{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:29:20Z","timestamp":1762147760714,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.exer.2008.03.009","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T07:32:47Z","timestamp":1205739167000},"page":"929-935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice"],"prefix":"10.1016","volume":"86","author":[{"given":"Nobuyoshi","family":"Kitaichi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadamichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Yoshihisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Ohgami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Norisugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nishihira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho-ichi","family":"Yamagishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2008.03.009_bib1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/ki.1997.172","article-title":"Transcriptional activation of\u00a0a\u00a0hybrid promoter composed of cytomegalovirus enhancer and beta-actin\/beta-globin gene in glomerular epithelial cells in vivo","volume":"51","author":"Akagi","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.exer.2008.03.009_bib2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.exer.2005.09.012","article-title":"Corneal NF-kappaB activity is necessary for the retention of transparency in the cornea of UV-B-exposed transgenic reporter mice","volume":"82","author":"Alexander","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2008.03.009_bib3","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2005-05-2011","article-title":"Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB","volume":"107","author":"Amin","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.exer.2008.03.009_bib4","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(88)90143-2","article-title":"The jun proto-oncogene is positively autoregulated by its product, Jun\/AP-1","volume":"55","author":"Angel","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.exer.2008.03.009_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1755-3768.1987.tb08506.x","article-title":"The efficacy of a UV-blocking soft contact lens in protecting cornea against UV radiation","volume":"65","author":"Bergmanson","year":"1987","journal-title":"Acta Ophthalmol. (Copenh.)"},{"key":"10.1016\/j.exer.2008.03.009_bib6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.153.3731.80","article-title":"Mechanism of a reaction in vitro associated with delayed-type hypersensitivity","volume":"153","author":"Bloom","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.exer.2008.03.009_bib7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"Calandra","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2008.03.009_bib8","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.179.6.1895","article-title":"The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor","volume":"179","author":"Calandra","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2008.03.009_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1475-1313.1990.tb00879.x","article-title":"Ocular hazards arising from depletion of the natural atmospheric ozone layer: a review","volume":"10","author":"Charman","year":"1990","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2008.03.009_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00006324-198407000-00009","article-title":"Ultraviolet-B damages corneal endothelium","volume":"61","author":"Cullen","year":"1984","journal-title":"Am. J. Optom. Physiol. Opt."},{"key":"10.1016\/j.exer.2008.03.009_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1073\/pnas.56.1.72","article-title":"Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction","volume":"56","author":"David","year":"1966","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exer.2008.03.009_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0002-9440(10)62992-6","article-title":"Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation","volume":"167","author":"Di Girolamo","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2008.03.009_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1751-1097.1989.tb04095.x","article-title":"Long-term effects of a single dose of ultraviolet-B on albino rabbit cornea\u2014I. in vivo analyses","volume":"49","author":"Doughty","year":"1989","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.exer.2008.03.009_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1751-1097.1990.tb01735.x","article-title":"Long-term effects of a single dose of ultraviolet-B on albino rabbit cornea\u2014II. Deturgescence and fluid pump assessed in vitro","volume":"51","author":"Doughty","year":"1990","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.exer.2008.03.009_bib15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1365-2567.2000.00011.x","article-title":"Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia","volume":"100","author":"Honma","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.exer.2008.03.009_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/labinvest.3700491","article-title":"Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors","volume":"87","author":"Kabashima","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2008.03.009_bib17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","article-title":"AP-1 function and regulation","volume":"9","author":"Karin","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.exer.2008.03.009_bib18","first-page":"2483","article-title":"Ultraviolet irradiation induces the production of multiple cytokines by human corneal cells","volume":"38","author":"Kennedy","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.03.009_bib19","first-page":"247","article-title":"Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis","volume":"40","author":"Kitaichi","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.03.009_bib20","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/bjo.84.12.1423","article-title":"Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis","volume":"84","author":"Kitaichi","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2008.03.009_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1076\/0271-3683(200002)2021-DFT109","article-title":"Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies","volume":"20","author":"Kitaichi","year":"2000","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2008.03.009_bib22","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00417-005-0168-3","article-title":"Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitis","volume":"244","author":"Kitaichi","year":"2006","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2008.03.009_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35041591","article-title":"Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1","volume":"408","author":"Kleemann","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.exer.2008.03.009_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00004397-200201000-00014","article-title":"Macrophage migration inhibitory factor in uveitis","volume":"42","author":"Kotake","year":"2002","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.exer.2008.03.009_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.33549\/physiolres.930272","article-title":"UV-B induced production of MMP-2 and MMP-9 in human corneal cells","volume":"52","author":"Kozak","year":"2003","journal-title":"Physiol. Res."},{"key":"10.1016\/j.exer.2008.03.009_bib26","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1167\/iovs.03-0591","article-title":"UV-induced signaling pathways associated with corneal epithelial cell apoptosis","volume":"44","author":"Lu","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.03.009_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound healing\u2014aiming for perfect skin regeneration","volume":"276","author":"Martin","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exer.2008.03.009_bib28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0014-5793(96)00386-9","article-title":"Identification and immunohistochemical localization of macrophage migration inhibitory factor in human cornea","volume":"385","author":"Matsuda","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2008.03.009_bib29","first-page":"1555","article-title":"Expression of macrophage migration inhibitory factor in corneal wound healing in rats","volume":"38","author":"Matsuda","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.03.009_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-5728(97)00061-1","article-title":"Expression of\u00a0macrophage migration inhibitory factor in rat retina and its immunohistochemical localization","volume":"77","author":"Matsuda","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.exer.2008.03.009_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1755-3768.1987.tb08504.x","article-title":"Ultrastructural analysis of corneal exposure to UV radiation","volume":"65","author":"Pitts","year":"1987","journal-title":"Acta Ophthalmol. (Copenh.)"},{"key":"10.1016\/j.exer.2008.03.009_bib32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1600-0420.2004.00369.x","article-title":"Protective role of corneal epithelium against ultraviolet radiation damage","volume":"82","author":"Podskochy","year":"2004","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.exer.2008.03.009_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00003226-200001000-00019","article-title":"Apoptosis in UV-exposed rabbit corneas","volume":"19","author":"Podskochy","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2008.03.009_bib34","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/02713688709034873","article-title":"The effects of UV-B irradiation on the corneal endothelium","volume":"6","author":"Riley","year":"1987","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2008.03.009_bib35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1755-3768.1985.tb05253.x","article-title":"Changes in the rabbit corneal stroma caused by UV-radiation","volume":"63","author":"Ringvold","year":"1985","journal-title":"Acta Ophthalmol. (Copenh.)"},{"key":"10.1016\/j.exer.2008.03.009_bib36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1755-3768.1982.tb05780.x","article-title":"Changes of the cornea endothelium after ultraviolet radiation","volume":"60","author":"Ringvold","year":"1982","journal-title":"Acta Ophthalmol. (Copenh.)"},{"key":"10.1016\/j.exer.2008.03.009_bib37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1523-1755.2004.00394.x","article-title":"Transgene of MIF induces podocyte injury and progressive mesangial sclerosis in the mouse kidney","volume":"65","author":"Sasaki","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.exer.2008.03.009_bib38","first-page":"579","article-title":"Phototoxicity and the cornea","volume":"84","author":"Schein","year":"1992","journal-title":"J. Natl. Med. Assoc."},{"key":"10.1016\/j.exer.2008.03.009_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-5793(96)00120-2","article-title":"Identification of macrophage migration inhibitory factor (MIF) in human skin and its immunohistochemical localization","volume":"381","author":"Shimizu","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2008.03.009_bib40","doi-asserted-by":"crossref","first-page":"13729","DOI":"10.1074\/jbc.M400150200","article-title":"Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells","volume":"279","author":"Shimizu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.03.009_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1442-9071.2001.00405.x","article-title":"Expression of macrophage migration inhibitory factor during Pseudomonas keratitis","volume":"29","author":"Thakur","year":"2001","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2008.03.009_bib42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0925-4439(01)00105-3","article-title":"Erk 1\/2 differentially regulates the expression from the 1G\/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells","volume":"1586","author":"Tower","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2008.03.009_bib43","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1038\/sj.onc.1208547","article-title":"Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells","volume":"24","author":"Wang","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.exer.2008.03.009_bib44","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1074\/jbc.M303650200","article-title":"Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts","volume":"279","author":"Watanabe","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.03.009_bib45","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1073\/pnas.90.4.1272","article-title":"A\u00a0macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens","volume":"90","author":"Wistow","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exer.2008.03.009_bib46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cyto.2006.09.006","article-title":"Macrophage migration inhibitory factor in zinc-allergic systemic contact dermatitis","volume":"35","author":"Yanagi","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.exer.2008.03.009_bib47","first-page":"3665","article-title":"IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva","volume":"41","author":"Yoshida","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.03.009_bib48","first-page":"1631","article-title":"Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection","volume":"43","author":"Yoshida","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.03.009_bib49","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1242\/dev.113.4.1293","article-title":"Developmental analysis of the eye lens obsolescence (Elo) gene in the mouse: cell proliferation and Elo gene expression in the aggregation chimera","volume":"113","author":"Yoshiki","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.exer.2008.03.009_bib50","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0002-9440(10)61238-2","article-title":"Tissue regeneration using macrophage migration inhibitory factor-impregnated gelatin microbeads in cutaneous wounds","volume":"167","author":"Zhao","year":"2005","journal-title":"Am. J. Pathol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483508000961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483508000961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:25:27Z","timestamp":1762147527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483508000961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0014483508000961"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2008.03.009","relation":{},"ISSN":["0014-4835"],"issn-type":[{"type":"print","value":"0014-4835"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage migration inhibitory factor ameliorates UV-induced photokeratitis in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2008.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}