{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:13:57Z","timestamp":1791209637691,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.exer.2006.10.011","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T07:12:16Z","timestamp":1164957136000},"page":"361-372","source":"Crossref","is-referenced-by-count":23,"title":["Fate of hypertonicity-stressed corneal epithelial cells depends on differential MAPK activation and p38MAPK\/Na\u2013K\u20132Cl cotransporter1 interaction"],"prefix":"10.1016","volume":"84","author":[{"given":"Jos\u00e9 E.","family":"Cap\u00f3-Aponte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor N.","family":"Bildin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn S.","family":"Pokorny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Reinach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2006.10.011_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/mrd.1080350105","article-title":"Effect of sodium and betaine in culture media on development and relative rates of protein synthesis in preimplantation mouse embryos in vitro","volume":"35","author":"Anbari","year":"1993","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.exer.2006.10.011_bib2","first-page":"2665","article-title":"Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector","volume":"34","author":"Araki","year":"1993","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.10.011_bib3","first-page":"614","article-title":"An SV40-immortalized human corneal epithelial cell line and its characterization","volume":"36","author":"Araki-Sasaki","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2006.10.011_bib4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bcp.2005.01.010","article-title":"Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium","volume":"69","author":"Balcerczyk","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2006.10.011_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-002-2002-8","article-title":"Hypertonicity-induced p38MAPK activation elicits recovery of corneal epithelial cell volume and layer integrity","volume":"193","author":"Bildin","year":"2003","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.exer.2006.10.011_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s002320001098","article-title":"Adaptation by corneal epithelial cells to chronic hypertonic stress depends on upregulation of Na:K:2Cl cotransporter gene and protein expression and ion transport activity","volume":"177","author":"Bildin","year":"2000","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.exer.2006.10.011_bib7","doi-asserted-by":"crossref","first-page":"C950","DOI":"10.1152\/ajpcell.1996.271.3.C950","article-title":"Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes","volume":"271","author":"Bortner","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib8","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0006-2952(98)00225-1","article-title":"A necessary role for cell shrinkage in apoptosis","volume":"56","author":"Bortner","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2006.10.011_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0962-8924(00)88932-1","article-title":"The role of DNA fragmentation in apoptosis","volume":"5","author":"Bortner","year":"1995","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.exer.2006.10.011_bib10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1095-6433(02)00203-9","article-title":"Response of renal inner medullary epithelial cells to osmotic stress","volume":"133","author":"Burg","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib11","doi-asserted-by":"crossref","first-page":"23961","DOI":"10.1074\/jbc.M312974200","article-title":"High osmolarity glycerol (HOG) pathway-induced phosphorylation and activation of 6-phosphofructo-2-kinase are essential for glycerol accumulation and yeast cell proliferation under hyperosmotic stress","volume":"279","author":"Dihazi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.10.011_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1095-6433(01)00439-1","article-title":"Cell cycle delay and apoptosis in response to osmotic stress","volume":"130","author":"Dmitrieva","year":"2001","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib13","doi-asserted-by":"crossref","unstructured":"Du, J.W., Zhang, F., Cap\u00f3-Aponte, Tachado, S.D., Zhang, J., Yu, F.X., Sack, R.A., Koziel, H., Reinach, P.S., 2006. AsialoGM1-mediated IL-8 release by human corneal epithelial cells requires co-expression of TLR5. Investig. Ophthalmol. Vis. Sci. 47, 4810\u20134818.","DOI":"10.1167\/iovs.06-0250"},{"key":"10.1016\/j.exer.2006.10.011_bib14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1113\/jphysiol.2005.087130","article-title":"Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts","volume":"567","author":"Friis","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1749-6632.1985.tb14862.x","article-title":"Na++K++2Cl\u2212 cotransport in animal cells\u2014its role in volume regulation","volume":"456","author":"Geck","year":"1985","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.exer.2006.10.011_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0074-7696(08)62498-5","article-title":"Membrane mechanisms and intracellular signalling in cell volume regulation","volume":"161","author":"Hoffmann","year":"1995","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.exer.2006.10.011_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.1989.69.2.315","article-title":"Membrane mechanisms in volume and pH regulation in vertebrate cells","volume":"69","author":"Hoffmann","year":"1989","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2006.10.011_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02260106","article-title":"Na+, K+, Cl\u2212 cotransport and its regulation in Ehrlich ascites tumor cells. Ca2+\/calmodulin and protein kinase C dependent pathways","volume":"131","author":"Jensen","year":"1993","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.exer.2006.10.011_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1385\/JMN:21:2:111","article-title":"Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling","volume":"21","author":"Junger","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.exer.2006.10.011_bib20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1076\/ceyr.23.6.397.6965","article-title":"Control of SV-40 transformed RCE cell proliferation by growth-factor-induced cell cycle progression","volume":"23","author":"Kang","year":"2001","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2006.10.011_bib21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.exer.2006.10.011_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jcb.240580206","article-title":"Cell cycle and apoptosis: common pathways to life and death","volume":"58","author":"King","year":"1995","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exer.2006.10.011_bib23","doi-asserted-by":"crossref","first-page":"C425","DOI":"10.1152\/ajpcell.1999.277.3.C425","article-title":"JNK is a volume-sensitive kinase that phosphorylates the Na\u2013K\u20132Cl cotransporter in vitro","volume":"277","author":"Klein","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib24","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00352.2001","article-title":"Phosphorylation of the salivary Na(+)\u2013K(+)\u20132Cl(\u2013) cotransporter","volume":"282","author":"Kurihara","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib25","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/bies.950180708","article-title":"Protein kinase cascades activated by stress and inflammatory cytokines","volume":"18","author":"Kyriakis","year":"1996","journal-title":"Bioessays"},{"key":"10.1016\/j.exer.2006.10.011_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/physrev.1998.78.1.247","article-title":"Functional significance of cell volume regulatory mechanisms","volume":"78","author":"Lang","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2006.10.011_bib27","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s00424-001-0768-7","article-title":"Stimulation of TNF alpha expression by hyperosmotic stress","volume":"443","author":"Lang","year":"2002","journal-title":"Pflueg. Arch."},{"key":"10.1016\/j.exer.2006.10.011_bib28","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1074\/jbc.M412393200","article-title":"HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis","volume":"280","author":"Lee","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2006.10.011_bib29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.exer.2005.08.019","article-title":"JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells","volume":"82","author":"Li","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2006.10.011_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-4889(01)00189-6","article-title":"Activation of NKCC1 by hyperosmotic stress in human tracheal epithelial cells involves PKC-delta and ERK","volume":"1589","author":"Liedtke","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2006.10.011_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/153537020222600711","article-title":"Corneal epithelial wound healing","volume":"226","author":"Lu","year":"2001","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.exer.2006.10.011_bib32","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.140216197","article-title":"Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis","volume":"97","author":"Maeno","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2006.10.011_bib33","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.STR.29.12.2631","article-title":"Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells","volume":"29","author":"Malek","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.exer.2006.10.011_bib34","doi-asserted-by":"crossref","first-page":"F981","DOI":"10.1152\/ajprenal.00301.2001","article-title":"Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells","volume":"282","author":"Michea","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib35","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1152\/ajprenal.2000.278.2.F209","article-title":"Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells","volume":"278","author":"Michea","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib36","first-page":"867","article-title":"The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells","volume":"60","author":"Moran","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2006.10.011_bib37","doi-asserted-by":"crossref","first-page":"C1513","DOI":"10.1152\/ajpcell.1995.269.6.C1513","article-title":"Endothelial Na\u2013K\u2013Cl cotransport regulation by tonicity and hormones: phosphorylation of cotransport protein","volume":"269","author":"O'Donnell","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7793.2001.0003g.x","article-title":"Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)","volume":"532","author":"Okada","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1083\/jcb.114.2.337","article-title":"Stimulation of bumetanide-sensitive Na+\/K+\/Cl\u2212 cotransport by different mitogens in synchronized human skin fibroblasts is essential for cell proliferation","volume":"114","author":"Panet","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2006.10.011_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/(SICI)1097-4652(200001)182:1<109::AID-JCP12>3.0.CO;2-A","article-title":"Overexpression of the Na(+)\/K(+)\/Cl(\u2013) cotransporter gene induces cell proliferation and phenotypic transformation in mouse fibroblasts","volume":"182","author":"Panet","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jcp.1041580115","article-title":"Bumetanide and furosemide inhibited vascular endothelial cell proliferation","volume":"158","author":"Panet","year":"1994","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2006.10.011_bib42","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1053\/jhep.2002.35447","article-title":"Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis","volume":"36","author":"Reinehr","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.exer.2006.10.011_bib43","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1126\/science.274.5290.1194","article-title":"Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors","volume":"274","author":"Rosette","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.exer.2006.10.011_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physrev.2000.80.1.211","article-title":"Sodium\u2013potassium\u2013chloride cotransport","volume":"80","author":"Russell","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2006.10.011_bib45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0003-9861(02)00047-4","article-title":"Expression and regulation of the Na(+)\/K(+)\/2Cl(\u2013) cotransporter NKCC1 in rat liver and human HuH-7 hepatoma cells","volume":"401","author":"Schliess","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.exer.2006.10.011_bib46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/advan.00034.2004","article-title":"Cellular volume homeostasis","volume":"28","author":"Strange","year":"2004","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.exer.2006.10.011_bib47","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1523-1755.2001.060002553.x","article-title":"Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells","volume":"60","author":"Terada","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.exer.2006.10.011_bib48","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506004180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483506004180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T13:27:59Z","timestamp":1555939679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483506004180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0014483506004180"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2006.10.011","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}