{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:05:04Z","timestamp":1773281104213,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.exer.2009.05.002","type":"journal-article","created":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T08:25:38Z","timestamp":1242289538000},"page":"608-617","source":"Crossref","is-referenced-by-count":24,"title":["Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models"],"prefix":"10.1016","volume":"89","author":[{"given":"Ganesh","family":"Prasanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Fortner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathie","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Carreiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soisurin","family":"Sartnurak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hovhannes","family":"Gukasyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Niesman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajiv","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Rui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lafontaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau Doan","family":"Almaden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2009.05.002_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.plefa.2004.03.021","article-title":"Prostaglandin e2 receptor subtypes, ep1, ep2, ep3 and ep4 in human and mouse ocular tissues\u2013a comparative immunohistochemical study","volume":"71","author":"Biswas","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.exer.2009.05.002_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1146\/annurev.pharmtox.41.1.661","article-title":"Prostanoid receptors: subtypes and signaling","volume":"41","author":"Breyer","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.exer.2009.05.002_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/108076801750125658","article-title":"Functional pharmacological evidence for ep2 and ep4 prostanoid receptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells","volume":"17","author":"Crider","year":"2001","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2009.05.002_bib6","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1074\/jbc.M109440200","article-title":"Phosphorylation of glycogen synthase kinase-3 and stimulation of t-cell factor signaling following activation of ep2 and ep4 prostanoid receptors by prostaglandin e2","volume":"277","author":"Fujino","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2009.05.002_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/mol.105.011833","article-title":"Differential regulation of phosphorylation of the camp response element-binding protein after activation of ep2 and ep4 prostanoid receptors by prostaglandin e2","volume":"68","author":"Fujino","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2009.05.002_bib7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/HYPERTENSIONAHA.107.088948","article-title":"Prostaglandin e2 induces vascular relaxation by e-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase","volume":"50","author":"Hristovska","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.exer.2009.05.002_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1359\/jbmr.051110","article-title":"A nonprostanoid ep4 receptor selective prostaglandin e2 agonist restores bone mass and strength in aged, ovariectomized rats","volume":"21","author":"Ke","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exer.2009.05.002_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1158\/0008-5472.CAN-06-2559","article-title":"Transcriptional cooperation between the transforming growth factor-beta and wnt pathways in mammary and intestinal tumorigenesis","volume":"67","author":"Labbe","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2009.05.002_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bone.2007.06.013","article-title":"Prostaglandin e2 ep4 agonist (ono-4819) accelerates bmp-induced osteoblastic differentiation","volume":"41","author":"Nakagawa","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.exer.2009.05.002_bib11","first-page":"1774","article-title":"Alterations of ocular nitric oxide synthase in human glaucoma","volume":"36","author":"Nathanson","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2009.05.002_bib12","first-page":"1765","article-title":"Identification of an extensive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye","volume":"36","author":"Nathanson","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2009.05.002_bib13","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1167\/iovs.05-1627","article-title":"The prostanoid ep2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey","volume":"47","author":"Nilsson","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2009.05.002_bib14","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0026-895X(25)09407-6","article-title":"Two gs-coupled prostaglandin e\u00a0receptor subtypes, ep2 and ep4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist","volume":"50","author":"Nishigaki","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2009.05.002_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.lfs.2003.09.031","article-title":"Ep2 and ep4 prostanoid receptor signaling","volume":"74","author":"Regan","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.exer.2009.05.002_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/01.shk.0000129338.99410.5d","article-title":"A prostaglandin e2 receptor subtype ep4 agonist attenuates cardiovascular depression in endotoxin shock by inhibiting inflammatory cytokines and nitric oxide production","volume":"22","author":"Sakamoto","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.exer.2009.05.002_bib17","first-page":"1475","article-title":"Expression and localization of fp and ep prostanoid receptor subtypes in human ocular tissues","volume":"43","author":"Schlotzer-Schrehardt","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2009.05.002_bib18","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin e receptors","volume":"282","author":"Sugimoto","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.exer.2009.05.002_bib19","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0039-6257(97)80010-0","article-title":"Effects of exogenous prostaglandins on aqueous humor dynamics and blood\u2013aqueous barrier function","volume":"41","author":"Toris","year":"1997","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2009.05.002_bib20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/exer.1994.1158","article-title":"Aqueous humor in glaucomatous eyes contains an increased level of tgf-beta 2","volume":"59","author":"Tripathi","year":"1994","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2009.05.002_bib21","first-page":"1056","article-title":"Increased expression of the wnt antagonist sfrp-1 in glaucoma elevates intraocular pressure","volume":"118","author":"Wang","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2009.05.002_bib22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/jop.1995.11.447","article-title":"Molecular characterization and ocular hypotensive properties of the prostanoid ep2 receptor","volume":"11","author":"Woodward","year":"1995","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2009.05.002_bib23","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.08-3031","article-title":"Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow","author":"Woodward","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2009.05.002_bib24","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1167\/iovs.06-0296","article-title":"Effects of tgf-beta2, bmp-4, and gremlin in the trabecular meshwork: implications for glaucoma","volume":"48","author":"Wordinger","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483509001341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483509001341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T11:47:11Z","timestamp":1739101631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483509001341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0014483509001341"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2009.05.002","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}