010_bib2","first-page":"855","article-title":"Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity","volume":"59","author":"Collier","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib4","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/hmg\/ddg214","article-title":"Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product","volume":"12","author":"Hofmann","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/2441","article-title":"A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)","volume":"20","author":"Inoue","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib6","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/hmg\/ddh125","article-title":"Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion","volume":"13","author":"Ishihara","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/jmg.39.3.162","article-title":"Leber hereditary optic neuropathy","volume":"39","author":"Man","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2006.06.010_bib9","doi-asserted-by":"crossref","first-page":"52755","DOI":"10.1074\/jbc.M310331200","article-title":"Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium","volume":"278","author":"Osman","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.06.010_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004647-199901000-00001","article-title":"Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury?","volume":"19","author":"Paschen","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.exer.2006.06.010_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0994-95","article-title":"Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4","volume":"8","author":"Polymeropoulos","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.20175","article-title":"SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I","volume":"56","author":"Qi","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exer.2006.06.010_bib13","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1093\/hmg\/7.13.2021","article-title":"Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein","volume":"7","author":"Strom","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/hmg\/10.5.477","article-title":"WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain","volume":"10","author":"Takeda","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2006.06.010_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/eje.1.01945","article-title":"Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation","volume":"153","author":"Ueda","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.exer.2006.06.010_bib16","first-page":"715","article-title":"Diabetes mellitus and simple optic atrophy among siblings: report of four cases","volume":"13","author":"Wolfram","year":"1938","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.exer.2006.06.010_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbrc.2004.10.017","article-title":"Endoplasmic reticulum stress and N-glycosylation modulate expression of WFS1 protein","volume":"325","author":"Yamaguchi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506002983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:53:57Z","timestamp":1757998437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483506002983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0014483506002983"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2006.06.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wolfram syndrome 1 (WFS1) protein expression in retinal ganglion cells and optic nerve glia of the cynomolgus monkey","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2006.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}