{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:28:21Z","timestamp":1778250501942,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007745","name":"Massachusetts Lions Eye Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.exer.2010.04.008","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T08:30:03Z","timestamp":1272443403000},"page":"153-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Visual cycle modulation in neurovascular retinopathy"],"prefix":"10.1016","volume":"91","author":[{"given":"James D.","family":"Akula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radouil","family":"Tzekov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara L.","family":"Favazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya C.","family":"Vyhovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan Y.","family":"Benador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Mocko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McGee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Fulton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2010.04.008_bib1","article-title":"The anatomy of the rat eye with oxygen-induced retinopathy","author":"Akula","year":"2009","journal-title":"Doc. Ophthalmol"},{"key":"10.1016\/j.exer.2010.04.008_bib2","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1167\/iovs.07-0204","article-title":"Rod photoreceptor function predicts blood vessel abnormality in retinopathy of prematurity","volume":"48","author":"Akula","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib3","first-page":"2499","article-title":"The neurovascular relation in oxygen-induced retinopathy","volume":"14","author":"Akula","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2010.04.008_bib4","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/0042-6989(87)90155-6","article-title":"\u201cSelf-screening\u201d of rhodopsin in rod outer segments","volume":"27","author":"Alpern","year":"1987","journal-title":"Vision Res."},{"key":"10.1016\/j.exer.2010.04.008_bib5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/bjo.85.3.366","article-title":"The absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment","volume":"85","author":"Arden","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib6","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/bjo.2004.062547","article-title":"Spare the rod and spoil the eye","volume":"89","author":"Arden","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib7","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0042-6989(98)00004-2","article-title":"Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis","volume":"38","author":"Arden","year":"1998","journal-title":"Vision Res."},{"key":"10.1016\/j.exer.2010.04.008_bib8","article-title":"The development of the rat model of retinopathy of prematurity","author":"Barnett","year":"2009","journal-title":"Doc. Ophthalmol"},{"key":"10.1016\/j.exer.2010.04.008_bib9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1113\/jphysiol.1979.sp012716","article-title":"Responses of retinal rods to single photons","volume":"288","author":"Baylor","year":"1979","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2010.04.008_bib10","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1167\/iovs.08-2958","article-title":"Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo","volume":"50","author":"Berkowitz","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib11","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1167\/iovs.06-1516","article-title":"High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity","volume":"48","author":"Berkowitz","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib12","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/BF00203324","article-title":"Intraretinal oxygen tension in the rat eye","volume":"229","author":"Cringle","year":"1991","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib13","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1167\/iovs.06-0646","article-title":"Rod photoreceptor loss in Rho\u2212\/\u2212 mice reduces retinal hypoxia and hypoxia-regulated gene expression","volume":"47","author":"de Gooyer","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib14","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1167\/iovs.06-0647","article-title":"Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration","volume":"47","author":"de Gooyer","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib15","first-page":"2481","article-title":"Evidence for a brief period of enhanced oxygen susceptibility in the rat model of oxygen-induced retinopathy","volume":"43","author":"Dembinska","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/jn.1961.24.4.427","article-title":"Dark and light adaptation in pigmented and white rat as measured by electroretinogram threshold","volume":"24","author":"Dodt","year":"1961","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exer.2010.04.008_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1167\/iovs.07-0916","article-title":"Early manifestations of postnatal hyperoxia on the retinal structure and function of the neonatal rat","volume":"49","author":"Dorfman","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib18","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","article-title":"Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial","volume":"121","author":"ETROP","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10633-008-9127-8","article-title":"Retinal degenerative and hypoxic ischemic disease","volume":"118","author":"Fulton","year":"2009","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib20","first-page":"647","article-title":"The relation of retinal sensitivity and rhodopsin in developing rat retina","volume":"25","author":"Fulton","year":"1984","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3109\/02713689109020334","article-title":"The quantity of rhodopsin in young human eyes","volume":"10","author":"Fulton","year":"1991","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2010.04.008_bib22","first-page":"1878","article-title":"The rhodopsin content of human eyes","volume":"40","author":"Fulton","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01203688","article-title":"Electroretinogram responses and refractive errors in patients with a history of retinopathy prematurity","volume":"91","author":"Fulton","year":"1995","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib24","first-page":"1038","article-title":"The development of the rod photoresponse from dark-adapted rats","volume":"36","author":"Fulton","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2009.06.003","article-title":"The neurovascular retina in retinopathy of prematurity","author":"Fulton","year":"2009","journal-title":"Prog. Retin Eye Res"},{"key":"10.1016\/j.exer.2010.04.008_bib26","first-page":"S820","article-title":"Persistent dysfunction in a rat model of ROP","volume":"39","author":"Fulton","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib27","first-page":"168","article-title":"Rod photoreceptors in infant rats with a history of oxygen exposure","volume":"40","author":"Fulton","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib28","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1167\/iovs.05-0646","article-title":"Diagnosis of plus disease in retinopathy of prematurity using retinal image multiscale analysis","volume":"46","author":"Gelman","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib29","doi-asserted-by":"crossref","first-page":"8162","DOI":"10.1073\/pnas.0503318102","article-title":"Positively charged retinoids are potent and selective inhibitors of the trans\u2013cis isomerization in the retinoid (visual) cycle","volume":"102","author":"Golczak","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2010.04.008_bib30","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial","volume":"102","author":"Good","year":"2004","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.exer.2010.04.008_bib31","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1073\/pnas.86.4.1224","article-title":"Transduction heats in retinal rods: tests of the role of cGMP by pyroelectric calorimetry","volume":"86","author":"Hagins","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2010.04.008_bib32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.visres.2007.07.009","article-title":"Retinal degeneration in children: dark adapted visual threshold and arteriolar diameter","volume":"48","author":"Hansen","year":"2008","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2010.04.008_bib33","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1167\/iovs.08-1780","article-title":"Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease","volume":"49","author":"Hartnett","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S0952523800009275","article-title":"A computational model of the amplitude and implicit time of the b-wave of the human ERG","volume":"8","author":"Hood","year":"1992","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2010.04.008_bib35","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/emboj\/21.7.1545","article-title":"GCAP1 rescues rod photoreceptor response in GCAP1\/GCAP2 knockout mice","volume":"21","author":"Howes","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2010.04.008_bib36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0042-6989(79)90143-3","article-title":"A schematic eye for the rat","volume":"19","author":"Hughes","year":"1979","journal-title":"Vision Res."},{"key":"10.1016\/j.exer.2010.04.008_bib37","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/S0042-6989(03)00482-6","article-title":"Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization","volume":"43","author":"Kuksa","year":"2003","journal-title":"Vision Res."},{"key":"10.1016\/j.exer.2010.04.008_bib38","doi-asserted-by":"crossref","first-page":"10368","DOI":"10.1073\/pnas.181329198","article-title":"An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration","volume":"98","author":"Lahdenranta","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2010.04.008_bib39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1113\/jphysiol.1992.sp019111","article-title":"A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors","volume":"449","author":"Lamb","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2010.04.008_bib40","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1167\/iovs.06-0016","article-title":"The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurity","volume":"47","author":"Liu","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib41","first-page":"532","article-title":"Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California)","volume":"12","author":"Lutty","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2010.04.008_bib69","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1523\/JNEUROSCI.16-02-00563.1996","article-title":"Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings","volume":"16","author":"Lyubarsky","year":"1996","journal-title":"J. Neurosci"},{"key":"10.1016\/j.exer.2010.04.008_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1085\/jgp.107.1.19","article-title":"The kinetics of inactivation of the rod phototransduction cascade with constant Cai2+","volume":"107","author":"Lyubarsky","year":"1996","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.exer.2010.04.008_bib44","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1109\/TBME.2002.800789","article-title":"Retinal vascular tree morphology: a semi-automatic quantification","volume":"49","author":"Martinez-Perez","year":"2002","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.exer.2010.04.008_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.media.2006.11.004","article-title":"Segmentation of blood vessels from red-free and fluorescein retinal images","volume":"11","author":"Martinez-Perez","year":"2007","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.exer.2010.04.008_bib46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1113\/jphysiol.2003.050724","article-title":"The effect of light on outer segment calcium in salamander rods","volume":"552","author":"Matthews","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2010.04.008_bib47","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1350-9462(01)00002-7","article-title":"Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina","volume":"20","author":"McBee","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2010.04.008_bib48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10633-009-9209-2","article-title":"Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats","volume":"120","author":"Messias","year":"2010","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib49","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1073\/pnas.0503460102","article-title":"RPE65 is the isomerohydrolase in the retinoid visual cycle","volume":"102","author":"Moiseyev","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2010.04.008_bib50","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0161-6420(91)32074-8","article-title":"Incidence and early course of retinopathy of prematurity. The cryotherapy for retinopathy of prematurity cooperative group","volume":"98","author":"Palmer","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2010.04.008_bib51","first-page":"638","article-title":"Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases","volume":"72","author":"Pe\u2019er","year":"1995","journal-title":"Lab Invest."},{"key":"10.1016\/j.exer.2010.04.008_bib52","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1203\/00006450-199412000-00007","article-title":"Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat","volume":"36","author":"Penn","year":"1994","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.exer.2010.04.008_bib53","first-page":"2063","article-title":"The range of PaO2 variation determines the severity of oxygen-induced retinopathy in newborn rats","volume":"36","author":"Penn","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib54","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1113\/jphysiol.1978.sp012297","article-title":"Kinetics of bleaching and regeneration of rhodopsin in abnormal (RCS) and normal albino rats in vivo","volume":"278","author":"Perlman","year":"1978","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2010.04.008_bib55","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1006\/exer.1997.0365","article-title":"Development of the human retinal vasculature: cellular relations and VEGF expression","volume":"65","author":"Provis","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2010.04.008_bib56","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0005-2728(93)90038-H","article-title":"Amplification and kinetics of the activation steps in phototransduction","volume":"1141","author":"Pugh","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2010.04.008_bib57","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1021\/cr960141c","article-title":"The biochemistry of the visual cycle","volume":"101","author":"Rando","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.exer.2010.04.008_bib58","first-page":"221","article-title":"The effect of light history on the aspartate-isolated fast-PIII responses of the albino rat retina","volume":"37","author":"Reiser","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib59","first-page":"3169","article-title":"Extraretinal neovascularization induced by hypoxic episodes in the neonatal rat","volume":"35","author":"Reynaud","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib60","first-page":"2071","article-title":"Effect of prior oxygen exposure on the electroretinographic responses of infant rats","volume":"36","author":"Reynaud","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib61","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/359843a0","article-title":"Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis","volume":"359","author":"Shweiki","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.exer.2010.04.008_bib70","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1073\/pnas.98.4.1835","article-title":"Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy","volume":"94","author":"Sieving","year":"2001","journal-title":"PNAS USA"},{"key":"10.1016\/j.exer.2010.04.008_bib62","first-page":"1888","article-title":"Monitoring communications between photoreceptors and pigment epithelial cells: effects of \u201cmild\u201d systemic hypoxia","volume":"28","author":"Steinberg","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2010.04.008_bib63","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pharmtox.47.120505.105225","article-title":"Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents","volume":"47","author":"Travis","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.exer.2010.04.008_bib64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10633-009-9191-8","article-title":"Dimethyl sulphoxide dose\u2013response on rat retinal function","volume":"119","author":"Tsai","year":"2009","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2010.04.008_bib65","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0952523805224112","article-title":"Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia","volume":"22","author":"Wellard","year":"2005","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2010.04.008_bib66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/00031305.1986.10475378","article-title":"Prediction limits for a univariate normal observation","volume":"40","author":"Whitmore","year":"1986","journal-title":"Am. Stat."},{"key":"10.1016\/j.exer.2010.04.008_bib67","series-title":"Color Science: Concepts and Methods, Quantitative Data and Formulae","author":"Wyszecki","year":"1982"},{"key":"10.1016\/j.exer.2010.04.008_bib68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.33.1.61","article-title":"The renewal of photoreceptor cell outer segments","volume":"33","author":"Young","year":"1967","journal-title":"J. Cell Biol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483510001193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483510001193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:27:05Z","timestamp":1762147625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483510001193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0014483510001193"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2010.04.008","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visual cycle modulation in neurovascular retinopathy","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2010.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}