{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:48:22Z","timestamp":1787161702410,"version":"build-2736575974"},"reference-count":75,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.exer.2008.09.002","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T04:45:17Z","timestamp":1221799517000},"page":"848-858","source":"Crossref","is-referenced-by-count":53,"title":["Lacritin and other new proteins of the lacrimal functional unit"],"prefix":"10.1016","volume":"88","author":[{"given":"Robert L.","family":"McKown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W.","family":"Raab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Karnati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon W.","family":"Laurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2008.09.002_bib1","first-page":"75","article-title":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop","volume":"2","author":"Lemp","year":"2007","journal-title":"Ocul Surf"},{"key":"10.1016\/j.exer.2008.09.002_bib2","first-page":"5230","article-title":"Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells","volume":"63","author":"Bachelder","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2008.09.002_bib3","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1167\/iovs.03-0589","article-title":"Murine ocular heparanase expression before and during infection with Pseudomonas aeruginosa","volume":"45","author":"Berk","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib4","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1074\/jbc.M708525200","article-title":"Two heparanase splicing variants with distinct properties are necessary in early Xenopus development","volume":"283","author":"Bertolesi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.devcel.2007.03.020","article-title":"The two TORCs and Akt","volume":"12","author":"Bhaskar","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.exer.2008.09.002_bib6","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1167\/iovs.07-0430","article-title":"Functions of MUC16 in corneal epithelial cells","volume":"48","author":"Blalock","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib7","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelial","volume":"49","author":"Blalock","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib8","doi-asserted-by":"crossref","first-page":"32384","DOI":"10.1074\/jbc.M704089200","article-title":"Mapping the binding site on small ankyrin 1 for obscurin","volume":"282","author":"Borzok","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12035-007-0034-x","article-title":"Alsin and the molecular pathways of amyotrophic lateral sclerosis","volume":"36","author":"Chandran","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2008.09.002_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.138.3.495","article-title":"Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network","volume":"138","author":"Chen","year":"1997","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib11","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1172\/JCI27331.","article-title":"Calcineurin\/Nfat signaling is required for perinatal lung maturation and function","volume":"116","author":"Dav\u00e9","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.exer.2008.09.002_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1086\/383285","article-title":"Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)","volume":"74","author":"Donaudy","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2008.09.002_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0854.2007.00677.x","article-title":"Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells","volume":"9","author":"Fader","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.exer.2008.09.002_bib14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0076-6879(90)82035-Z","article-title":"One-dimensional gel electrophoresis","volume":"182","author":"Garfin","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.exer.2008.09.002_bib15","doi-asserted-by":"crossref","first-page":"33064","DOI":"10.1074\/jbc.M702685200","article-title":"Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4\/B subfamily members","volume":"282","author":"Gu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib16","article-title":"Proteomic analyses in contact lens-related dry eye","volume":"48","author":"Green-Church","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib17","first-page":"291","article-title":"Mass spectrometry-based proteomic analyses of contact lens deposition","volume":"14","author":"Green-Church","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2008.09.002_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1091\/mbc.E07-05-0430","article-title":"Cholecystokinin activates pancreatic calcineurin\u2013NFAT signaling in vitro and in vivo","volume":"19","author":"Gurda","year":"2008","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.exer.2008.09.002_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.febslet.2004.07.092","article-title":"ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics","volume":"575","author":"Hadano","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2008.09.002_bib20","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M709154200","article-title":"Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides","author":"Hawrani","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng2058","article-title":"A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21","volume":"39","author":"van Heel","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2008.09.002_bib22","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s004170100301","article-title":"Alterations in expression of mucin, tenascin-c and syndecan-1 in the conjunctiva following retinal surgery and plaque radiotherapy","volume":"239","author":"Heimann","year":"2001","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2008.09.002_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature05097","article-title":"Calcineurin\/NFAT signalling regulates pancreatic beta-cell growth and function","volume":"443","author":"Heit","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exer.2008.09.002_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2007.11.047","article-title":"NFATc1 balances quiescence and proliferation of skin stem cells","volume":"132","author":"Horsley","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exer.2008.09.002_bib25","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1210\/me.2005-0097","article-title":"hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI\/SNF-like BAF complexes","volume":"9","author":"Huang","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.exer.2008.09.002_bib26","doi-asserted-by":"crossref","first-page":"27534","DOI":"10.1074\/jbc.M403012200","article-title":"Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells","volume":"279","author":"Hughes","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib27","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1110\/ps.40101","article-title":"Aberrant mobility phenomena of the DNA repair protein XPA","volume":"10","author":"Iakoucheva","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib28","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0161-6420(80)35143-9","article-title":"Basic tear flow. Does it exist?","volume":"87","author":"Jordan","year":"1980","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2008.09.002_bib30","unstructured":"Kitagawa, K., Tomosugi, N., Tuchida, H., Sasaki, H., 2007. Automated identification and quantification of tear proteins in Sj\u00f6gren's syndrome by LC\u2013MS on a hybrid linear ion trap mass spectrometer. In: Fifth International Conference on the Tear Film and Ocular Surface: Basic Science and Clinical Relevance, Taormina, Sicily, Italy."},{"key":"10.1016\/j.exer.2008.09.002_bib31","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1021\/pr0498133","article-title":"Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis","volume":"4","author":"Koo","year":"2005","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2008.09.002_bib32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/OPX.0b013e318181ae73","article-title":"Dry eye and designer ophthalmics","volume":"85","author":"Laurie","year":"2008","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib33","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1167\/iovs.04-0816","article-title":"Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva","volume":"45","author":"Levin","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/humu.20138","article-title":"Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease","volume":"25","author":"Li","year":"2005","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.exer.2008.09.002_bib35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/icb.2008.6","article-title":"Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity","volume":"86","author":"Lonyai","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.200511134","article-title":"Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin","volume":"74","author":"Ma","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.exer.2007.01.025","article-title":"Focus on molecules: lacritin","volume":"86","author":"Ma","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2008.09.002_bib38","first-page":"1000","article-title":"Prediction and biochemical characterization of intrinsic disorder in the structure of proteolysis-inducing factor\/dermcidin","volume":"6","author":"Majczak","year":"2007","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.exer.2008.09.002_bib39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1086\/504927","article-title":"ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia","volume":"79","author":"Mannan","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2008.09.002_bib40","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1002\/art.23073","volume":"56","author":"Manoussakis","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exer.2008.09.002_bib41","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ajhg.2008.01.010","article-title":"Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene","volume":"82","author":"Merner","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2008.09.002_bib42","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/labinvest.3700230","article-title":"Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS\/CREB3L1 fusion gene","volume":"85","author":"Mertens","year":"2005","journal-title":"Lab. Investig."},{"key":"10.1016\/j.exer.2008.09.002_bib43","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/108076803322279390","article-title":"P2Y(2) receptor elicits PAS- positive glycoprotein secretion from rabbit conjunctival goblet cells in vivo","volume":"9","author":"Murakami","year":"2003","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2008.09.002_bib44","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.exer.2007.07.019","article-title":"Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes","volume":"85","author":"Nakajima","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2008.09.002_bib45","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1007\/s00018-008-7584-6","article-title":"Heparanase involvement in physiology and disease","volume":"65","author":"Nasser","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib46","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1167\/iovs.04-1380","article-title":"The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts","volume":"46","author":"Ozyildirim","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib47","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1242\/dev.011171","article-title":"Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex\u00a0vivo\u00a0submandibular gland branching morphogenesis","volume":"134","author":"Patel","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.exer.2008.09.002_bib48","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.0801027105","article-title":"Molecular recognition of parathyroid hormone by its G protein-coupled receptor","volume":"105","author":"Pioszak","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2008.09.002_bib49","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1073\/pnas.1932980100","article-title":"A neural survival factor is a candidate oncogene in breast cancer","volume":"100","author":"Porter","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2008.09.002_bib50","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1016\/j.febslet.2007.06.040","article-title":"Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy","volume":"581","author":"Proikas-Cezanne","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2008.09.002_bib51","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/pr050492k","article-title":"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry","volume":"5","author":"Ramachandran","year":"2006","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2008.09.002_bib52","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/S0039-6257(00)00203-4","article-title":"The ocular surface and tear film and their dysfunction in dry eye disease","volume":"45","author":"Rolando","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2008.09.002_bib53","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1074\/jbc.M708740200","article-title":"Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain","volume":"283","author":"Runge","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jmbi.2001.4748","article-title":"cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland","volume":"310","author":"Sanghi","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib29","unstructured":"Samudre, S.S., Schneider, J.L., Loose-Thurman, P., Sheppard, J.D., Laurie, G.W., McKown, R.L., Williams, P.B. Lacritin, a novel tear glycoprotein, stimulates tear production in rabbits without ocular toxicity. submitted for publication."},{"key":"10.1016\/j.exer.2008.09.002_bib55","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.286.17.2114","article-title":"Hormone replacement therapy and dry eye syndrome","volume":"286","author":"Schaumberg","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.exer.2008.09.002_bib56","doi-asserted-by":"crossref","first-page":"23804","DOI":"10.1074\/jbc.M602762200","article-title":"Characterization of mechanisms involved in secretion of active heparanase","volume":"281","author":"Shafat","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2008.09.002_bib57","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1134027","article-title":"Protrudin induces neurite formation by directional membrane trafficking","volume":"314","author":"Shirane","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.exer.2008.09.002_bib58","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/bioinformatics\/bth013","article-title":"Visualization of near-optimal sequence alignments","volume":"20","author":"Smoot","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2008.09.002_bib59","doi-asserted-by":"crossref","first-page":"R72","DOI":"10.1186\/gb-2006-7-8-r72","article-title":"Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors","volume":"7","author":"de Souza","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib60","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2008.09.002_bib61","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ng1980","article-title":"Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum","volume":"39","author":"Stevanin","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2008.09.002_bib62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1542-0124(12)70147-7","article-title":"Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous- deficient dry eye","volume":"2","author":"Sullivan","year":"2004","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2008.09.002_bib63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1167\/iovs.07-1038","article-title":"Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells","volume":"49","author":"Sumiyoshi","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2008.09.002_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbrc.2006.12.229","article-title":"ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics","volume":"354","author":"Suzuki-Utsunomiya","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2008.09.002_bib65","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/ncb1416","article-title":"Plexin-A1 and its interaction with\u00a0DAP12 in immune responses and bone homeostasis","volume":"8","author":"Takegahara","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib66","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/01.ico.0000133993.14768.a9","article-title":"Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye","volume":"23","author":"Tauber","year":"2004","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2008.09.002_bib67","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1021\/pr0497576","article-title":"Diagnostic potential of tear proteomic patterns in Sj\u00f6gren's syndrome","volume":"4","author":"Tomosugi","year":"2005","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2008.09.002_bib68","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/bjo.2005.080846","article-title":"Proteomic analysis of human meibomian gland secretions","volume":"90","author":"Tsai","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2008.09.002_bib69","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1006\/exer.2002.2054","article-title":"Down-regulation of androgen receptor expression and inhibition of lacrimal gland cell proliferation by retinoic acid","volume":"75","author":"Ubels","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2008.09.002_bib70","first-page":"39","article-title":"Progressive external ophthalmoplegia and multiple mitochondrial DNA deletions","volume":"102","author":"Van Goethem","year":"2002","journal-title":"Acta Neurol. Belg"},{"key":"10.1016\/j.exer.2008.09.002_bib71","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.200605140","article-title":"Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways","volume":"174","author":"Wang","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2008.09.002_bib72","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1006\/exer.1999.0742","article-title":"Stimulation with carbachol alters endomembrane distribution and plasma membrane expression of intracellular proteins in lacrimal acinar cells","volume":"69","author":"Yang","year":"1999","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2008.09.002_bib73","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0002-9440(10)62321-8","article-title":"Heparanase regulates murine hair growth","volume":"166","author":"Zcharia","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2008.09.002_bib74","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1086\/522037","article-title":"Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases","volume":"81","author":"Zhernakova","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2008.09.002_bib75","doi-asserted-by":"crossref","first-page":"400","DOI":"10.47102\/annals-acadmedsg.V35N6p400","article-title":"Characterisation of human tear proteins using high-resolution mass spectrometry","volume":"35","author":"Zhou","year":"2006","journal-title":"Ann. Acad. Med. Singap."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483508003175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483508003175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T20:39:37Z","timestamp":1684528777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483508003175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0014483508003175"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2008.09.002","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}